Strasseriolides A–D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251

A novel family of four potent antimalarial macrolides, strasseriolides A–D (1–4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their absolute configurations, were elucidated by HRMS, NMR...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2020-09, Vol.22 (17), p.6709-6713
Hauptverfasser: Annang, Frederick, Pérez-Moreno, Guiomar, González-Menéndez, Víctor, Lacret, Rodney, Pérez-Victoria, Ignacio, Martín, Jesús, Cantizani, Juan, de Pedro, Nuria, Choquesillo-Lazarte, Duane, Ruiz-Pérez, Luis M, González-Pacanowska, Dolores, Genilloud, Olga, Vicente, Francisca, Reyes, Fernando
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A novel family of four potent antimalarial macrolides, strasseriolides A–D (1–4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their absolute configurations, were elucidated by HRMS, NMR spectroscopy, and X-ray single-crystal diffraction. The four compounds gave respective IC50 values of 9.810, 0.013, 0.123, and 0.128 μM against Plasmodium falciparum 3D7 parasites with no significant cytotoxicity against the HepG2 cell line.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01665