Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine
"Hepatitis C affects more than 100 million people worldwide and there is currently no vaccine against the virus that causes the disease (HCV). This volume describes recent advances in our understanding of the biology of HCV and the consequences of infection, as well as ongoing efforts to develo...
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| Sprache: | English |
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Cold Spring Harbor, New York
Cold Spring Harbor Laboratory Press
[2020]
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| Schriftenreihe: | Cold Spring Harbor perspectives in medicine
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| 653 | 0 | |a Hepatitis C virus | |
| 653 | 0 | |a Hepacivirus | |
| 653 | 0 | |a Hepatitis C / immunology | |
| 653 | 0 | |a Clinical Trials as Topic | |
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Datensatz im Suchindex
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| adam_text | Contents Preface, vii Hepatitis C Virus: 30 Years after Its Discovery, 1 Michael Houghton Hepatitis C Virus Structure: Defined by What It Is Not, 11 Akaira D. Dearborn and Joseph Marcotrigiano Cell Culture Systems of HCV Using JFH-1 and Other Strains, 25 Takají Wakita Animal Models of Hepatitis C Virus Infection, 37 Alexander Ploss and Amit Kapoor Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion, 53 Gisa Gerold, Rebecca Moeller, and Thomas Pietschmann Hepatitis C Virus Replication, 83 Keisuke Tabata, Christopher J. Neufeldt, and Ralf Bartenschlager HCV Assembly and Egress via Modifications in Host Lipid Metabolic Systems, 105 Kunitada Shimotohno Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis, 121 Alessia Virzi, Armando Andres Roca Suarez, Thomas F. Baumert, and Joachim Lupberger Innate Immunity in Hepatitis C Virus Infection, 139 Johannes Schwerk, Amina Negash, Ram Savan, and Michael Gale, Jr. Control of HCV Infection by Natural Killer Cells and Macrophages, 155 Hugo R. Rosen and Lucy Golden-Mason Т-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy, 1 71 Stephanie Smith, Jonathan R. Honegger, and Christopher Walker
Contents Antibody Responses in Hepatitis C Infection, 189 Mansun Law Interferon-Free Hepatitis C Virus Therapy, 209 Jean-Michel Pawlotsky Hepatitis C Virus Epidemiology and the impact of Interferon-Free Hepatitis C Virus Therapy, 223 Jeffrey Vi Lazarus, Elena Roel, and Ahmed M. Elsharkawy Natural History of Hepatic and Extrahepatic Hepatitis C Virus Diseases and Impact of Interferon-Free HCV Therapy, 237 Francesco Negro The Elimination of Hepatitis C as a Public Health Threat, 259 Margaret Hellard, Sophia E. Schroeder, Alisa Pedrana, Joseph Doyle, and Campbell Aitken Challenges and Promise of a Hepatitis C Virus Vaccine, 277 Andrea L. Cox Index, 293 VI
Hepatitis C Virus The Story of a Scientific and Therapeutic Revolution Hepatitis C is a liver disease caused by infection with the hepatitis C virus (HCV), a bloodborne pathogen. In some people, an immune response will clear the infection; however, in most, the infection becomes chronic and treatment with antiviral medication is necessary to prevent serious liver damage and cancer. The eradication of HCV will require improved access to diagnosis and treatment, an enhanced understanding of virus-host inter actions, and the development of an effective vaccine. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of the biology of HCV, the pathological consequences of infection, the current standard of hepatitis C treatment, and ongoing efforts to control the disease. Contribu tors discuss the structural and biochemical properties of HCV, the molecu lar details of its life cycle, and how it promotes liver disease by perturbing host cell signaling pathways. They likewise examine the innate and adap tive immune responses elicited by HCV and why those responses often fail to clear the infection. Direct-acting antiviral regimens to treat infected patients, the impacts of those treatments on hepatitis C epidemiology, and obstacles to HCV elimination (e.g., vaccine development) are also covered. This volume includes additional perspectives on the discovery of HCV, historical milestones in HCV research, and animal and cell culture models of HCV infection. It is an essential reference for virologists,
immunologists, and all clinical and laboratory investigators interested in eliminating HCV as a public health threat.
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| author | Pawlotsky, Jean-Michel |
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| id | DE-604.BV047037684 |
| illustrated | Illustrated |
| indexdate | 2025-02-03T15:58:23Z |
| institution | BVB |
| isbn | 9781621823193 1621823199 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032444820 |
| oclc_num | 1237593012 |
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| physical | vii, 297 Seiten Illustrationen 27 cm |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | marc |
| series2 | Cold Spring Harbor perspectives in medicine |
| spellingShingle | Pawlotsky, Jean-Michel Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine |
| title | Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_auth | Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_exact_search | Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_full | Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine edited by Arash Grakoui, Emory University, Jean-Michel Pawlotsky, University of Paris-Est, Glenn Randall, University of Chicago |
| title_fullStr | Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine edited by Arash Grakoui, Emory University, Jean-Michel Pawlotsky, University of Paris-Est, Glenn Randall, University of Chicago |
| title_full_unstemmed | Hepatitis C virus the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine edited by Arash Grakoui, Emory University, Jean-Michel Pawlotsky, University of Paris-Est, Glenn Randall, University of Chicago |
| title_short | Hepatitis C virus |
| title_sort | hepatitis c virus the story of a scientific and therapeutic revolution a subject collection from cold spring harbor perspectives in medicine |
| title_sub | the story of a scientific and therapeutic revolution : a subject collection from Cold Spring Harbor perspectives in medicine |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032444820&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032444820&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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