Cell signalling
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| Format: | Buch |
| Sprache: | English |
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Oxford
Oxford University Press
[2021]
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| Ausgabe: | Fourth edition |
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| Online-Zugang: | Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1819609598644977664 |
|---|---|
| adam_text | m CONTENTS
LIST OF FIGURES xiv
LIST OF TABLES xix
LIST OF CASE STUDIES xx
LIST OF ABBREVIATIONS xxi
1 An introduction to cellular signalling 3
1.1 Introduction 3
1.2 The main principles of cell signalling 5
1.3 Change is the key 7
1.4 What makes a good signal? 9
1 .5 Different ways in which cells signal to each other 1 1
1.6 Cell-to-cell signalling 15
1.7 Amplification and physical architectures 18
1.8 Coordination of signailing 21
1.9 Domains and modules 24
1.10 Oncogenes 29
Summary 30
What next? 30
Further reading 31
2 Pathways are the key to signalling 35
2.1 Introduction 35
2.2 Simplified examples of signaili ng pathways 38
Summary 44
What next? 44
Further reading 45
3 A look at some of the history and techniques of cell signalling 46
3.1 A brief history 46
3.2 A brief look at some techniques 51
Summary 60
What next? 61
Further reading 62
Contents
Extracellular signals: hormones, cytokines and growth factors 69
4.1 introduction 70
4.2 Hormones 71
4.3 Plant hormones 77
4.4 Cytokines 81
4.5 Growth factors 87
4.6 Neurotransmitters 89
4.7 ATP as an extracellular signal 9 0
4.8 Pheromones 91
Summary 9 3
What next? 93
Further reading 94
Detection of extracellular signals: the role of receptors 97
5.1 Introduction 98
5.2 Types of receptors 100
5.3 Ligand binding to their receptors 112
5.4 Receptor sensitivity and receptor density T7
Summary 122
What next? 123
Further reading 123
6 Protein phosphorylation, kinases and phosphatases 126
6.1 Introduction 127
6.2 Serine/threonine kinases 133
6.3 Tyrosine kinases 153
6.4 Mitogen-activated protein kinases 139
6.5 Histidine phosphorylation
6.6 Phosphatases
6.7 Other covalent modifications
6.8 Ubiquitin-proteasome system 120
Summary 123
What next? 125
Further reading 125
7 Cyclic nucleotides, cyclases and G proteins 182
7.1 Introduction 183
7.2 cAMP 183
7.3 Adenylyl cyclase 187
7.4 Adenylyl cyclase control and the role of G proteins 190
Contents XI
7.5 Other roles of the heterotrimeric G proteins
7.6 Guanylyl cyclase ‘ 7:-
7.7 Phosphodiesterases
7.8 Compartmentalization of nucleotide signalling ■
7.9 The GTPase superfamily: functions of monomeric
G proteins
Summary
What next?
Further reading
B Inositol phosphate metabolism and roles of membrane lipids
8.1 Introduction
8.2 Events at the membrane
8.3 The breakdown of the inositol phosphate lipids
8.4 Inositol 1,4,5-trisphosphate and its fate
8.5 The role of diacylglycérol
8.6 Inositol phosphate metabolism at the nucleus
8.7 Other lipids involved in signalling
8.8 Related lipid derived signalling molecules
Summary
What next?
Further reading
9 Intracellular calcium ions: control of their concentrations
and roles in signalling
9.1 Introduction
9.2 Calmodulin
9.3 The plasma membrane and its role in calcium ion
concentration maintenance
9.4 Intracellular stores
9.5 Gradients, waves and oscillations
9.6 Sphingosine-1-phosphate .
9.7 Cyclic ADP-ribose
9.8 Nicotinate adenine-dinucleotide phosphate
9.9 Fluorescence detection and confocal microscopy
Summary
What next?
Further reading
10 Reactive oxygen species, reactive nitrogen species
and redox signalling
10.1 Introduction
1 0,2 Nitric oxide
198
199
203
207
209
217
218
218
222
222
224
227
230
236
237
238
245
246
247
247
251
252
258
262
265
273
280
281
282
282
284
285
286
290
290
292
XII Contents
10.3 Reactive oxygen species: superoxide and hydrogen
peroxide 300
10.4 Interactions of ROS and RNS 307
10.5 Hydrogen sulfide 308
10.6 Redox signalling and molecular mechanisms
of hydrogen peroxide signalling 308
10.7 Measuring ROS, RNS and H2S 311
10.8 Carbon monoxide 313
Summary 313
What next? 314
Further reading 314
11 Insulin and the signal transduction cascades it invokes 321
11.1 The insulin signalling system 321
Summary 336
What next? 337
Literature link 337
Further reading 338
Perception of the environment 340
12.1 Introduction 340
12.2 Photodetection in the eye 341
12.3 Other environment perception systems 349
Summary 352
What next? 352
Literature link 353
Further reading 354
13 Signalling in development and for the regulation
of gene expression 356
13.1 Introduction 357
13.2 Transcription factors 359
13.3 Transforming growth factor (5 363
13.4 Notch receptor signalling 366
13.5 Hedgehog signalling 368
13.6 Wnt signalling 371
13.7 Toll-like receptor signalling 373
Summary 376
What next? 376
Literature link 377
Further reading 378
Contents
X III
14 Life, death and apoptosis 382
14.1 Introduction 382
14.2 An overview of apoptosis 383
14.3 Caspases 384
14.4 The intrinsic pathway 387
14.5 The extrinsic pathway 391
Summary 394
What next? 395
Literature link 395
Further reading 396
pO
15 Celi signalling: importance, complexity and the future 401
15.1 Introduction 401
15.2 Steady states, thresholds and signalling 402
15.3 Specificity, subtlety and crosstalk 403
15.4 Moonlighting proteins 404
15.5 Longer-term effects 405
15.6 Drug discovery and the future for cell signalling
manipulation 406
15.7 The future 408
Further reading 409
INDEX
411
|
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| discipline | Biologie |
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| format | Book |
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| id | DE-604.BV043832152 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T05:23:55Z |
| institution | BVB |
| isbn | 9780199658480 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029242922 |
| oclc_num | 962407726 |
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| owner_facet | DE-355 DE-BY-UBR DE-29T DE-11 |
| physical | xxix, 420 Seiten Illustrationen |
| publishDate | 2021 |
| publishDateSearch | 2021 |
| publishDateSort | 2021 |
| publisher | Oxford University Press |
| record_format | marc |
| spellingShingle | Hancock, John T. Cell signalling Signaltransduktion (DE-588)4318717-1 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| subject_GND | (DE-588)4318717-1 (DE-588)4136131-3 (DE-588)4143413-4 |
| title | Cell signalling |
| title_auth | Cell signalling |
| title_exact_search | Cell signalling |
| title_full | Cell signalling John T. Hancock |
| title_fullStr | Cell signalling John T. Hancock |
| title_full_unstemmed | Cell signalling John T. Hancock |
| title_short | Cell signalling |
| title_sort | cell signalling |
| topic | Signaltransduktion (DE-588)4318717-1 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| topic_facet | Signaltransduktion Zellkommunikation Aufsatzsammlung |
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