A fluid bilayer phase in aqueous mixtures of fatty alcohol and cationic surfactant

The \(L_\alpha\) phase of lipid bilayers is a fluid self-assembled state, key to the formulation of cosmetics, detergents and pharmaceutics. Despite having been extensively scrutinized in self-assembled phospholipid or surfactant bilayers, the formation of a fluid \(L_\alpha\) state has defied understanding in mixtures of fatty alcohols, surfactants and water, where is viewed as the essential step for the preparation of creamy dispersions. Here, atomistic molecular dynamics simulations show the existence of a fluid bilayer in aqueous mixtures of cetyl (C\(_{16}\)OH) and stearyl (C\(_{18}\)OH) alcohols, and cetyl-trimethylammonium chloride (CTAC). These simulated bilayer systems display not only a rich temperature phase diagram with many of the features seen in experiments but carry also the unambigous signature of fluid bilayer behavior.