Twisted S-Duality

S-duality is a nontrivial self-duality of type IIB string theory that exchanges strong and weak coupling. We give a mathematically rigorous description of how S-duality acts on a low-energy supersymmetry-protected sector of IIB string theory, using a conjectural description of such protected sectors in terms of topological string theory. We then give some applications which are of relevance to Geometric Langlands Theory and the representation theory of the Yangian.