Combination Therapy of AIDS
HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a hi...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Birkhäuser Basel
2004
|
| Schriftenreihe: | Milestones in Drug Therapy
|
| Schlagworte: | |
| Online-Zugang: | DE-355 URL des Erstveröffentlichers |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046148382 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 190906s2004 xx o|||| 00||| eng d | ||
| 020 | |a 9783034878692 |9 978-3-0348-7869-2 | ||
| 024 | 7 | |a 10.1007/978-3-0348-7869-2 |2 doi | |
| 035 | |a (ZDB-2-SBL)978-3-0348-7869-2 | ||
| 035 | |a (OCoLC)1118992519 | ||
| 035 | |a (DE-599)BVBBV046148382 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 615 |2 23 | |
| 084 | |a YD 8415 |0 (DE-625)153349:12921 |2 rvk | ||
| 245 | 1 | 0 | |a Combination Therapy of AIDS |c edited by Erik D. A. De Clercq, Anne-Mieke I. Vandamme |
| 264 | 1 | |a Basel |b Birkhäuser Basel |c 2004 | |
| 300 | |a 1 Online-Ressource (XI, 243 p) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Milestones in Drug Therapy | |
| 520 | |a HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system | ||
| 650 | 4 | |a Pharmacology/Toxicology | |
| 650 | 4 | |a Infectious Diseases | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Virology | |
| 650 | 4 | |a Medicine/Public Health, general | |
| 650 | 4 | |a Toxicology | |
| 650 | 4 | |a Emerging infectious diseases | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Medical virology | |
| 650 | 4 | |a Medicine | |
| 650 | 0 | 7 | |a Kombinationstherapie |0 (DE-588)4194534-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a HIV-Infektion |0 (DE-588)4203852-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Aids |0 (DE-588)4112470-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Aids |0 (DE-588)4112470-4 |D s |
| 689 | 0 | 1 | |a Kombinationstherapie |0 (DE-588)4194534-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a HIV-Infektion |0 (DE-588)4203852-2 |D s |
| 689 | 1 | 1 | |a Kombinationstherapie |0 (DE-588)4194534-7 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Clercq, Erik D. A. De |4 edt | |
| 700 | 1 | |a Vandamme, Anne-Mieke I. |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783034896047 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783764366001 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783034878708 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-0348-7869-2 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SBL | ||
| 940 | 1 | |q ZDB-2-SBL_2000/2004 | |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-031528559 | |
| 966 | e | |u https://doi.org/10.1007/978-3-0348-7869-2 |l DE-355 |p ZDB-2-SBL |q ZDB-2-SBL_2000/2004 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1819307131697889280 |
|---|---|
| any_adam_object | |
| author2 | Clercq, Erik D. A. De Vandamme, Anne-Mieke I. |
| author2_role | edt edt |
| author2_variant | e d a d c edad edadc a m i v ami amiv |
| author_facet | Clercq, Erik D. A. De Vandamme, Anne-Mieke I. |
| building | Verbundindex |
| bvnumber | BV046148382 |
| classification_rvk | YD 8415 |
| collection | ZDB-2-SBL |
| ctrlnum | (ZDB-2-SBL)978-3-0348-7869-2 (OCoLC)1118992519 (DE-599)BVBBV046148382 |
| dewey-full | 615 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615 |
| dewey-search | 615 |
| dewey-sort | 3615 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-0348-7869-2 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03739nam a2200661zc 4500</leader><controlfield tag="001">BV046148382</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">190906s2004 xx o|||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783034878692</subfield><subfield code="9">978-3-0348-7869-2</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-0348-7869-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SBL)978-3-0348-7869-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1118992519</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046148382</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615</subfield><subfield code="2">23</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YD 8415</subfield><subfield code="0">(DE-625)153349:12921</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Combination Therapy of AIDS</subfield><subfield code="c">edited by Erik D. A. De Clercq, Anne-Mieke I. Vandamme</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Basel</subfield><subfield code="b">Birkhäuser Basel</subfield><subfield code="c">2004</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XI, 243 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Milestones in Drug Therapy</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacology/Toxicology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Infectious Diseases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Virology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine/Public