An Improved Process for the Synthesis of 5-Bromo-3-(1-methylpiperidin-4-yl)-1H-indole: A Key Intermediate in the Synthesis of Naratriptan Hydrochloride

An improved process has been developed for the synthesis of 5-bromo-3-(1-methylpiperidin-4-yl)-1H-indole, a key intermediate of naratriptan hydrochloride, which is used as a drug for migraine. A novel one-pot synthetic procedure using triethyl silane was developed for scale-up.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic process research & development 2010-07, Vol.14 (4), p.918-920
Hauptverfasser:	Shashikumar, Nellisara D, Krishnamurthy, Ganga Naika, Rao K, Sundara Raj, Shridhara, Kanakamajalu, Naik, Halehatti S. Bhojya, Nagarajan, Kuppuswamy
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	An improved process has been developed for the synthesis of 5-bromo-3-(1-methylpiperidin-4-yl)-1H-indole, a key intermediate of naratriptan hydrochloride, which is used as a drug for migraine. A novel one-pot synthetic procedure using triethyl silane was developed for scale-up.
ISSN:	1083-6160 1520-586X
DOI:	10.1021/op100018r