Optimal Path to Epigenetic Switching

We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.

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Bibliographische Detailangaben
Hauptverfasser:	Roma, David Marin, O'Flanagan, Ruadhan A, Ruckenstein, Andrei E, Sengupta, Anirvan M, Mukhopadhyay, Ranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Quantitative Biology - Cell Behavior Quantitative Biology - Molecular Networks
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Beschreibung
Zusammenfassung:	We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.
DOI:	10.48550/arxiv.q-bio/0406008