Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)

Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)

This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic process research & development 2002-05, Vol.6 (3), p.273-278
Hauptverfasser: Chou, Shan-Yen, Yin, Wei-Kung, Chung, Yuh-Shan, Chang, Lien-Shange, Liu, Chin-Wei, Chen, Shyh-Fong, Shih, Kae-Shyang
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.
ISSN:1083-6160
1520-586X
DOI:10.1021/op0100807