Biomedical applications and toxicology of carbon nanomaterials
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| 245 | 1 | 0 | |a Biomedical applications and toxicology of carbon nanomaterials |c edited by Chunying Chen, Haifand Wang |
| 264 | 1 | |a Weinheim |b Wiley-VCH Verlag GmbH & Co. KGaA |c [2016] | |
| 264 | 4 | |c © 2016 | |
| 300 | |a XXVI, 543 Seiten |b Illustrationen, Diagramme (teilweise farbig) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Nanostrukturiertes Material |0 (DE-588)4342626-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nanomedizin |0 (DE-588)1067838503 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Kohlenstoffverbindungen |0 (DE-588)4164566-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Toxikologie |0 (DE-588)4060538-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Kohlenstoffverbindungen |0 (DE-588)4164566-2 |D s |
| 689 | 0 | 1 | |a Nanostrukturiertes Material |0 (DE-588)4342626-8 |D s |
| 689 | 0 | 2 | |a Nanomedizin |0 (DE-588)1067838503 |D s |
| 689 | 0 | 3 | |a Toxikologie |0 (DE-588)4060538-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Chen, Chunying |0 (DE-588)1025134648 |4 edt | |
| 700 | 1 | |a Wang, Haifang |0 (DE-588)1103031546 |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-3-527-69287-3 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, MOBI |z 978-3-527-69288-0 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-69285-9 |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028709343&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028709343 | ||
Datensatz im Suchindex
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| adam_text | CONTENTS
UST OF CONTRIBUTORS X IX
PREFACE X X V
1 SYNTHESIS, FUNCTIONALIZATION, AND CHARACTERIZATION 1
JIANXUN XU, XING LU
*
AND BAOWEN LI
1.1 IN TRO D U CTIO N 1
1.2 FULLERENES AND M ETALLOFULLERENES 1
1.2.1 SYNTHESIS AND P URIFICATION 2
1.2.1.1 SYNTHESIS 2
1.2.1.2 P URIFICATION 2
1.2.2 CHEMICAL FUNCTIONALIZATION 3
1.2.2.1 CARBENE REACTION 3
1.2.2.2 B IN G E L-H IRS C H REACTION 4
1.2.2.3 PRATO REACTION 5
1.2.2.4 BIS*SILYLATION 5
1.2.2.5 D IE LS -A LD E R REACTION AND BENZYNE REACTION 5
1.2.2.6 SINGLY BONDED A D D ITIO N 6
1.2.2.7 SUPRAMOLECULAR COMPLEXES O F EMFS 6
1.2.3 CHARACTERIZATION 6
1.2.3.1 SYNCHROTRON RADIATION POWDER D IFF^
(SRPD)/RIETVELD/M EM 6
1.2.3.2 NUCLEAR M AGNETIC RESONANCE (NM R) SPECTROSCOPY 7
1.2.3.3 THEORETICAL CALCULATION 7
1.2.3.4 SINGLE*CRYSTAL X *RAY D IFFRACTION CRYSTALLOGRAPHY 7
1.2.3.5 OTHERS 8
1.2.4 QUESTIONS AND FUTURE D IRECTIONS 8
1.3 CARBON NANOTUBES 8
1.3.1 SYNTHESIS 9
1.3.1.1 A RC DISCHARGE M ETHOD 9
1.3.1.2 LASER A BLATION M ETHOD
10
1.3.1.3 C VD M ETHOD 10
1.3.1.4 SYNTHESIS O F CNTS W ITH A DEFINED STRUCTURE 10
1.3.2 FUNCTIONALIZATION 11
2
.
2.1
2
.
2.2
2.23
994
9 941
9949
2.2.5
2.2.5.1
2.2.5.2
2.2.53
2
.
2.6
2.2.7
2
.
