Amide-Directed Alkenylation of sp2 C−H Bonds Catalyzed by a Cationic Rh(I)/BIPHEP Complex Under Mild Conditions: Dramatic Rate Acceleration by a 1-Pyrrolidinecarbonyl Group

Amide-Directed Alkenylation of sp2 C−H Bonds Catalyzed by a Cationic Rh(I)/BIPHEP Complex Under Mild Conditions: Dramatic Rate Acceleration by a 1-Pyrrolidinecarbonyl Group

A cationic rhodium(I)/BIPHEP complex catalyzes amide-directed regioselective alkenylations of olefinic or aromatic sp2 C−H bonds in good yields under mild reaction conditions. The use of a 1-pyrrolidinecarbonyl group as a directing group dramatically accelerates the reaction.

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Veröffentlicht in:Organic letters 2009-02, Vol.11 (3), p.689-692
Hauptverfasser: Shibata, Yu, Otake, Yousuke, Hirano, Masao, Tanaka, Ken
Format: Artikel
Sprache:eng
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Zusammenfassung:A cationic rhodium(I)/BIPHEP complex catalyzes amide-directed regioselective alkenylations of olefinic or aromatic sp2 C−H bonds in good yields under mild reaction conditions. The use of a 1-pyrrolidinecarbonyl group as a directing group dramatically accelerates the reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802767s