Following the Birth, Life, and Death of mRNAs in Single Cells

Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how...

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Veröffentlicht in:Annual review of cell and developmental biology 2023-10, Vol.39 (1), p.253-275
Hauptverfasser: Eichenberger, Bastian T, Griesbach, Esther, Mitchell, Jessica, Chao, Jeffrey A
Format: Artikel
Sprache:eng
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Zusammenfassung:Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how regulation is coupled between steps in the mRNA life cycle. Additionally, these methodologies are now being applied in multicellular systems and animals to provide more nuanced insights into the physiological regulation of RNA metabolism.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-022723-024045