Molecular aspects of alcohol and nutrition
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2016
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| 245 | 1 | 0 | |a Molecular aspects of alcohol and nutrition |c edited by Vinood B. Patel (PhD Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK) |
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Datensatz im Suchindex
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| adam_text | Titel: Molecular aspects of alcohol and nutrition
Autor: Patel, Vinood B
Jahr: 2016
Table of Contents
List of Contributors
Series Preface
Preface
IX
XUl
XV
Molecular Profiling of the Effects of Ethanol Consumption
in Adolescent Rats 53
Conclusions 58
References 59
_I_
GENERAL AND INTRODUCTORY
ASPECTS
1. Nutrients and Liver Metabolism
DANIEL GYAMFI, KWABENA OWUSU DANQUAH
Introduction 3
Hepatic Carbohydrate Metabolism 3
Hepatic Fat Metabolism 7
Hepatic Amino Acid Metabolism II
Conclusions 13
References 14
2. Alcohol Metabolism: General Aspects
REEM GHAZALI, VINOOD B. PATEL
Introduction 17
Alcohol Metabolism 17
The Epigenetic Changes of Alcohol 18
Conclusions 20
References 20
II
MOLECULAR BIOLOGY OF THE CELL
3. Alcohol and Aldehyde Dehydrogenases: Molecular
Aspects
KWABENA OWUSU DANQUAH, DANIEL GYAMFI
Overview of Alcohol and Aldehyde Dehydrogenases 25
Human ALDH Superfamily 25
Modifications of ALDH and Biomedical Implications 30
Genomics of the ALDH Superfamily 31
ALDH Polymorphism in Alcohol-Related Diseases 39
Conclusions 40
References 41
4. Alcohol Intake and Apoptosis: A Review and
Examination of Molecular Mechanisms in the
Central Nervous System
MARIA D. CAMARGO, CHERRY IGNACIO, PATRICK BURKE,
FRANK A. M1DDLETON
Introduction 45
5. Pathogenic Mechanisms in Alcoholic Liver
Disease (ALD): Emerging Role of Osteopontin
JASON D. COOMBES, WING-KIN SYN
Introduction 63
General Mechanisms of ALD 63
ALD Fibrosis - Pathogenic Mechanisms 64
Role of OPN in ALD 66
Conclusions 68
References 68
6. The Role of CD36 in the Pathogenesis
of Alcohol-Related Disease
CALEB T. EPPS, ROBIN D. CLUGSTON, AMIT SAHA,
WILLIAM S. BLANER, Ll-SHIN HUANG
Introduction 71
The Structure-Function Relationship of CD36 71
CD36 and FA Uptake 73
CD36 and Ca2* Signaling 76
CD36 as a Pattern Recognition Receptor 77
CD36 in the Brain 78
Conclusions 79
References 81
7. Thiamine Deficiency and Alcoholism
Psychopathology
ANN M. MANZARDO
Introduction 85
Biochemistry of Thiamine Pyrophosphate 85
Secondary Effects of Thiamine Deficiency 87
Thiamine Deficiency, Mood and Behavior 87
Thiamine Analogs 88
Benfotiamine Trial 89
Conclusions 91
References 92
8. Vitamin B Regulation of Alcoholic
Liver Disease
CHARLES H. HALSTED, VALENTINA MEDICI
Effects of Chronic Alcoholism on the Availability
of Folate, Vitamin B12, and Vitamin B6 95
Interactions of Selected B Vitamins in Hepatic Methionine
Metabolism with Implications for Alcoholic Liver Injury 98
v
TABLE OF CONTENTS
vi
Effects of Chronic Alcohol Exposure
on Methionine Metabolic Pathways 99
Epidemiology and Pathogenesis of Alcoholic Liver Disease 99
Regulatory Effects of Altered Reactions in Methionine
Metabolism and its Metabolites on Mechanisms
of Alcoholic Liver Disease 100
The Ethanol-Fed Micropig Model for the Interaction
of Ethanol with Methionine Metabolism, and Induction of
Alcoholic Liver Disease 101
Effects of SAM in Clinical Trials of Treatment of ALD 101
Relationships of Altered Methionine Metabolism
to Epigenetic Regulation of Gene Expression
in Alcoholic Liver Injury 102
Conclusion 103
References 103
9. Interactions Vitamin D - Bone Changes in
Alcoholics
EMILIO GONZALEZ-REIMERS, FRANCISCO
santolaria-fernAndez, GERALDINE QUINTERO-PLATT,
ANTONIO MARTINEZ-RIERA
Introduction 107
Vitamin D Metabolism 107
Vitamin D Among Alcoholics 108
Vitamin D Deficiency and Bone Metabolism 109
Effec ts of Therapy 114
