Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases
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| Format: | Buch |
| Sprache: | English |
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Cambridge, MA ; San Diego, CA ; Oxford, United Kingdom ; London, United Kingdom
Academic Press, an imprint of Elsevier
2021
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| Ausgabe: | First edition |
| Schriftenreihe: | Current topics in membranes
volume 87 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases |c edited by Yun Fang, Committee on Molecular Metabolism and Nutrition, Biological Sciences Division; Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, United States |
| 250 | |a First edition | ||
| 264 | 1 | |a Cambridge, MA ; San Diego, CA ; Oxford, United Kingdom ; London, United Kingdom |b Academic Press, an imprint of Elsevier |c 2021 | |
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Datensatz im Suchindex
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| adam_text | Contents Contributors ix Preface xiii 1. Multiscale geometry and mechanics of lipid monolayer collapse 1 Angelo Rosario Carotenuto, Nhung Nguyen, Kathleen Cao, Anna Gaffney, Alan J. Waring, Ka Yee C. Lee, David Owen, Massimiliano Fraldi, Luca Deseri, and Luka Pocivavsek 1. Introduction 2 2. Methods 6 3. Experimental results 13 4. Finite element analysis 23 5. Multiscale geometry of lipid monolayers 29 6. Conclusions 40 Acknowledgments 41 References 41 2. Cardiovascular mechanosensitive ion channels—Translating physical forces into physiological responses 47 İbra S. Fancher 1. Introduction to mechanosensitive (MS) channels in mammalian systems 48 2. Mechanosensitive channels Incardiovascular physiology—Overview 58 3. Mechanosensitive channels in the vasculature 58 4. Mechanosensitive channels in heart 73 5. Mechanosensitive channels In baroreceptors 79 6. Conclusions and perspectives 83 Acknowledgments 84 References 84 3. Atorvastatin and blood flow regulate expression of distinctive sets of genes in mouse carotid artery endothelium 97 Sandeep Kumar, Sanjoli Sur, Julian Perez, Catherine Demos, Dong-Won Kang, Chan Woo Kim, Sarah Hu, Ke Xu, Jing Yang, and Hanjoong Jo 1. Introduction 2. Materials and methods 99 101 v
Contents VI 3. Results 106 4. Discussion 122 Acknowledgments 126 Author contributions 126 Competing interests 126 References 126 4. Endothelial mechanotransduction in cardiovascular development and regeneration: emerging approaches and animal models 131 Susana Cavallero, Ana M. Blázquez-Medela, Sandro Satta, and Tzung K. Hsiai 1. Introduction 132 2. Zebrafish model of mechanotransduction 134 3. Mechanoreceptors in cardiac development 143 4. Conclusion 146 References 146 5. Enhancing mechanosensing: Enhancers and enhancer-derived long non-coding RNAs inendothelial response to flow 153 Zhen Bouman Chen, Xuejing Liu, and Aleysha T. Chen 1. Introduction 154 2. Flow-responsive EC enhancers 156 3. Enhancer IncRNAs (elncRNAs) as flow-responsive elements in ECs 158 4. Conclusion and perspective 161 Acknowledgment 163 References 163 6. SWI/SNF (BAF) complexes: From framework to a functional role in endothelial mechanotransduction 171 Sandeep Kumar 1. Introduction 172 2. Mechanotransduction and BAFcomplex 186 3. Future perspective 190 References 191 7. Mechanical forces and metabolic changes cooperate to drive cellular memory andendothelialphenotypes 199 Jin Li, Yun Fang, and David Wu 1. Introduction 200 2. Macrovascular flow andmetabolism 208
Contents vii 3. Microvasculature flow and metabolism 221 4. Stretch and metabolism 225 5. Stiffness and endothelial cell metabolism 225 6. Cytoskeletal regulation of metabolism 227 7. Discussion 230 Funding sources 232 References 232 8. Therapeutic perspectives of extraceiiular vesicles and extracellular microRNAs in atherosclerosis 255 Ya-Ju Chang and Kuei-Chun Wang Ί. Introduction 256 2. Overview of extracellular vesicles 259 3. Engineered EVs as delivery vehicles 262 4. Applications of EVs in treating cardiovascular pathologies 264 5. Extracellular miRNAs in atherosclerosis 266 6. Conclusion 269 Acknowledgment 269 References 269 9. Mechanotransduction in fibrosis: Mechanisms and treatment targets 279 Chih-Fan Yeh, Caroline Chou, and Kai-Chien Yang 1. Introduction 280 2. Tissue repair and fibrosis 281 3. Cell mechanoresponses relevant to fibrosis 283 4. Mechanotransduction through nucleo-cytoskeletal coupling 284 5. Biochemical signaling of mechanotransduction 286 6. Role of YAP/FAZ on mechanotransduction and fibrosis 286 7. Role of TGF-ß on mechanotransduction and fibrosis 290 8. Role of MRTF on mechanotransduction and fibrosis 291 9. Epigenetic regulator 292 10. EMT and EndoMT 293 11. Treatment target 294 12. Regulation of matrix stiffness and stability 295 13. Nuclear regulators (MRTFA, YAP, TAZ) 296 14. Matrix metalloproteinases (MMPs) 297 15. TGF-ß related integrins 298 16. Conclusion 299 References 299
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| any_adam_object | 1 |
| author2 | Fang, Yun |
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| discipline | Biologie |
| edition | First edition |
| format | Book |
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| id | DE-604.BV047609663 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T09:00:03Z |
| institution | BVB |
| isbn | 9780128215197 |
| language | English |
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| physical | xv, 314 Seiten Illustrationen, Diagramme |
| publishDate | 2021 |
| publishDateSearch | 2021 |
| publishDateSort | 2021 |
| publisher | Academic Press, an imprint of Elsevier |
| record_format | marc |
| series | Current topics in membranes |
| series2 | Current topics in membranes |
| spellingShingle | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases Current topics in membranes Fibrose (DE-588)4198241-1 gnd Plasmamembran (DE-588)4067550-6 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd Mechanische Kraftübertragung (DE-588)4169176-3 gnd |
| subject_GND | (DE-588)4198241-1 (DE-588)4067550-6 (DE-588)4024666-8 (DE-588)4169176-3 (DE-588)4143413-4 |
| title | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases |
| title_auth | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases |
| title_exact_search | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases |
| title_full | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases edited by Yun Fang, Committee on Molecular Metabolism and Nutrition, Biological Sciences Division; Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, United States |
| title_fullStr | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases edited by Yun Fang, Committee on Molecular Metabolism and Nutrition, Biological Sciences Division; Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, United States |
| title_full_unstemmed | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases edited by Yun Fang, Committee on Molecular Metabolism and Nutrition, Biological Sciences Division; Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, United States |
| title_short | Cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases |
| title_sort | cellular mechanotransduction mechanisms in cardiovascular and fibrotic diseases |
| topic | Fibrose (DE-588)4198241-1 gnd Plasmamembran (DE-588)4067550-6 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd Mechanische Kraftübertragung (DE-588)4169176-3 gnd |
| topic_facet | Fibrose Plasmamembran Kardiovaskuläre Krankheit Mechanische Kraftübertragung Aufsatzsammlung |
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