Bullous Pemphigoid and Disseminated Mycobacterium abscessus Infection in a Patient with Anti-IFN-γ Autoantibody: The First Case Report

Disseminated non-tuberculosis mycobacteria (dNTM) infection is an uncommon but critical infectious disease. This infection occurs almost exclusively in immunocompromised patients, and treating such an infection is a challenge for clinical physicians. Recently, adult-onset immunodeficiency with anti-IFN-γ autoantibody has been recognized as an immunodeficiency disease, particularly in the Asian population, and patients with anti-IFN-γ autoantibody became more susceptible to dNTM infection. Notably, the skin reaction may be the primary or secondary manifestation in patients with dNTM infection and anti-IFN-γ autoantibody. Here, we report a 67-year-old woman without systemic diseases presented to our hospital with bullous pemphigoid and disseminated Mycobacterium abscessus infection and anti-IFN-γ autoantibody was identified in further immune test.