Retinoids their physiological function and therapeutic potential
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| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Greenwich, Conn.
JAI Press
1997
|
| Schriftenreihe: | Advances in organ biology
v. 3 |
| Schlagworte: | |
| Online-Zugang: | DE-1046 URL des Erstveröffentlichers |
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| 245 | 1 | 0 | |a Retinoids |b their physiological function and therapeutic potential |c guest editor, G.V. Sherbet |
| 264 | 1 | |a Greenwich, Conn. |b JAI Press |c 1997 | |
| 300 | |a xiv, 297 pages | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Advances in organ biology |v v. 3 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. | ||
| 500 | |a The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. | ||
| 500 | |a This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here | ||
| 650 | 4 | |a Retinoids / pharmacokinetics | |
| 650 | 4 | |a Retinoids / therapeutic use | |
| 650 | 4 | |a Retinoids | |
| 650 | 4 | |a Therapeutic use | |
| 650 | 7 | |a MEDICAL / Physiology |2 bisacsh | |
| 650 | 7 | |a SCIENCE / Life Sciences / Human Anatomy & Physiology |2 bisacsh | |
| 650 | 7 | |a Retinoids |2 fast | |
| 650 | 7 | |a Retinoids / Therapeutic use |2 fast | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Retinoids | |
| 650 | 4 | |a Retinoids |x Therapeutic use | |
| 700 | 1 | |a Sherbet, G. V. |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| dewey-full | 612 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612 |
| dewey-search | 612 |
| dewey-sort | 3612 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV044384621 |
| illustrated | Not Illustrated |
| indexdate | 2024-12-24T05:59:14Z |
| institution | BVB |
| isbn | 9780080877174 0080877176 0762302852 9780762302857 1281716693 9781281716699 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029786842 |
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| owner_facet | DE-1046 |
| physical | xiv, 297 pages |
| psigel | ZDB-33-ESD ZDB-33-ESD FAW_PDA_ESD |
| publishDate | 1997 |
| publishDateSearch | 1997 |
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| publisher | JAI Press |
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| series2 | Advances in organ biology |
| spelling | Retinoids their physiological function and therapeutic potential guest editor, G.V. Sherbet Greenwich, Conn. JAI Press 1997 xiv, 297 pages txt rdacontent c rdamedia cr rdacarrier Advances in organ biology v. 3 Includes bibliographical references and index Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here Retinoids / pharmacokinetics Retinoids / therapeutic use Retinoids Therapeutic use MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Retinoids fast Retinoids / Therapeutic use fast Medizin Retinoids Therapeutic use Sherbet, G. V. Sonstige oth http://www.sciencedirect.com/science/bookseries/15692590/3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Retinoids their physiological function and therapeutic potential Retinoids / pharmacokinetics Retinoids / therapeutic use Retinoids Therapeutic use MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Retinoids fast Retinoids / Therapeutic use fast Medizin Retinoids Therapeutic use |
| title | Retinoids their physiological function and therapeutic potential |
| title_auth | Retinoids their physiological function and therapeutic potential |
| title_exact_search | Retinoids their physiological function and therapeutic potential |
| title_full | Retinoids their physiological function and therapeutic potential guest editor, G.V. Sherbet |
| title_fullStr | Retinoids their physiological function and therapeutic potential guest editor, G.V. Sherbet |
| title_full_unstemmed | Retinoids their physiological function and therapeutic potential guest editor, G.V. Sherbet |
| title_short | Retinoids |
| title_sort | retinoids their physiological function and therapeutic potential |
| title_sub | their physiological function and therapeutic potential |
| topic | Retinoids / pharmacokinetics Retinoids / therapeutic use Retinoids Therapeutic use MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Retinoids fast Retinoids / Therapeutic use fast Medizin Retinoids Therapeutic use |
| topic_facet | Retinoids / pharmacokinetics Retinoids / therapeutic use Retinoids Therapeutic use MEDICAL / Physiology SCIENCE / Life Sciences / Human Anatomy & Physiology Retinoids / Therapeutic use Medizin Retinoids Therapeutic use |
| url | http://www.sciencedirect.com/science/bookseries/15692590/3 |
| work_keys_str_mv | AT sherbetgv retinoidstheirphysiologicalfunctionandtherapeuticpotential |