Tc-99m ECD Brain Perfusion SPECT in the Logopenic Variant of Primary Progressive Aphasia

We report the case of a 75-year-old woman who presented with gradually progressive speech disorders and memory impairment. Brain magnetic resonance imaging revealed no significant finding. Technetium-99m ethyl cysteinate dimer brain perfusion single photon emission computed tomography (SPECT) with semiquantitative analysis revealed hypoperfusion in the left hemisphere, predominant on the posterior temporal lobe extending to the posterior parietal lobe. After considering the clinical presentation and SPECT findings, we established a diagnosis of logopenic variant of primary progressive aphasia.