Synthetic Approaches to New Drugs Approved during 2018

Synthetic Approaches to New Drugs Approved during 2018

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-s...

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Veröffentlicht in:Journal of medicinal chemistry 2020-10, Vol.63 (19), p.10652-10704
Hauptverfasser: Flick, Andrew C, Leverett, Carolyn A, Ding, Hong X, McInturff, Emma, Fink, Sarah J, Helal, Christopher J, DeForest, Jacob C, Morse, Peter D, Mahapatra, Subham, O’Donnell, Christopher J
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry, Medicinal
Drug Approval
Drug Discovery
History, 21st Century
Life Sciences & Biomedicine
Molecular Structure
Pharmaceutical Preparations - chemistry
Pharmacology & Pharmacy
Science & Technology
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Beschreibung
Zusammenfassung:New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 39 new chemical entities approved for the first time globally in 2018.
ISSN:0022-2623
1520-4804
DOI:10.1021/acs.jmedchem.0c00345