Natural products targeting clinically relevant enzymes
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[2017]
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| 245 | 1 | 0 | |a Natural products targeting clinically relevant enzymes |c edited by Paula B. Andrade, Patrícia Velentão, David M. Pereira |
| 264 | 1 | |a Weinheim, Germany |b Wiley-VCH |c [2017] | |
| 264 | 4 | |c © 2017 | |
| 300 | |a xvii, 329 Seiten |b Illustrationen (teilweise farbig) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 653 | |a Biochemie | ||
| 653 | |a Biochemistry | ||
| 653 | |a Biowissenschaften | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Drug Discovery & Development | ||
| 653 | |a Life Sciences | ||
| 653 | |a Medical Science | ||
| 653 | |a Medizin | ||
| 653 | |a Pharmacology & Pharmaceutical Medicine | ||
| 653 | |a Pharmakologie u. Pharmazeutische Medizin | ||
| 653 | |a Wirkstoffforschung u. -entwicklung | ||
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| 700 | 1 | |a Andrade, Paula B. |0 (DE-588)1142547329 |4 edt | |
| 700 | 1 | |a Valentão, Patrícia |0 (DE-588)1142547728 |4 edt | |
| 700 | 1 | |a Pereira, David M. |0 (DE-588)1142548023 |4 edt | |
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, Mobi |z 978-3-527-80594-5 |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-029989567 | |
Datensatz im Suchindex
| _version_ | 1819596454198509568 |
|---|---|
| adam_text | CONTENTS
LIST OF CONTRIBUTORS XIII
1 NATURAL PRODUCTS AS ENZYME INHIBITORS 1
DAVID M. PEREIRA, CATARINA ANDRADE, PATRICIA VALENTAO, AND PAULA B.
ANDRADE
1.1 WHY ARE NATURAL PRODUCTS GOOD ENZYME INHIBITORS? 1
1.2 DRAWBACKS OF NATURAL PRODUCTS 4
1.3 THE FUTURE OF NATURAL PRODUCTS DRUG DISCOVERY 5
1.3.1 NEW SOURCES AND NEW PRODUCTION METHODS 5
1.3.2 NEW STRATEGIES FOR DELIVERY 9
1.3.3 NEW TARGETS?/DRUG REPURPOSING 12
1.4 CONCLUSION 13
REFERENCES 13
2 MOLECULAR TARGETS OF CLINICALLY RELEVANT NATURAL PRODUCTS
FROM FILAMENTOUS MARINE CYANOBACTERIA 19
LIK TONG TAN
2.1 INTRODUCTION 19
2.2 HISTONE DEACETYLASE INHIBITORS 20
2.2.1 LARGAZOLE 20
2.2.2 SANTACRUZAMATE A 22
2.3 PROTEASOME INHIBITORS 23
2.3.1 CARMAPHYCINS 23
2.4 PROTEASE ENZYMES 24
2.4.1 SERINE PROTEASE INHIBITORS 24
2.4.2 FALCIPAIN INHIBITORS 27
2.4.2.1 GALLINAMIDE A 27
2.4.3 CATHEPSIN INHIBITORS 28
2.4.4 SS-SECRETASE 1 (BACE1) INHIBITORS 30
2.4.4.1 TASIAMIDE B 30
2.5 PROTEIN KINASE C MODULATORS 30
2.5.1 APLYSIATOXINS 30
2.6 INTERFERENCE OF THE ACTIN AND MICROTUBULE FILAMENTS 31
2.6.1 DOLASTATINS 10/15 31
2.6.2 BISEBROMOAMIDE 32
2.7 SEC61 PROTEIN TRANSLOCATION CHANNEL INHIBITORS 32
2.7.1 APRATOXIN A 32
2.8 PROHIBITIN INHIBITORS 34
2.8.1 AURILIDE 34
2.9 SODIUM CHANNELS MODULATORS 35
2.10 CONCLUSIONS 35
REFERENCES 36
3 NATURAL ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS
WITH ANTIHYPERTENSIVE PROPERTIES 45
MARIA MARGATE!, FRANCISCO /. BRAVO, ANNA AROLA-ARNAL, AND BEGOHA
MUGUERZA
3.1 INTRODUCTION 45
3.2 MECHANISMS OF BLOOD PRESSURE REGULATION 46
3.2.1 RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 46
3.3 THE TREATMENT OF HYPERTENSION 47
3.3.1 ANGIOTENSIN CONVERTING ENZYME INHIBITORS 47
3.4 NATURAL PRODUCTS AS ANGIOTENSIN CONVERTING ENZYME INHIBITORS 50
3.4.1 POLYPHENOLS 50
3.4.2 PROTEIN DERIVED PEPTIDES 55
3.5 CONCLUSIONS 58
REFERENCES 58
4 PHOSPHOLIPASE A2 INHIBITORS OF MARINE ORIGIN 69
TANIA C.