Health, general</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Emerging infectious diseases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medical virology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Kombinationstherapie</subfield><subfield code="0">(DE-588)4194534-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">HIV-Infektion</subfield><subfield code="0">(DE-588)4203852-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Aids</subfield><subfield code="0">(DE-588)4112470-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Aids</subfield><subfield code="0">(DE-588)4112470-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Kombinationstherapie</subfield><subfield code="0">(DE-588)4194534-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">HIV-Infektion</subfield><subfield code="0">(DE-588)4203852-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Kombinationstherapie</subfield><subfield code="0">(DE-588)4194534-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Clercq, Erik D. A. De</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vandamme, Anne-Mieke I.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783034896047</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783764366001</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783034878708</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-0348-7869-2</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SBL_2000/2004</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031528559</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-0348-7869-2</subfield><subfield code="l">DE-355</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="q">ZDB-2-SBL_2000/2004</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV046148382 |
| illustrated | Not Illustrated |
| indexdate | 2024-12-24T07:48:05Z |
| institution | BVB |
| isbn | 9783034878692 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031528559 |
| oclc_num | 1118992519 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (XI, 243 p) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2000/2004 ZDB-2-SBL ZDB-2-SBL_2000/2004 |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Birkhäuser Basel |
| record_format | marc |
| series2 | Milestones in Drug Therapy |
| spelling | Combination Therapy of AIDS edited by Erik D. A. De Clercq, Anne-Mieke I. Vandamme Basel Birkhäuser Basel 2004 1 Online-Ressource (XI, 243 p) txt rdacontent c rdamedia cr rdacarrier Milestones in Drug Therapy HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system Pharmacology/Toxicology Infectious Diseases Immunology Virology Medicine/Public Health, general Toxicology Emerging infectious diseases Medical virology Medicine Kombinationstherapie (DE-588)4194534-7 gnd rswk-swf HIV-Infektion (DE-588)4203852-2 gnd rswk-swf Aids (DE-588)4112470-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Aids (DE-588)4112470-4 s Kombinationstherapie (DE-588)4194534-7 s DE-604 HIV-Infektion (DE-588)4203852-2 s Clercq, Erik D. A. De edt Vandamme, Anne-Mieke I. edt Erscheint auch als Druck-Ausgabe 9783034896047 Erscheint auch als Druck-Ausgabe 9783764366001 Erscheint auch als Druck-Ausgabe 9783034878708 https://doi.org/10.1007/978-3-0348-7869-2 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Combination Therapy of AIDS Pharmacology/Toxicology Infectious Diseases Immunology Virology Medicine/Public Health, general Toxicology Emerging infectious diseases Medical virology Medicine Kombinationstherapie (DE-588)4194534-7 gnd HIV-Infektion (DE-588)4203852-2 gnd Aids (DE-588)4112470-4 gnd |
| subject_GND | (DE-588)4194534-7 (DE-588)4203852-2 (DE-588)4112470-4 (DE-588)4143413-4 |
| title | Combination Therapy of AIDS |
| title_auth | Combination Therapy of AIDS |
| title_exact_search | Combination Therapy of AIDS |
| title_full | Combination Therapy of AIDS edited by Erik D. A. De Clercq, Anne-Mieke I. Vandamme |
| title_fullStr | Combination Therapy of AIDS edited by Erik D. A. De Clercq, Anne-Mieke I. Vandamme |
| title_full_unstemmed | Combination Therapy of AIDS edited by Erik D. A. De Clercq, Anne-Mieke I. Vandamme |
| title_short | Combination Therapy of AIDS |
| title_sort | combination therapy of aids |
| topic | Pharmacology/Toxicology Infectious Diseases Immunology Virology Medicine/Public Health, general Toxicology Emerging infectious diseases Medical virology Medicine Kombinationstherapie (DE-588)4194534-7 gnd HIV-Infektion (DE-588)4203852-2 gnd Aids (DE-588)4112470-4 gnd |
| topic_facet | Pharmacology/Toxicology Infectious Diseases Immunology Virology Medicine/Public Health, general Toxicology Emerging infectious diseases Medical virology Medicine Kombinationstherapie HIV-Infektion Aids Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-0348-7869-2 |
| work_keys_str_mv | AT clercqerikdade combinationtherapyofaids AT vandammeannemiekei combinationtherapyofaids |