The ubiquitin-proteasome proteolytic system from classical biochemistry to human diseases
Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, which includes: the cell cycle; cell growth and differentiation; embryogenesis; apoptosis; signal transduction; DNA repair; regulation of transcription and DNA replication; transmembrane...
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| Format: | Elektronisch E-Book |
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| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
c2002
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| Schriftenreihe: | Recent advances in human biology
v. 9 |
| Schlagworte: | |
| Online-Zugang: | DE-92 URL des Erstveroeffentlichers |
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| Zusammenfassung: | Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, which includes: the cell cycle; cell growth and differentiation; embryogenesis; apoptosis; signal transduction; DNA repair; regulation of transcription and DNA replication; transmembrane transport; endocytosis; stress responses; antigen presentation and other aspects of the immune response; the functions of the nervous system including circadian rhythms; axon guidance and acquisition of memory. This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes |
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| Beschreibung: | xx, 220 p. ill |
| ISBN: | 9789812776877 |