Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)

Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)

This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity pr...

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Veröffentlicht in:Organic process research & development 2002-05, Vol.6 (3), p.273-278
Hauptverfasser: Chou, Shan-Yen, Yin, Wei-Kung, Chung, Yuh-Shan, Chang, Lien-Shange, Liu, Chin-Wei, Chen, Shyh-Fong, Shih, Kae-Shyang
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container_end_page 278
container_issue 3
container_start_page 273
container_title Organic process research & development
container_volume 6
creator Chou, Shan-Yen
Yin, Wei-Kung
Chung, Yuh-Shan
Chang, Lien-Shange
Liu, Chin-Wei
Chen, Shyh-Fong
Shih, Kae-Shyang
description This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.
doi_str_mv 10.1021/op0100807
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title Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)
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