Strasseriolides A–D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251
A novel family of four potent antimalarial macrolides, strasseriolides A–D (1–4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their absolute configurations, were elucidated by HRMS, NMR...
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Veröffentlicht in: | Organic letters 2020-09, Vol.22 (17), p.6709-6713 |
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Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A novel family of four potent antimalarial macrolides, strasseriolides A–D (1–4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their absolute configurations, were elucidated by HRMS, NMR spectroscopy, and X-ray single-crystal diffraction. The four compounds gave respective IC50 values of 9.810, 0.013, 0.123, and 0.128 μM against Plasmodium falciparum 3D7 parasites with no significant cytotoxicity against the HepG2 cell line. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.0c01665 |