Integrated cardiac safety assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J.
John Wiley & Sons
c2009
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Inhaltsangabe:
- The importance of cardiac safety assessments
- The biological basis of adverse drug reactions
- Cardiac structure and function
- Cardiac pathophysiology and disease
- Drug discovery and drug design
- Nonclinical development
- The thorough QT/QTc trial
- General safety assessments
- Therapeutic use trials and meta-analyses
- Assessment methodologies in nonexperimental postmarketing surveillance
- Postmarketing proarrhythmic cardiac safety assessments
- Generalized cardiac safety
- Medication errors, adherence, and concordance
- Future directions in drug safety