Rigor and reproducibility in genetics and genomics peer-reviewed, published, cited
Intro -- Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Cited -- Copyright -- Contents -- Contributors -- Preface -- Section 1: Introduction -- Chapter 1: Rigor and reproducibility in genetic research and the effects on scientific reporting and public discourse -- Intr...
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London ; San Diego, CA ; Cambridge, MA ; Oxford
Academic Press, an imprint of Elsevier
[2024]
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| Schriftenreihe: | Translational and applied genomics series
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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| Zusammenfassung: | Intro -- Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Cited -- Copyright -- Contents -- Contributors -- Preface -- Section 1: Introduction -- Chapter 1: Rigor and reproducibility in genetic research and the effects on scientific reporting and public discourse -- Introduction -- What is the rigor and reproducibility crisis? -- The issue of waning public trust in scientific research -- What are the contributing factors to the reproducibility crisis? -- The societal importance of open science -- Conclusions -- References -- Chapter 2: Unveiling the hidden curriculum: Developing rigor and reproducibility values through teaching and mentorship -- Introduction -- In the classroom -- In practice -- The stakes: Responsible research practices, ethics, and societal context -- The nature of science -- Science communication, publishing and peer review -- Quantitative reasoning and analysis -- Sloppy science and academic misconduct -- Experiential learning and CUREs -- In advising -- In the research lab -- In practice -- Habits of mind -- Protocols -- Communication of expectations -- Lab meetings and journal clubs -- Trainee engagement -- Accountability structures -- Conflicts of interest or commitment -- Feedback and reflection -- What to do if you are worried about integrity in your lab -- Mentoring for equity, diversity and inclusion (EDI) -- Support for mentorship in RCR practices -- Conclusion and future work -- References -- Section 2: Genotyping -- Chapter 3: Genome-wide association studies (GWAS): What are they, when to use them? -- Introduction and history -- Study design and statistical methods -- Frequentist vs Bayesian modeling -- GWAS for case and control association testing -- GWAS for quantitative traits -- Quality control for GWAS -- Technical QC -- Genetic QC -- Mendelian's law of segregation QC. |
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| Beschreibung: | xx, 482 Seiten Illustrationen, Diagramme |
| ISBN: | 9780128172186 |