The i-TED Compton Camera Array for real-time boron imaging and determination during treatments in Boron Neutron Capture Therapy
This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for...
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| creator | Torres-Sánchez, Pablo Lerendegui-Marco, Jorge Balibrea-Correa, Javier Babiano-Suárez, Victor Gameiro, Bernardo Ladarescu, Ion Álvarez-Rodríguez, Patricia Daugas, Jean-Michel Koester, Ulli Michelagnoli, Caterina Pedrosa-Rivera, Maria Porras, Ignacio Ruiz-Magaña, Maria José Ruiz-Ruiz, Carmen Domingo-Pardo, César |
| description | This paper explores the adaptation and application of i-TED Compton imagers
for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED
array, previously utilized in nuclear astrophysics experiments at CERN, is
being optimized for detecting and imaging 478 keV gamma-rays, critical for
accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize
the i-TED detector configuration and enhance its performance in the challenging
radiation environment typical of BNCT. Additionally, advanced 3D image
reconstruction algorithms, including a combination of back-projection and
List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are
implemented and validated through simulations. Preliminary experimental tests
at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a
clinical setting, with ongoing experiments focusing on improving imaging
capabilities in realistic BNCT conditions. |
| doi_str_mv | 10.48550/arxiv.2409.10107 |
| format | Article |
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for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED
array, previously utilized in nuclear astrophysics experiments at CERN, is
being optimized for detecting and imaging 478 keV gamma-rays, critical for
accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize
the i-TED detector configuration and enhance its performance in the challenging
radiation environment typical of BNCT. Additionally, advanced 3D image
reconstruction algorithms, including a combination of back-projection and
List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are
implemented and validated through simulations. Preliminary experimental tests
at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a
clinical setting, with ongoing experiments focusing on improving imaging
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for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED
array, previously utilized in nuclear astrophysics experiments at CERN, is
being optimized for detecting and imaging 478 keV gamma-rays, critical for
accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize
the i-TED detector configuration and enhance its performance in the challenging
radiation environment typical of BNCT. Additionally, advanced 3D image
reconstruction algorithms, including a combination of back-projection and
List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are
implemented and validated through simulations. Preliminary experimental tests
at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a
clinical setting, with ongoing experiments focusing on improving imaging
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for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED
array, previously utilized in nuclear astrophysics experiments at CERN, is
being optimized for detecting and imaging 478 keV gamma-rays, critical for
accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize
the i-TED detector configuration and enhance its performance in the challenging
radiation environment typical of BNCT. Additionally, advanced 3D image
reconstruction algorithms, including a combination of back-projection and
List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are
implemented and validated through simulations. Preliminary experimental tests
at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a
clinical setting, with ongoing experiments focusing on improving imaging
capabilities in realistic BNCT conditions.</abstract><doi>10.48550/arxiv.2409.10107</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Physics - Medical Physics |
| title | The i-TED Compton Camera Array for real-time boron imaging and determination during treatments in Boron Neutron Capture Therapy |
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