Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via 19F NMR Barcodes
Fluorinated boronic acid-appended benzyl bipyridinium salts, derived from 4,4′-, 3,4′-, and 3,3′-bipyridines, were synthesized and used to detect and differentiate diol-containing analytes at physiological conditions via 19F NMR spectroscopy. An array of three water-soluble boronic acid receptors in...
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Veröffentlicht in: | Journal of the American Chemical Society 2015-12, Vol.137 (49), p.15402-15405 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Fluorinated boronic acid-appended benzyl bipyridinium salts, derived from 4,4′-, 3,4′-, and 3,3′-bipyridines, were synthesized and used to detect and differentiate diol-containing analytes at physiological conditions via 19F NMR spectroscopy. An array of three water-soluble boronic acid receptors in combination with 19F NMR spectroscopy discriminates nine diol-containing bioanalytescatechol, dopamine, fructose, glucose, glucose-1-phosphate, glucose-6-phosphate, galactose, lactose, and sucroseat low mM concentrations. Characteristic 19F NMR fingerprints are interpreted as two-dimensional barcodes without the need of multivariate analysis techniques. |
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ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/jacs.5b10934 |