Cu2+-Responsive Bimodal (Optical/MRI) Contrast Agent for Cellular Imaging

Cu2+-Responsive Bimodal (Optical/MRI) Contrast Agent for Cellular Imaging

A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free...

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Veröffentlicht in:Organic letters 2013-09, Vol.15 (18), p.4702-4705
Hauptverfasser: Jang, Joo Hee, Bhuniya, Sankarprasad, Kang, Jongeun, Yeom, Areum, Hong, Kwan Soo, Kim, Jong Seung
Format: Artikel
Sprache:eng
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Zusammenfassung:A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4025293