Cancer stem cells philosophy and therapies
"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and ph...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, Massachusetts
Harvard University Press
2016
|
| Schlagworte: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV043602962 | ||
| 003 | DE-604 | ||
| 005 | 20160704 | ||
| 007 | t| | ||
| 008 | 160615s2016 xx a||| |||| 00||| eng d | ||
| 020 | |a 9780674088740 |9 978-0-674-08874-0 | ||
| 035 | |a (OCoLC)953101787 | ||
| 035 | |a (DE-599)BVBBV043602962 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-20 | ||
| 100 | 1 | |a Laplane, Lucie |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Cancer stem cells |b philosophy and therapies |c Lucie Laplane |
| 264 | 1 | |a Cambridge, Massachusetts |b Harvard University Press |c 2016 | |
| 300 | |a X, 252 pages |b illustrations |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 505 | 8 | |a Includes bibliographical references and index | |
| 505 | 8 | |a Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? | |
| 520 | |a "An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher | ||
| 650 | 4 | |a Cancer cells | |
| 650 | 4 | |a Stem cells | |
| 650 | 4 | |a Cancer / Treatment / Philosophy | |
| 650 | 4 | |a Oncology | |
| 650 | 7 | |a Cancer cells |2 fast | |
| 650 | 7 | |a Cancer / Treatment / Philosophy |2 fast | |
| 650 | 7 | |a Oncology |2 fast | |
| 650 | 7 | |a Stem cells |2 fast | |
| 650 | 4 | |a Philosophie | |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-029017097 | |
Datensatz im Suchindex
| _version_ | 1819297153486422017 |
|---|---|
| any_adam_object | |
| author | Laplane, Lucie |
| author_facet | Laplane, Lucie |
| author_role | aut |
| author_sort | Laplane, Lucie |
| author_variant | l l ll |
| building | Verbundindex |
| bvnumber | BV043602962 |
| contents | Includes bibliographical references and index Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? |
| ctrlnum | (OCoLC)953101787 (DE-599)BVBBV043602962 |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03237nam a2200397 c 4500</leader><controlfield tag="001">BV043602962</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20160704 </controlfield><controlfield tag="007">t|</controlfield><controlfield tag="008">160615s2016 xx a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780674088740</subfield><subfield code="9">978-0-674-08874-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)953101787</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043602962</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-20</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Laplane, Lucie</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cancer stem cells</subfield><subfield code="b">philosophy and therapies</subfield><subfield code="c">Lucie Laplane</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge, Massachusetts</subfield><subfield code="b">Harvard University Press</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">X, 252 pages</subfield><subfield code="b">illustrations</subfield><subfield code="c">25 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer?</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stem cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer / Treatment / Philosophy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oncology</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cancer cells</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cancer / Treatment / Philosophy</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Oncology</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Stem cells</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Philosophie</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029017097</subfield></datafield></record></collection> |
| id | DE-604.BV043602962 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T05:09:29Z |
| institution | BVB |
| isbn | 9780674088740 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029017097 |
| oclc_num | 953101787 |
| open_access_boolean | |
| owner | DE-20 |
| owner_facet | DE-20 |
| physical | X, 252 pages illustrations 25 cm |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Harvard University Press |
| record_format | marc |
| spelling | Laplane, Lucie Verfasser aut Cancer stem cells philosophy and therapies Lucie Laplane Cambridge, Massachusetts Harvard University Press 2016 X, 252 pages illustrations 25 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? "An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher Cancer cells Stem cells Cancer / Treatment / Philosophy Oncology Cancer cells fast Cancer / Treatment / Philosophy fast Oncology fast Stem cells fast Philosophie |
| spellingShingle | Laplane, Lucie Cancer stem cells philosophy and therapies Includes bibliographical references and index Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? Cancer cells Stem cells Cancer / Treatment / Philosophy Oncology Cancer cells fast Cancer / Treatment / Philosophy fast Oncology fast Stem cells fast Philosophie |
| title | Cancer stem cells philosophy and therapies |
| title_auth | Cancer stem cells philosophy and therapies |
| title_exact_search | Cancer stem cells philosophy and therapies |
| title_full | Cancer stem cells philosophy and therapies Lucie Laplane |
| title_fullStr | Cancer stem cells philosophy and therapies Lucie Laplane |
| title_full_unstemmed | Cancer stem cells philosophy and therapies Lucie Laplane |
| title_short | Cancer stem cells |
| title_sort | cancer stem cells philosophy and therapies |
| title_sub | philosophy and therapies |
| topic | Cancer cells Stem cells Cancer / Treatment / Philosophy Oncology Cancer cells fast Cancer / Treatment / Philosophy fast Oncology fast Stem cells fast Philosophie |
| topic_facet | Cancer cells Stem cells Cancer / Treatment / Philosophy Oncology Philosophie |
| work_keys_str_mv | AT laplanelucie cancerstemcellsphilosophyandtherapies |