Mitochondrial dysfunction in neurodegeneration and periphal neuropathies
"Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the...
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| Sprache: | English |
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Cambridge, MA
Academic Press, an imprint of Elsevier
2019
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| Ausgabe: | First edition |
| Schriftenreihe: | International review of neurobiology
volume 145 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Mitochondrial dysfunction in neurodegeneration and periphal neuropathies |c edited by Paul Fernyhough, Nigel A. Calcutt |
| 250 | |a First edition | ||
| 264 | 1 | |a Cambridge, MA |b Academic Press, an imprint of Elsevier |c 2019 | |
| 300 | |a xiii, 238 Seiten |b Illustrationen | ||
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| 490 | 1 | |a International review of neurobiology |v volume 145 | |
| 500 | |a Literaturangaben | ||
| 520 | 3 | |a "Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation"-- publisher's website | |
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Datensatz im Suchindex
| _version_ | 1804180370053136384 |
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| adam_text | Contents Contributors ix Preface xi Acknowledgments xiii 1. Mitochondriopathy: The unifying concept in distal neuropathies? 1 Robert E. Schmidt 1. Introduction 2 2. Mitochondriopathy in peripheral neuropathy: Overview 3 3. Recent basic science contributions to understanding and treatment of peripheral neuropathy 4 4. Autonomic nervous system: Diabetes and aging inrodents 6 5. Synopses of the chapters References 8 - 10 2. Dysfunction of mitochondria: Implications for Alzheimer s disease 13 Benedict C. Albensi 1. What is Alzheimer s disease? 14 2. Mitochondrial cascade 15 3. Mechanisms of mitochondrial dysfunction 16 4. Mitochondrial medicine in Alzheimer s disease 23 5. Conclusions 24 Acknowledgments 24 References 24 3. HIV in the cART era and the mitochondrial: immune interface in the CNS 29 Jerel Adam Fields and Ronald J. Ellis 1. Introduction 30 2. HIV proteins and mitochondrial dysfunction in the CNS 38 3. cART and mitochondrial dysfunction in the CNS 48 4. Preventing HIV-induced mitochondrial toxicity 51 5. Conclusion 54 References 55 v
Contents VI 4. Mitochondrial dysfunction in HIV-induced peripheral neuropathy 67 Ricardo H. Roda and Ahmet Hoke 1. Introduction 68 2. Mitochondrial abnormalities in HIV peripheral neuropathy 69 3. mtDNA variation and HIV-SN 76 4. Mitochondrial fusion and fission 77 5. 77 Future directions References 78 5. Mitochondrial dysfunction in the pathogenesis of chemotherapy-induced peripheralneuropathy 83 Annalisa Trecarichi and Sarah J.L. Flatters 1. Introduction 84 2. Nature of mitochondrial dysfunction evoked by chemotherapy 90 3. Counteracting mitochondrial dysfunctionvia pharmacological interventions 102 4. Conclusion 116 References 116 6. Disorders of mitochondrial dynamics in peripheral neuropathy: Clues from hereditary neuropathy anddiabetes 127 Amy E. Rumora, Masha G. Savelieff, Stacey A. Sakowski, and Eva L Feldman 1. Introduction 128 2. Mitochondrial dynamics 130 3. Mitochondrial dynamics in disease 4. Regulation of mitochondrial dynamics by 5. Regulation of mitochondrial dynamics by 6. Conclusions 139 glucose dyslipidemia 151 153 161 Acknowledgments 162 References 162 7. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRTI -PGC-la-TFAM pathway 177 Krish Chandrasekaran, Muragundla Anjaneyulu, Joungil Choi, Pranith Kumar, Mohammad Salimian, Cheng-Ying Ho, and James W. Russell 1. Introduction 178 2. Mitochondrial hypothesis of diabetic peripheralneuropathy 179
Contents vii 3. Control of mitochondrial biogenesis: The SIRTI ~PGC-1a-TFAM axis 4. PGC1-a in neuropathy: Effect on diabetes and lipid metabolism 182 181 5. Neuropathy is more severe in diabetic PGC-1 a knockout mice 184 6. Effect of PGC-1 a knockout on mitochondrial function in diabetic neuropathy 185 7. TFAM and mtDNA: Transcription, replication, and protection 186 8. Overexpression of human TFAM protects against DPN 187 9. Administration of the mGluR 2/3 agonist, LY379268, protects against DPN 189 10. Role of NAD+analogues in DPN 194 11. The choice of NAD+ precursor is critical 195 12. SIRT1 and DPN 197 13. Conclusion 199 Acknowledgments 199 References 199 8. Dichloroacetate-induced peripheral neuropathy 211 Peter W. Stacpoole, Christopher J. Martyniuk, Margaret 0. James, and Nigel A. Calcutt 1. Introduction 212 2. Dichloroacetate pharmacokinetics and metabolism 213 3. Dichloroacetate pharmacodynamics and clinicalutility 214 4. Dichloroacetate toxicity and neuropathy 218 5. Future avenues of potential research 228 6. Summary 232 References 233 Further reading 238
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| indexdate | 2024-07-10T08:34:41Z |
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| isbn | 9780128172247 |
| language | English |
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| spelling | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies edited by Paul Fernyhough, Nigel A. Calcutt First edition Cambridge, MA Academic Press, an imprint of Elsevier 2019 xiii, 238 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier International review of neurobiology volume 145 Literaturangaben "Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation"-- publisher's website Nervendegeneration (DE-588)4300182-8 gnd rswk-swf Mitochondriopathie (DE-588)4280150-3 gnd rswk-swf Mitochondrial pathology Nervous system / Degeneration Nervous system / Diseases Neurology (DE-588)4143413-4 Aufsatzsammlung gnd-content Nervendegeneration (DE-588)4300182-8 s Mitochondriopathie (DE-588)4280150-3 s b DE-604 Fernyhough, Paul edt Calcutt, Nigel A. edt Erscheint auch als Online-Ausgabe 978-0-12-817225-4 International review of neurobiology volume 145 (DE-604)BV002534817 145 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031462517&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies International review of neurobiology Nervendegeneration (DE-588)4300182-8 gnd Mitochondriopathie (DE-588)4280150-3 gnd |
| subject_GND | (DE-588)4300182-8 (DE-588)4280150-3 (DE-588)4143413-4 |
| title | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies |
| title_auth | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies |
| title_exact_search | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies |
| title_full | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies edited by Paul Fernyhough, Nigel A. Calcutt |
| title_fullStr | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies edited by Paul Fernyhough, Nigel A. Calcutt |
| title_full_unstemmed | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies edited by Paul Fernyhough, Nigel A. Calcutt |
| title_short | Mitochondrial dysfunction in neurodegeneration and periphal neuropathies |
| title_sort | mitochondrial dysfunction in neurodegeneration and periphal neuropathies |
| topic | Nervendegeneration (DE-588)4300182-8 gnd Mitochondriopathie (DE-588)4280150-3 gnd |
| topic_facet | Nervendegeneration Mitochondriopathie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031462517&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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