2.8
2.3
*DENTIFICATION AND DETECTION OF CARBON NANOMATERIALS IN BIOLOGICAL
SYSTEMS 29
HAIFANG WANG, ZHENG-MEISONG, YI-FAN YANG, AORIENG CAO, AND YUANFANG LIU
IN TRO D U CTIO N 29
AVAILABLE TECHNIQUES FOR Q UALITATIVE AND Q UANTITATIVE
D ETERM INATION 30
O PTICAL M ICROSCOPIC OBSERVATION 30
ELECTRON M ICROSCOPIC (EM) OBSERVATION 31
RAMAN SPECTROSCOPIC MEASUREMENT 33
FLUORESCENCE ANALYSIS 36
IN TRIN SIC FLUORESCENCE ANALYSIS 36
LABELED FLUORESCENCE ANALYSIS 39
ISOTOPE LABELING M ETHOD 39
RADIOISOTOPE LABELING 40
STABLE ISOTOPE LABELING 43
TIPS FOR ISOTOPIC LABELING 43
CHROMATOGRAPHIC TECHNIQUE 45
FLOW C YTOM ETRY M ETHOD 45
O THER METHODS 46
SUMMARY AND O UTLOOK 47
ACKNOWLEDGMENTS 48
REFERENCES 48
3 BIODISTRIBUTION AND PHARMACOKINETICS OF CARBON NANOMATERIALS
* VIVO SS
SHENG-*** YANG,XIAOYANG LIU, ANDJINGRUXIE
3.1 IN TRO D U CTIO N 55
3.2 AM ORPHOUS CARBON NANOPARTICLES 55
3.2.1 U LTRAFINE CARBON PARTICLES
56
3.2.2 CARBON NANOPARTICLES 58
3.2.3 CARBON DOTS 59
3.3 SP2 CARBON NANOMATERIALS 62
1.3.2.1 COVALENT CHEMICAL REACTIONS 11
1.3.2.2 NONCOVALENT M ODIFICATIONS 11
1.3.3 CHARACTERIZATION 12
1.3.3.1 M ICROSCOPIC CHARACTERIZATIONS 12
1.3.3.2 SPECTROSCOPIC CHARACTERIZATIONS 13
1.3.4 QUESTIONS AND FUTURE D IRECTIONS 13
1.4 GRAPHENE 14
1.4.1 SYNTHESIS AND CHARACTERIZATION 14
1.4.2 FUNCTIONALIZATION OT BRAPHENE AND GRAPHENE OXIDE 17
1.4.3 PROSPECTS AND CHALLENGES 18
1.5 SUMMARY AND O UTLOOK 20
REFERENCES 21
1
2
2
2
2
3.3.1
3.3.2
3.3.3
3.3.4
3.3.5
3.4
3.5
4
41
4.2
4.2.1
49.11
49 19
499
4991
49 9 9
4.2.2.3
49 94
4.3
4 ^ 1
4.3.2
4.3.3
4.3.4
4.3.5
4.4
5
5.1
5.2
5.2.1
5.2.2
5.2.3
5.2.4
5.3
5.3.1
5.3.1.1
FULLERENE 62
CARBON NANOTUBES 69
CARBON NANOHORNS 77
GRAPHENE
80
GRAPHENE Q UANTUM DOTS 85
NANODIAMONDS 87
SUMMARY AND O UTLOOK 89
ACKNOWLEDGMENTS 90
REFERENCES 90
INTERACTION OF CARBON NANOMATERIALS AND COMPONENTS *N BIOLOGICAL
SYSTEMS 97
JIANTIAN AND CUICUI GE
IN TRO D U CTIO N 97
FACTORS A FFECTING INTERACTION 99
CHARACTERISTICS O F CARBON NANOMATERIALS 99
SIZE AND LAYER 99
SURFACE M ODIFICATION AND FUNCTIONALIZATION 100
BIOLOGICAL M ICROENVIRONM ENT 102
P H
103
IONIC STRENGTH 104
WEAK INTERACTIONS 104
CELL SELECTIVITY 105
INTERACTION O F CARBON NANOMATERIALS W ITH VARIOUS COMPONENTS IN
BIOLOGICAL SYSTEMS 107
CHARACTERIZATION AND M ETHODOLOGY O F INTERACTION O F CARBON
NANOMATERIALS W ITH COMPONENTS IN THE BIOLOGICAL SYSTEM 107
CARBON N ANOM ATERIAL-P HOSPHOLIPID INTERACTION 108
CARBON N A N OM ATERIAL-P ROTEIN INTERACTION 111
CARBON N A N O M A TE RIA L-D N A INTERACTION 115
CARBON N A N O M A TE RIA L-C E LL INTERACTION 119
CONCLUSION AND PERSPECTIVES 120
REFERENCES 122
BIOMEDICAL APPLICATIONS OF CARBON NANOMATERIALS 131
LIANGZHU FENG ANDZHUANG LIU
IN TRO D U CTIO N 131
BIOMEDICAL APPLICATIONS O F FULLERENES 132
FULLERENES AS A NTIOXIDANTS AND NEUROPROTECTIVE AGENTS 132
FULLERENES AS A N TITU M O R AGENTS 134
M ETALLOFULLERENES AS M R I CONTRAST AGENT 136
FULLERENES FO R O THER APPLICATIONS 136
BIOMEDICAL APPLICATIONS O F CARBON NANOTUBES 137
CARBON NANOTUBES FOR DRUG D ELIVERY 138
CARBON NANOTUBES FOR THE DELIVERY O F SMALL D RUG MOLECULES 139
5.3.1.2
5.3.2
5.3.2.1
5.3.2.2
5.3.3
5.3.3.1
5.3.3.2
5.3.3.3
5.3.3.4
5.3.4
5.4
5.4.1
5.4.1.1
5.4.1.2
5.4.2
5.4.3
5.4.4
5.5
6
6.1
6.2
6
.
