Pyridine Ligands as Promoters in PdII/0-Catalyzed C–H Olefination Reactions

Pyridine Ligands as Promoters in PdII/0-Catalyzed C–H Olefination Reactions

Commercially available pyridine ligands can significantly enhance the rate, yield, substrate scope, and site selectivity of arene C–H olefination (Fujiwara–Moritani) reactions. The use of a 1:1 ratio of Pd/pyridine proved critical to maximize reaction rates and yields.

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Veröffentlicht in:Organic letters 2012-04, Vol.14 (7), p.1760-1763
Hauptverfasser: Kubota, Asako, Emmert, Marion H, Sanford, Melanie S
Format: Artikel
Sprache:eng ; jpn
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Zusammenfassung:Commercially available pyridine ligands can significantly enhance the rate, yield, substrate scope, and site selectivity of arene C–H olefination (Fujiwara–Moritani) reactions. The use of a 1:1 ratio of Pd/pyridine proved critical to maximize reaction rates and yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol300281p