SILVA, DAVID M. PEREIRA, PATRICIA VALENTAO, AND PAULA B. ANDRADE
4.1 RELEVANCE OF MARINE ORGANISMS 69
4.2 INFLAMMATION 69
4.2.1 PHOSPHOLIPASE A2 70
4.3 MARINE MOLECULES AS PLA2 INHIBITORS 72
4.3.1 SPONGE-DERIVED METABOLITES 72
4.3.2 METABOLITES FROM OTHER ORGANISMS 83
4.4 CONCLUSION 86
REFERENCES 86
5 SS-SECRETASE (BACE1) INHIBITORS FROM NATURAL PRODUCTS 93
WEI-SHUO FANG, DEYANG SUN, SHUANG YANG, AND NA GUO
5.1 INTRODUCTION 93
5.2 FLAVONOIDS 94
5.2.1 FLAVONES, FLAVONOLS AND FLAVONE GLYCOSIDES 95
5.2.2 DIHYDROFLAVONOIDS 96
5.2.3 BIFLAVONOIDS 93
5.2.4 CHALCONES 100
5.2.5 ISOFLAVONOIDS 102
5.2.6 CATECHINS 102
5.2.7 XANTHONES 104
5.3 CHROMONES 104
5.4 PHENOLIC ACIDS AND TANNINS 105
5.4.1 PHENOL ACIDS 105
5.4.2 TANNINS 106
5.4.3 SIMPLE PHENOL DERIVATIVES AND POLYPHENOLS 107
5.5 STILBENES AND DERIVATIVES 110
5.6 COUMARINS 112
5.7 BENZOQUINONES AND ANTHRAQUINONES 114
5.8 ALKALOIDS 116
5.9 TERPENES 118
5.10 LIGNANS 120
5.11 FATTY ACID 121
5.12 SACCHARIDES, PEPTIDES AND AMINO ACID DERIVATIVES 121
5.13 BACE1 INHIBITORY ACTIVE EXTRACTS OF NATURAL PRODUCTS 122
5.14 BIOASSAYS FOR THE DISCOVERY OF BACE1 INHIBITORS 124
5.15 PROSPECTIVE 124
5.16 ACKNOWLEDGEMENTS 125
REFERENCES 125
6 HYPOGLYCAEMIC EFFECTS OF PLANTS FOOD CONSTITUENTS VIA INHIBITION
OF CARBOHYDRATE-HYDROLYSING ENZYMES: FROM CHEMISTRY TO FUTURE
APPLICATIONS 135
MONICA R. LOIZZO, MARCO BONESI, SEYED M. NABAVI,
EDUARDO SOBARZO-SANCHEZ, LUCA RASTRELLI, AND ROSA TUNDIS
6.1 INTRODUCTION 135
6.2 A-AMYLASE 136
6.3 A-GLUCOSIDASE 137
6.4 HYPOGLYCAEMIC NATURAL COMPOUNDS 137
6.4.1 FLAVONOIDS 139
6.4.2 PHENOLIC ACIDS 141
6.4.3 TERPENOIDS 142
6.4.4 ALKALOIDS 147
6.4.5 TANNINS 150
6.4.5.1 ELLAGITANNINS 150
6.4.6 MISCELLANEOUS 152
6.5 CONCLUSIONS AND FUTURE PERSPECTIVE 152
ABBREVIATIONS 153
REFERENCES 153
7 NATURAL PRODUCTS TARGETING CLINICALLY RELEVANT ENZYMES OF EICOSANOID
BIOSYNTHESIS IMPLICATED IN INFLAMMATION AND CANCER 163
GORLA V. REDDY NAGENDRA 5. YARIA, SHOBHA EDIGA, DINESH K. TIWARI,
NARESH KUMAR, SANDHYA 5INGH, VASUNDHRA BHANDARI, PRIYANKA VOORI GIRI,
ANUPAM BISHAYEE, CHINTALAPALLY V. RAO, AND PALLU REDDANNA
7.1 INTRODUCTION 163
7.2 EICOSANOID BIOSYNTHETIC PATHWAYS 164
7.2.1 PHOSPHOLIPASES 165
7.2.2 CYCLOOXYGENASES 166
7.2.3 LIPOXYGENASES 166
7.2.4 CYTOCHROME P450 (CYP)-DEPENDENT MONOOXYGENASES 166
7.3 EICOSANOID BIOSYNTHETIC PATHWAYS IN INFLAMMATION AND CANCER 167
7.3.1 ROLE OF PLA2
S
IN INFLAMMATION AND CANCER 167
7.3.2 ROLE OF COXS IN INFLAMMATION AND CANCER 168
7.3.3 ROLE OF LOXS IN INFLAMMATION AND CANCER 169
7.3.4 ROLE OF CYP-DEPENDENT MONOOXYGENASES IN INFLAMMATION
AND CANCER 170
7.4 NATURAL PRODUCTS AS ANTI-INFLAMMATORY AGENTS 170
7.4.1 NATURAL PRODUCTS FROM PLANT ORIGIN 170
7.4.1.1 BAICALEIN 170
7.4.1.2 BERBER INE 171
7.4.1.3 CHEBULAGIC ACID 172
7.4.1.4 CURCUMIN 172
7.4.1.5 ELLAGIC ACID 173
