Vascular networks due to dynamically arrested crystalline ordering of elongated cells

Recent experimental and theoretical studies suggest that crystallization and glass-like solidification are useful analogies for understanding cell ordering in confluent biological tissues. It remains unexplored how cellular ordering contributes to pattern formation during morphogenesis. With a compu...

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Veröffentlicht in:arXiv.org 2013-06
Hauptverfasser: Palm, Margriet M, Merks, Roeland M H
Format: Artikel
Sprache:eng
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Zusammenfassung:Recent experimental and theoretical studies suggest that crystallization and glass-like solidification are useful analogies for understanding cell ordering in confluent biological tissues. It remains unexplored how cellular ordering contributes to pattern formation during morphogenesis. With a computational model we show that a system of elongated, cohering biological cells can get dynamically arrested in a network pattern. Our model provides a new explanation for the formation of cellular networks in culture systems that exclude intercellular interaction via chemotaxis or mechanical traction.
ISSN:2331-8422
DOI:10.48550/arxiv.1210.7164