Design and analysis of a microplate assay in the presence of multiple restrictions on the randomization

Experiments using multi-step protocols often involve several restrictions on the randomization. For a specific application to in vitro testing on microplates, a design was required with both a split-plot and a strip-plot structure. On top of two-level treatment factors and the factors that define th...

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Veröffentlicht in:arXiv.org 2023-03
Hauptverfasser: Bohyn, Alexandre, Schoen, Eric D, Ng, Chee Ping, Bishard, Kristina, Haarmans, Manon, Trietsch, Sebastian J, Goos, Peter
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Sprache:eng
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Zusammenfassung:Experiments using multi-step protocols often involve several restrictions on the randomization. For a specific application to in vitro testing on microplates, a design was required with both a split-plot and a strip-plot structure. On top of two-level treatment factors and the factors that define the randomization restrictions, a multi-level fixed blocking factor not involving further restrictions on the randomization had to be added. We develop a step-by-step approach to construct a design for the microplate experiment and analyze a response. To consolidate the approach, we study various alternative scenarios for the experiment.
ISSN:2331-8422
DOI:10.48550/arxiv.2303.05817