7.4.1.6 EPIGALLOCATECHIN-3-GALLATE 174
7.4.1.7 EUGENOL 174
7.4.1.8 FISETIN 174
7.4.1.9 GALLIC ACID 175
7.4.1.10 GENISTEIN 175
7.4.1.11 GUGGULSTERONE 176
7.4.1.12 PIPERINE 176
7.4.1.13 QUERCETIN 177
7.4.1.14 RESVERATROL 178
7.4.1.15 SILIBININ 178
7.4.1.16 TERPENOIDS 179
7.4.1.17 TRIPTOLIDS 180
7.4.1.18 URSOLIC ACID (UA) 181
7.4.2 NATURAL PRODUCTS FROM MARINE ORIGIN 182
7.4.2.1 AXINELLINEA 182
7.4.2.2 SCALARADIAL 182
7.4.2.3 TETRAPETALONE 183
7.4.3 NATURAL PRODUCTS FROM MICROORGANISMS 183
7.4.3.1 C-PHYCOCYANIN 183
7.4.3.2 KOJIC ACID 184
7.4.3.3 LOBARIC ACID 185
7.5 CONCLUSIONS AND FUTURE DIRECTIONS 185
REFERENCES 186
8 ANTI-HIV NATURAL PRODUCTS 209
JACK HO WONG, TZI BUN NG, CHI FAI CHEUNG, CHIT TAM, CHARLENE C. W. NG,
RYAN TSE, TAK FU TSE, AND HELEN CHAN
8.1 INTRODUCTION 209
8.2 RIBOSOME-INACTIVATING PROTEINS 209
8.3 REVERSE TRANSCRIPTASE INHIBITORS 210
8.3.1 ANTIFUNGAL PROTEINS 210
8.3.2 DEFENSINS AND DEFENSIN-LIKE ANTI-FUNGAL PEPTIDES 210
8.3.3 CATHELICIDINS 210
8.3.4 WHEY PROTEINS AND PEPTIDES 211
8.3.5 PROTEASES AND PROTEASE INHIBITORS 211
8.3.6 LECTINS 211
8.3.7 LACCASES AND RIBONUCLEASES 212
8.3.8 POLYSACCHARIDES AND POLYSACCHAROPEPTIDES 212
8.3.9 OTHER HIV-REVERSE TRANSCRIPTASE INHIBITORS 212
8.4 INHIBITORS OF HIV REVERSE TRANSCRIPTASE ASSOCIATED RNASE H 213
8.5 HIV-1 PROTEASE INHIBITORS 213
8.6 HIV-1 INTEGRASE INHIBITORS 214
8.7 DISCUSSION 214
ACKNOWLEDGEMENTS 216
REFERENCES 216
9 NATURAL INHIBITORS OF MITOCHONDRIAL RESPIRATORY CHAIN: THERAPEUTIC
AND TOXICOLOGICAL IMPLICATIONS 225
FERNANDO PELAEZ, NURIA DE PEDRO, AND JOSE R. TORMO
9.1 INTRODUCTION: THE STRUCTURE OF THE ELECTRON TRANSPORT
CHAIN 225
9.2 NATURAL INHIBITORS OF THE RESPIRATORY CHAIN 228
9.2.1 COMPLEX I INHIBITORS 228
9.2.1.1 ACETOGENINS FROM ANNONACEAE AS COMPLEX I INHIBITORS 231
9.2.2 COMPLEX II INHIBITORS 233
9.2.3 COMPLEX III INHIBITORS 234
9.2.4 COMPLEX IV INHIBITORS 235
9.2.5 COMPLEX V INHIBITORS 237
9.3 THERAPEUTIC, AGROCHEMICAL AND TOXICOLOGICAL IMPLICATIONS 239
9.3.1 ETC INHIBITORS AS FUNGICIDES 239
9.3.2 ETC INHIBITORS AS INSECTICIDES, ACARICIDES, AND ANTHELMINTIC
AGENTS 240
9.3.3 ETC INHIBITORS WITH ACTIVITY AGAINST PROTOZOAN PARASITES 241
9.3.4 DIABETES AND ETC INHIBITION 241
9.3.5 ETC INHIBITION AS A THERAPEUTIC STRATEGY IN CANCER 242
9.3.5.1 MECHANISTIC INSIGHTS ON THE ANTI-TUMOUR PROPERTIES
OF ETC INHIBITORS 244
9.3.6 TOXICOLOGICAL IMPLICATIONS OF ETC INHIBITION 245
9.3.6.1 NEUROTOXICITY AND ETC INHIBITION 245
9.3.6.2 OTHER TOXICITY ASPECTS OF ETC INHIBITION 246
9.4 CONCLUSIONS 247
REFERENCES 247
10 TARGETING ENZYMATIC PATHWAYS WITH MARINE-DERIVED
CLINICAL AGENTS 255
RENATO 8. PEREIRA, RAMESH DASARI, FLORENCE LEFRANC, ALEXANDER KORNIENKO,
ROBERT KISS, AND NELSON G.
M. GOMES
10.1 MARINE ENVIRONMENT AS AN ESTABLISHED SOURCE OF DRUG
CANDIDATES 255
10.2 ENZYME-TARGETING DERIVED EFFECTS OF MARINE-DERIVED APPROVED
