Cytochrome P450 Structure, Mechanism, and Biochemistry

This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two det...

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Veröffentlicht: Cham Springer International Publishing 2015
Ausgabe:4th ed. 2015
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500 |a Volume 1 -- 1 Structures of Cytochrome P450 Enzymes -- 2 Electron Transfer Partners of Cytochrome P450 -- 3 Activation of Molecular Oxygen in Cytochromes P450 -- 4 Substrate Oxidation by Cytochrome P450 Enzymes -- 5 Inhibition of Cytochrome P450 Enzymes -- 6 Microbial Cytochromes P450 -- 7 P450s in Plants, Insects and their Fungal Pathogens -- 8 P450 Biotechnology -- Volume 2 -- 9 Human Cytochrome P450 Enzymes -- 10 Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes -- 11 Hormonal Regulation of Liver Cytochrome P450 Enzymes -- 12 P450 Enzymes in Steroid Processing -- 13 P450 Enzymes in Lipid Oxidation 
520 |a This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems.   Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology 
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indexdate 2024-12-24T08:16:42Z
institution BVB
isbn 9783319121086
language English
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physical 1 Online Ressource (X, 912 Seiten, 243 Illustrationen, 80 Illustrationen in Farbe)
psigel ZDB-2-SME
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ZDB-2-SME ZDB-2-SME_2015
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publishDateSearch 2015
publishDateSort 2015
publisher Springer International Publishing
record_format marc
spellingShingle Cytochrome P450 Structure, Mechanism, and Biochemistry
Pharmacy
Biochemistry
Pharmacology
Cytochrom P-450 (DE-588)4148705-9 gnd
subject_GND (DE-588)4148705-9
title Cytochrome P450 Structure, Mechanism, and Biochemistry
title_auth Cytochrome P450 Structure, Mechanism, and Biochemistry
title_exact_search Cytochrome P450 Structure, Mechanism, and Biochemistry
title_full Cytochrome P450 Structure, Mechanism, and Biochemistry edited by Paul R. Ortiz de Montellano
title_fullStr Cytochrome P450 Structure, Mechanism, and Biochemistry edited by Paul R. Ortiz de Montellano
title_full_unstemmed Cytochrome P450 Structure, Mechanism, and Biochemistry edited by Paul R. Ortiz de Montellano
title_short Cytochrome P450
title_sort cytochrome p450 structure mechanism and biochemistry
title_sub Structure, Mechanism, and Biochemistry
topic Pharmacy
Biochemistry
Pharmacology
Cytochrom P-450 (DE-588)4148705-9 gnd
topic_facet Pharmacy
Biochemistry
Pharmacology
Cytochrom P-450
url https://doi.org/10.1007/978-3-319-12108-6
work_keys_str_mv AT ortizdemontellanopaulr cytochromep450structuremechanismandbiochemistry