Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response
The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase acti...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2021
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
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| Online-Zugang: | kostenfrei |
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