Antibiotics challenges, mechanisms, opportunities
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| Hauptverfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Washington, DC
ASM Press
[2016]
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| Online-Zugang: | Inhaltsverzeichnis Klappentext |
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| 100 | 1 | |a Walsh, Christopher |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Antibiotics |b challenges, mechanisms, opportunities |c by Christopher Walsh and Timothy Wencewicz |
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| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Antibiotics |2 cabt | |
| 650 | 4 | |a Antibiotiques | |
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| 650 | 4 | |a Micro-organismes - Résistance aux médicaments | |
| 650 | 7 | |a Resistência microbiana às drogas |2 larpcal | |
| 650 | 4 | |a Anti-Bacterial Agents |x pharmacology | |
| 650 | 4 | |a Antibiotics | |
| 650 | 4 | |a Drug Resistance, Bacterial | |
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Datensatz im Suchindex
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| _version_ | 1823056500920156160 |
| adam_text | Preface ix-x
Section I Challenges for Antibiotics 1
1 Antibiotics: Initial Concepts and Considerations 4
2 Major Classes of Antibiotics and Their Modes of Action 16
Section II
3
4
5
6
7
8
Mechanisms: Antibiotic Action by Bacterial Target Class 33
Assembly of the Peptidoglycan Layer of Bacterial Cell Walls 36
Antibiotics That Block Peptidoglycan Assembly and Integrity 68
Antibiotics That Disrupt Membrane Integrity 102
Antibiotics That Block Protein Synthesis 114
Antibiotics That Target DNA and RNA Information Transfer 148
Antibiotics That Block Biosynthesis of the DNA Building
Block Deoxythymidylate 164
Section III Mechanisms: Bacterial Resistance to Antibiotics 177
9 Bacterial Antibiotic Resistance: Overview 180
10 Antibiotic Resistance: Modification or Destruction of the Antibiotic 198
11 Antibiotic Resistance via Membrane Efflux Pumps 220
12 Resistance via Target Modification 230
13 Tuberculosis: A Formidable Challenge for Antibiotic Therapy 252
Viii I CONTENTS
Section IV Mechanisms: Antibiotic Biosynthesis 273
14 Antibiotic Biosynthesis: Principles 276
15 Biosynthesis of Peptide Antibiotics 288
16 Biosynthesis of Polyketide Antibiotics 320
17 Biosynthesis of Oligosaccharide, Isoprenoid, and
C-P Antibiotic Classes 344
Section V Opportunities 363
18 Underexploited Pathways and Targets for Antibiotics 366
19 Prospects for New Molecules and New Targets 398
References 421
Index 455
A chemocentric view of the molecular structures of antibiotics,
their origins, actions, and major categories of resistance
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules from
both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of
the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively
with bacterial targets,
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall
assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and
the folate pathway to deoxythymidyiate. It addresses the universe of bacterial resistance, from the concept
of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux,
and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of
natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
• What are antibiotics?
• Where do antibiotics come from?
• How do antibiotics work?
• Why do antibiotics stop working?
• How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology medicinal chemistry,
microbiology, and biochemistry. It is also a valuable reference for microbiologists, biological and natural product
chemists, pharmacologists, and research and development scientists.
|
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| discipline | Chemie / Pharmazie Biologie Medizin |
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| indexdate | 2025-02-03T17:57:29Z |
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| isbn | 9781555819309 |
| language | English |
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| publishDate | 2016 |
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| publisher | ASM Press |
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| spellingShingle | Walsh, Christopher Wencewicz, Timothy Antibiotics challenges, mechanisms, opportunities Antibiotics cabt Antibiotiques Antibióticos larpcal Micro-organismes - Résistance aux médicaments Resistência microbiana às drogas larpcal Anti-Bacterial Agents pharmacology Antibiotics Drug Resistance, Bacterial Drug resistance in microorganisms Antibiotikum (DE-588)4002257-2 gnd |
| subject_GND | (DE-588)4002257-2 |
| title | Antibiotics challenges, mechanisms, opportunities |
| title_auth | Antibiotics challenges, mechanisms, opportunities |
| title_exact_search | Antibiotics challenges, mechanisms, opportunities |
| title_full | Antibiotics challenges, mechanisms, opportunities by Christopher Walsh and Timothy Wencewicz |
| title_fullStr | Antibiotics challenges, mechanisms, opportunities by Christopher Walsh and Timothy Wencewicz |
| title_full_unstemmed | Antibiotics challenges, mechanisms, opportunities by Christopher Walsh and Timothy Wencewicz |
| title_short | Antibiotics |
| title_sort | antibiotics challenges mechanisms opportunities |
| title_sub | challenges, mechanisms, opportunities |
| topic | Antibiotics cabt Antibiotiques Antibióticos larpcal Micro-organismes - Résistance aux médicaments Resistência microbiana às drogas larpcal Anti-Bacterial Agents pharmacology Antibiotics Drug Resistance, Bacterial Drug resistance in microorganisms Antibiotikum (DE-588)4002257-2 gnd |
| topic_facet | Antibiotics Antibiotiques Antibióticos Micro-organismes - Résistance aux médicaments Resistência microbiana às drogas Anti-Bacterial Agents pharmacology Drug Resistance, Bacterial Drug resistance in microorganisms Antibiotikum |
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