DRUGS 256
10.3 MARINE-DERIVED AGENTS IN CLINICAL DEVELOPMENT TARGETING RELEVANT
ENZYMATIC PATHWAYS 261
10.4 CONCLUDING REMARKS 264
ACKNOWLEDGEMENTS 265
REFERENCES 265
11 ANTI-MALARIAL DRUG DISCOVERY: NEW ENZYME INHIBITORS 277
RAGHU RAJ AND VIPAN KUMAR
11.1 INTRODUCTION 277
11.2 FALCIPAIN (FP-2) INHIBITORS 278
11.3 PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS (PNP) 284
11.4 DIHYDROFOLATE REDUCTASE (DHFR) AND THYMIDYLATE SYNTHASE (TS)
INHIBITORS 286
11.5 HYPOXANTHINE-GUANINE-(XANTHINE) PHOSPHORIBOSYLTRANSFERASE
INHIBITORS 290
11.6 CONCLUSION 293
ACKNOWLEDGEMENTS 293
REFERENCES 293
12 NATURAL PLANT-DERIVED ACETYLCHOLINESTERASE INHIBITORS: RELEVANCE
FOR ALZHEIMER S DISEASE 297
NADY BRAIDY, ANNE POLJAK, THARUSHA JAYASENA, AND PERMINDER SACH DEV
12.1 INTRODUCTION 297
12.2 NATURAL ACETYLCHOLINESTERASE INHIBITORS 299
12.2.1 ALKALOID ACETYLCHOLINESTERASE INHIBITORS 302
12.2.1.1 RUTACEAE 302
12.2.1.2 NELUMBONACEAE 303
12.2.1.3 PAPAVERACEAE 303
12.2.1.4 MENISPERMACEAE 303
12.2.1.5 MAGNOLIACEAE 304
12.2.1.6 APOCYNACEAE 304
12.2.1.7 AMARYLLIDACEAE 304
12.2.1.8 LYCOPODIACEAE 305
12.2.1.9 BUXACEAE 305
12.2.1.10 LILIACEAE 306
12.2.2 NON-ALKALOID ACETYLCHOLINESTERASE INHIBITORS 306
12.2.2.1 ASPARAGACEAE 306
12.2.2.2 CHENOPODIACEAE 306
12.2.2.3 CLUSIACEAE 307
12.2.2.4 GENTIANACEAE 307
12.2.2.5 FABACEAE 307
12.2.2.6 LAMIACEAE 307
12.2.2.7 MORACEAE 308
12.2.2.8 IRIDACEAE 308
12.2.2.9 ZYGOPHYLLACEAE 308
12.2.2.10 STERCULIACEAE 308
12.2.2.11 COMBRETACEAE 309
12.2.2.12 MYRISTICACEAE 309
12.2.2.13 ANACARDIACEAE 309
12.2.2.14 NELUMBONACEAE 309
12.3 CONCLUSION 309
ACKNOWLEDGEMENTS 309
REFERENCES 310
INDEX 319
|
| any_adam_object | 1 |
| author2 | Andrade, Paula B. Valentão, Patrícia Pereira, David M. |
| author2_role | edt edt edt |
| author2_variant | p b a pb pba p v pv d m p dm dmp |
| author_GND | (DE-588)1142547329 (DE-588)1142547728 (DE-588)1142548023 |
| author_facet | Andrade, Paula B. Valentão, Patrícia Pereira, David M. |
| building | Verbundindex |
| bvnumber | BV044591104 |
| classification_rvk | VK 8500 VK 8700 VS 7000 WD 5050 |
| ctrlnum | (OCoLC)979560352 (DE-599)DNB1127653741 |
| dewey-full | 540 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
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| discipline | Chemie / Pharmazie Biologie |
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Pharmazeutische Medizin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Wirkstoffforschung u. -entwicklung</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Naturstoff</subfield><subfield code="0">(DE-588)4041418-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Antagonist</subfield><subfield code="0">(DE-588)4198647-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Andrade, Paula B.