Conclusion 114
References 115
10. Antioxidant Treatment of Alcoholism
CAMILA S. SILVA, GUILHERME V. PORTARI, HELIO VANNUCCHI
Importance of the Antioxidant Systems to the Organism 119
Antioxidant Status in Alcoholism 120
Antioxidant Treatment of Alcoholism 121
Conclusions 125
References 128
11. Selenium Dietary Supplementation
and Oxidative Balance in Alcoholism
OLIMPIA CARRERAS, MARIA LUISA OJEDA, FATIMA NOGALES
Introduction 133
Alcohol and Malnutrition: Selenium Supplementation 134
Alcohol and Selenium Tissue Distribution: Selenium
Supplementation 135
Alcohol and Oxidative Balance: Selenium Supplementation 137
Conclusion 139
References 139
12. Role of Zinc in Alcoholic Liver Disease
WEI ZHONG, Q1AN SUN, ZHANXIANG ZHOU
Introduction 143
Zinc Metabolism and Function 143
Occurrence of Zinc Deficiency in ALD 144
Mechanisms of Zinc Dyshomeostasis in ALD 145
Beneficial Effects of Zinc on ALD 147
Molecular Mechanisms of Zinc Protection Against ALD 149
Zinc Supplementation in Human ALD 151
Conclusions 152
References 152
13. Interactions Between Alcohol and Folate
BOGDAN CYLW1K, LECH CHROSTEK, EWA GRUSZEWSKA
Introduction 157
Conclusions 166
References 167
14. Effects of Acetaldehyde on Intestinal Barrier
Function
ELHASEEN E. ELAMIN, AD A. MASCLEE, DAISY M. JONKERS
Introduction 171
The Intestinal Epithelial Barrier and Apical Junctional
Complex 171
Generation and Metabolism of Acetaldehyde
in the Gastrointestinal Tract 172
Role of Intestinal Microbiota in Production
and Metabolism of Acetaldehyde 175
Effects of Acetaldehyde on Intestinal Barrier
Epithelial Integrity 175
Mechanisms of Acetaldehyde-Induced Intestinal Barrier
Dysfunction 177
Modulation of Acetaldehyde-Induced Intestinal
Epithelial Barrier Function 178
Conclusions 180
References 181
15. Cholesterol Regulation by Leptin in Alcoholic
Liver Disease
BAL ASUBRAM AN IY AN VAIRAPPAN
Introduction 187
Alcohol Metabolism 187
Effects of Alcohol on Lipid Metabolism 187
Triglycerides 188
Fatty Acids 189
Hepatic Lipid Metabolism is Controlled by Several Master
Transcription Factors 189
Cholesterol 191
Obesity, Leptin, and ALD 192
Conclusions 196
References 197
16. The Corticotropin Releasing Factor System and
Alcohol Consumption
ANDREY E. RYABININ, WILLIAM J. G1ARDINO
Introduction: Alcohol and the Brain 201
CRF, Urocortins, and the HPA-Axis 201
Function of CRF System Components Revealed
by Genetic Knockouts 202
Effects of EtOH on the HPA-Axis 203
Effects of EtOH on the Extrahypothalamic CRF System 203
Effects of CRF Receptors on EtOH Drinking 204
TABLE OF CONTENTS vii
Ucnl and EtOH Drinking 205 Candidate Gene Studies 248
Interactions of CRF System, Stress, EtOH Drinking Genome-Wide Association Study 253
and Dependence 206 Limitations 254
Conclusions 206 Conclusions 254
References 207 References 255
17. Metabolic Profiling Approaches for Biomarkers
of Ethanol Intake
H.G. GIKA, I.D. WILSON
Introduction 213
Metabolic Profiling 213
Analytical Technologies for Global Metabolic Profiling 213
Ethanol Exposure Studies on Animal Models 215
Ethanol Exposure Studies in Man 219
Conclusions 220
References 221
21. Alcohol and Epigenetic Modulations
CLAUDIO D ADDARIO, MAURO MACCARRONE
Introduction 261
Epigenetics 262
Alcohol Effects on Epigenetic Mechanisms 264
Alcohol Metabolism Influences Nutritional Status via
Epigenetic Mechanisms 268
Future Directions 269
Conclusions 270
References 270
_m_
GENETIC MACHINERY AND ITS
FUNCTION
18. Gene Expression in Alcoholism: An Overview
REEM GHAZALI, VINOOD B. PATEL
Introduction 225
Brain Serotonin and Alcoholism 225
NMDA Receptor and Alcoholism 226
Fetal Alcohol Syndrome 226
Sweet Preference and Alcohol Dependence 226
Stem Cell Therapy and Alcoholism 227
Genetic Risks of Alcoholism 227
MicroRNA and Alcoholism 227
Conclusions 228
References 228
19. Cytochrome P4502E1 Gene Polymorphisms and
