Down Syndrome from understanding the neurobiology to therapy
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| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
2012
|
| Schriftenreihe: | Progress in brain research
v. 197 |
| Schlagworte: | |
| Online-Zugang: | DE-29 DE-1046 URL des Erstveröffentlichers |
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MARC
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| 264 | 1 | |a Amsterdam |b Elsevier |c 2012 | |
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| 490 | 0 | |a Progress in brain research |v v. 197 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist | ||
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.858842 |
| dewey-search | 616.858842 |
| dewey-sort | 3616.858842 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043877845 |
| illustrated | Not Illustrated |
| indexdate | 2024-12-24T05:27:12Z |
| institution | BVB |
| isbn | 9780444542991 044454299X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029287529 |
| oclc_num | 793547674 |
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| owner_facet | DE-29 DE-1046 |
| physical | vii, 262 pages |
| psigel | ZDB-33-ESD ZDB-33-EBS ZDB-33-ESD FAW_PDA_ESD |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Elsevier |
| record_format | marc |
| series2 | Progress in brain research |
| spelling | Down Syndrome from understanding the neurobiology to therapy edited by Mara Dierssen and Rafael De La Torre Amsterdam Elsevier 2012 vii, 262 pages txt rdacontent c rdamedia cr rdacarrier Progress in brain research v. 197 Includes bibliographical references and index Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Developmental neurobiology fast Down syndrome fast Down syndrome Developmental neurobiology Dierssen, Mara Sonstige oth Torre, Rafael de la Sonstige oth http://www.sciencedirect.com/science/book/9780444542991 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Down Syndrome from understanding the neurobiology to therapy Developmental neurobiology fast Down syndrome fast Down syndrome Developmental neurobiology |
| title | Down Syndrome from understanding the neurobiology to therapy |
| title_auth | Down Syndrome from understanding the neurobiology to therapy |
| title_exact_search | Down Syndrome from understanding the neurobiology to therapy |
| title_full | Down Syndrome from understanding the neurobiology to therapy edited by Mara Dierssen and Rafael De La Torre |
| title_fullStr | Down Syndrome from understanding the neurobiology to therapy edited by Mara Dierssen and Rafael De La Torre |
| title_full_unstemmed | Down Syndrome from understanding the neurobiology to therapy edited by Mara Dierssen and Rafael De La Torre |
| title_short | Down Syndrome |
| title_sort | down syndrome from understanding the neurobiology to therapy |
| title_sub | from understanding the neurobiology to therapy |
| topic | Developmental neurobiology fast Down syndrome fast Down syndrome Developmental neurobiology |
| topic_facet | Developmental neurobiology Down syndrome |
| url | http://www.sciencedirect.com/science/book/9780444542991 |
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