Resolving the cholesterol controversy the scientists who proved the lipid hypothesis of causation of atherosclerosis and coronary heart disease
"This book recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built. The narrative covers a period of just under a hundred years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 191...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
London ; Hackensack, NJ
World Scientific Publishing Europe Ltd
[2023]
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| Schlagworte: | |
| Online-Zugang: | DE-578 |
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Inhaltsangabe:
- Introduction to the Lipid Hypothesis : the role of cholesterol in atherosclerosis
- Nikolai Anitschkow : The cholesterol-fed rabbit, an animal model of atherosclerosis
- John Gofman and Richard Havel : The discovery that cholesterol is transported by lipoproteins in the blood and their centrifugal analysis
- Thomas Dawber and William Kannel : The Framingham Study and risk factors for coronary heart disease
- Ancel Keys : The Seven Countries study and the role of dietary fat in determining cholesterol levels in populations
- Michael Oliver : Pros and cons of lowering cholesterol
- Donald Fredrickson and Robert Levy : The classification of disorders of lipoprotein metabolism
- John Yudkin : The role of sugar in coronary heart disease
- Sir John McMichael and J. R. Anthony Mitchell : Cardiological opponents of the lipid hypothesis
- Nicolas Myant : Familial Hypercholesterolaemia
- Joseph Goldstein and Michael Brown : Discovery of the LDL receptor
- Daniel Steinberg : The role of oxidised LDL in atherosclerosis
- Kåre Berg : Discovery of Lipoprotein (a)
- Gerd Utermann : Discovery of apoE isoforms and their role in lipid metabolism
- Akira Endo : The discovery of the first statin
- P. Roy Vagelos, Alfred Alberts and Jonathan Tobert : The development of statins for clinical use
- Terje Pedersen, James Shepherd and Sir Rory Collins : The statin trials that
- proved the lipid hypothesis
- Impact of proof of the lipid hypothesis on the science and practice of Medicine
- The future of clinical lipidology