the Risks of Ethanol-Induced Health Problems
in Alcoholics
TAO ZENG, KE-QIN XIE
The Polymorphisms of CYP2E1 Gene
and the Nomenclatures of CYP2E1 Alleles 231
The Polymorphisms of CYP2E1 Gene and Individual
Susceptibility to Alcohol Dependence (AD) 233
CYP2EI Gene Polymorphisms and Susceptibility
to Alcoholic Liver Disease (ALD) 235
CYP2EI Gene Polymorphism and Risks
of Alcoholic Pancreatitis (AP) 239
Conclusions 242
References 243
20. Genes Associated with Alcohol Withdrawal
KESHENG WANG, LIANG WANG
22. The miRNA and Extracellular Vesicles
in Alcoholic Liver Disease
FATEMEH MOMEN-HERAVI, SHASHI BALA
Introduction 275
Extracellular Vesicle-Associated miRNAs as Potential
Biomarkers for ALD 278
miRNA-Targeted Therapies for ALD 281
Conclusions 284
References 285
23. Alcohol Metabolism and Epigenetic Methylation
and Acetylation
MARISOL RESENDIZ, SHERRY CHIAO-LING LO, JILL K. BADIN,
YA-JEN CHIU, FENG C. ZHOU
Introduction 287
Alcohol Metabolism and Epigenetic Acetylation 288
Alcohol and Methyl Metabolism 289
Alcohol Affects the Epigenetics Converting Enzymes 295
Epigenetic Footprint of Alcohol Induced Dysfunction
and Disease 296
Treatment and Biomarkers of Alcohol Diseases Through
Epigenetic Pathway 299
Conclusions 299
References 301
24- Molecular Mechanisms of Alcohol-Associated
Carcinogenesis
HELMUT K. SEITZ, SEBASTIAN MUELLER
Introduction 305
Effect of Ethanol on DNA 306
Effect of Ethanol on Epigenetics 308
Alcohol, Retinoids, and Cancer 309
The Role of Estrogens in Ethanol
Mediated Breast Cancer 310
Summary and Conclusions 311
References 312
Introduction
247
viii
TABLE OF CONTENTS
25. Molecular Link Between Alcohol and Breast
Cancer: the Role of Salsolinol
MARIKO MURATA, KAORU MIDORIKAWA, SHOSUKE
KAWANISHI
Introduction 315
Salsolinol Derived from Alcohol, as a Novel Causative
Substance of Breast Cancer 315
DNA Damage Capability of Salsolinol 316
Proposed Mechanisms of Oxidative DNA Damage Induced
by Salsolinol 318
Cell Proliferating Ability of Salsolinol 320
Conclusion 321
References 322
26. Ethanol Impairs Phospholipase
D Signaling in Astrocytes
UTE BURKHARDT, JOCHEN KLEIN
Astrocytes 325
Phospholipase D 325
Transphosphatidylation 325
Isoforms of Phospholipase D 326
Regulation of Phospholipase D 326
Functions of Phospholipase D 328
Interruption of the PLD Signaling Pathway by Ethanol 329
Conclusions 332
Summary 333
References 334
27. Metabolic Changes in Alcohol Gonadotoxicity
GANNA M. SHAYAKHMETOVA, LARYSA B. BONDARENKO
Introduction 337
Metabolic Changes in Males Alcohol Gonadotoxicity 339
Metabolic Changes in Females Alcohol Gonadotoxicity 346
Conclusions 350
References 351
28. Molecular Effects of Alcohol on Iron
Metabolism
KOSHA MEHTA, SEBASTIEN FARNAUD, VINOOD B. PATEL
Introduction 355
Overview of Iron Metabolism 355
Alcohol and Iron: Clinical Observations
and Molecular Events 360
Exploring the Iron-Alcohol Link for Diagnosis
and Therapeutics 362
Conclusions 365
References 365
Index 369
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| title | Molecular aspects of alcohol and nutrition |
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| title_exact_search | Molecular aspects of alcohol and nutrition |
| title_full | Molecular aspects of alcohol and nutrition edited by Vinood B. Patel (PhD Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK) |
| title_fullStr | Molecular aspects of alcohol and nutrition edited by Vinood B. Patel (PhD Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK) |
| title_full_unstemmed | Molecular aspects of alcohol and nutrition edited by Vinood B. Patel (PhD Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK) |
| title_short | Molecular aspects of alcohol and nutrition |
| title_sort | molecular aspects of alcohol and nutrition |
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