EmbryosFormer: Deformable Transformer and Collaborative Encoding-Decoding for Embryos Stage Development Classification

The timing of cell divisions in early embryos during the In-Vitro Fertilization (IVF) process is a key predictor of embryo viability. However, observing cell divisions in Time-Lapse Monitoring (TLM) is a time-consuming process and highly depends on experts. In this paper, we propose EmbryosFormer, a...

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Hauptverfasser: Nguyen, Tien-Phat, Pham, Trong-Thang, Nguyen, Tri, Le, Hieu, Nguyen, Dung, Lam, Hau, Nguyen, Phong, Fowler, Jennifer, Tran, Minh-Triet, Le, Ngan
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Sprache:eng
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Zusammenfassung:The timing of cell divisions in early embryos during the In-Vitro Fertilization (IVF) process is a key predictor of embryo viability. However, observing cell divisions in Time-Lapse Monitoring (TLM) is a time-consuming process and highly depends on experts. In this paper, we propose EmbryosFormer, a computational model to automatically detect and classify cell divisions from original time-lapse images. Our proposed network is designed as an encoder-decoder deformable transformer with collaborative heads. The transformer contracting path predicts per-image labels and is optimized by a classification head. The transformer expanding path models the temporal coherency between embryo images to ensure monotonic non-decreasing constraint and is optimized by a segmentation head. Both contracting and expanding paths are synergetically learned by a collaboration head. We have benchmarked our proposed EmbryosFormer on two datasets: a public dataset with mouse embryos with 8-cell stage and an in-house dataset with human embryos with 4-cell stage. Source code: https://github.com/UARK-AICV/Embryos.
DOI:10.48550/arxiv.2210.04615