Toward the Total Synthesis of Disorazole A1 and C1:  Asymmetric Synthesis of a Masked Southern Segment

Toward the Total Synthesis of Disorazole A1 and C1:  Asymmetric Synthesis of a Masked Southern Segment

A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A1 involves a Sonogashira coupling between a C1‘−C10‘ enyne and a suitably protected C11‘−C19‘ vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.

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Veröffentlicht in:Organic letters 2002-09, Vol.4 (19), p.3239-3242
Hauptverfasser: Hartung, Ingo V, Niess, Barbara, Haustedt, Lars Ole, Hoffmann, H. Martin R
Format: Artikel
Sprache:eng
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Zusammenfassung:A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A1 involves a Sonogashira coupling between a C1‘−C10‘ enyne and a suitably protected C11‘−C19‘ vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026468j