Selective C–P(O) Bond Cleavage of Organophosphine Oxides by Sodium

Selective C–P(O) Bond Cleavage of Organophosphine Oxides by Sodium

Sodium exhibits better efficacy and selectivity than Li and K for converting Ph3P­(O) to Ph2P­(OM). The destiny of PhNa co-generated is disclosed. A series of alkyl halides R4X and aryl halides ArX all react with Ph2P­(ONa) to produce the corresponding phosphine oxides in good to excellent yields....

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Veröffentlicht in:Journal of organic chemistry 2020-11, Vol.85 (21), p.14166-14173
Hauptverfasser: Zhang, Jian-Qiu, Ikawa, Eiichi, Fujino, Hiroyoshi, Naganawa, Yuki, Nakajima, Yumiko, Han, Li-Biao
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:Sodium exhibits better efficacy and selectivity than Li and K for converting Ph3P­(O) to Ph2P­(OM). The destiny of PhNa co-generated is disclosed. A series of alkyl halides R4X and aryl halides ArX all react with Ph2P­(ONa) to produce the corresponding phosphine oxides in good to excellent yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c01642