</subfield><subfield code="0">(DE-588)1142547329</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Valentão, Patrícia</subfield><subfield code="0">(DE-588)1142547728</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pereira, David M.</subfield><subfield code="0">(DE-588)1142548023</subfield><subfield code="4">edt</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Wiley-VCH</subfield><subfield code="0">(DE-588)16179388-5</subfield><subfield code="4">pbl</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, ePDF</subfield><subfield code="z">978-3-527-80591-4</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, ePub</subfield><subfield code="z">978-3-527-80593-8</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, Mobi</subfield><subfield code="z">978-3-527-80594-5</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, oBook</subfield><subfield code="z">978-3-527-80592-1</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029989567&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029989567</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV044591104 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T06:11:47Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527342051 3527342052 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029989567 |
| oclc_num | 979560352 |
| open_access_boolean | |
| owner | DE-11 DE-19 DE-BY-UBM |
| owner_facet | DE-11 DE-19 DE-BY-UBM |
| physical | xvii, 329 Seiten Illustrationen (teilweise farbig) |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Wiley-VCH |
| record_format | marc |
| spellingShingle | Natural products targeting clinically relevant enzymes Naturstoff (DE-588)4041418-8 gnd Antagonist (DE-588)4198647-7 gnd |
| subject_GND | (DE-588)4041418-8 (DE-588)4198647-7 (DE-588)4143413-4 |
| title | Natural products targeting clinically relevant enzymes |
| title_auth | Natural products targeting clinically relevant enzymes |
| title_exact_search | Natural products targeting clinically relevant enzymes |
| title_full | Natural products targeting clinically relevant enzymes edited by Paula B. Andrade, Patrícia Velentão, David M. Pereira |
| title_fullStr | Natural products targeting clinically relevant enzymes edited by Paula B. Andrade, Patrícia Velentão, David M. Pereira |
| title_full_unstemmed | Natural products targeting clinically relevant enzymes edited by Paula B. Andrade, Patrícia Velentão, David M. Pereira |
| title_short | Natural products targeting clinically relevant enzymes |
| title_sort | natural products targeting clinically relevant enzymes |
| topic | Naturstoff (DE-588)4041418-8 gnd Antagonist (DE-588)4198647-7 gnd |
| topic_facet | Naturstoff Antagonist Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029989567&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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