Influence of supercoiling on the disruption of dsDNA

We propose that supercoiling energizes double-stranded DNA (dsDNA) so as to facilitate thermal fluctuations to an unzipped state. We support this with a model of two elastic rods coupled via forces that represent base pair interactions. Supercoiling is shown to lead to a spatially localized higher e...

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Hauptverfasser: Chitanvis, Shirish M, Welch, Paul M
Format: Artikel
Sprache:eng
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