2.1
6
.
2.2
6.2.3
6.2.4
6.2.5
6.3
6.3.1
6.3.2
6.3.3
6.4
6.4.1
6.4.2
6.4.3
6.4.4
6.4.5
CARBON NANOTUBES FOR THE D ELIVERY OR BIOMACROMOLECULES 141
CARBON NANOTUBES FO R PHOTOTHERMAL AND COMBINED THERAPIES O F
TUMORS 142
CARBON NANOTUBES FO R PHOTOTHERMAL THERAPY O F TUMORS 142
CARBON NANOTUBES FOR COMBINED ^ E RA P IE S O F TUMORS 143
CARBON NANOTUBES FO R BIOIMAGING 144
CARBON NANOTUBES FO R FLUORESCENCE IM A G N G 144
CARBON NANOTUBES FO R RAMAN IMAGING 145
CARBON NANOTUBES FO R PHOTOACOUSTIC IMAGING 145
CARBON NANOTUBES FOR O THER BIOIMAGING M ODALITIES 145
CARBON NANOTUBES FO R O THER BIOMEDICAL APPLICATIONS 146
BIOMEDICAL APPLICATIONS O F GRAPHENE 146
GRAPHENE FO R D RUG D ELIVERY 147
GRAPHENE FOR THE D ELIVERY O F SMALL D RUG MOLECULES 148
GRAPHENE FO R THE D ELIVERY O F BIOMACROMOLECULES 148
GRAPHENE FO R PHOTOTHERMAL AND C OM BINED T E RA P IE S O F
TUMORS 151
GRAPHENE FO R BIOIMAGING 152
GRAPHENE FO R O THER BIOMEDICAL APPLICATIONS 153
CONCLUSION AND PERSPECTIVES 153
ACKNOWLEDGMENTS 154
REFERENCES 155
PULMONARY EFFECTS OF CARBON NANOMATERIALS 163
LIYING WANG, DONNO
C.
DAVIDSON, VINCENT CASTRANOVA, AND YON ROJANASAKUL
IN TRO D U CTIO N 163
PHYSICOCHEMICAL PROPERTIES O F CARBON NANOMATERIALS 164
TYPES O F CARBON NANOMATERIALS 165
EFFECTS O F SIZE 165
EFFECTS O F AGGLOM ERATION STATE 166
ASPECT RATIO CONSIDERATIONS 168
SURFACE M ODIFICATIONS 168
FATE O F PULM ONARY EXPOSED CARBON NANOPARTICLES (DEPOSITION,
D ISTRIBUTION, TRANSLOCATION, AND CLEARANCE) 169
D EPOSITION AND D ISTRIB U TIO N O F CARBON NANOPARTICLES IN THE
LUNG 169
TRANSLOCATION O F CARBON NANOPARTICLES 172
CLEARANCE O F CARBON NANOMATERIALS FRO M THE LUNGS 175
CARBON N A N OM ATERIAL-INDUCED LUNG RESPONSES 176
KEY/SPECIFIC TARGET LUNG CELL TYPES O F PULMONARY-EXPOSED CARBON
NANOPARTICLES 176
L U N G IN FLA M M A TIO N 178
IM M UNE RESPONSE 179
FIBROSIS 180
G ENOTOXICITY 181
6.4.6
6.4.7
6.5
*
7.1
7.2
7.2.1
7.2.1.1
7.2.1.2
7.2.1.3
7.2.1.4
7.2.2
7.3
7.3.1
7.3.2
7.4
7.5
*
8.1
8.2
8
.
2.1
8
.
2.2
8.3
8.3.1
8.3.2
8.4
9
9.1
* 9
CONTENTS
*
XI
CANCER 182
CARDIOVASCULAR EFFECTS FOLLOWING PULM ONARY EXPOSURE O F CARBON
NANOMATERIALS
184
SUMMARY 184
DISCLAIMER 184
REFERENCES *8 9
CARDIOVASCULAR AND HEMOSTATIC EFFECTS OF CARBON NANOMATERIALS 195
XIOOYONG DENG, CHENG LI, JIOJUN WANG, AND PAN CHEN
BACKGROUND 195
CARBON NANOTUBES 195
H E M O TO X IC ITY O FC N T S 196
W HAT IS H EM OTOXICITY 196
COMPLEM ENT SYSTEM 197
RED BLOOD CELLS 199
HEMOSTATIC SYSTEM AND C OAGULATION/THROM BOSIS/ATHEROM A 200
EFFECTS ON CARDIOVASCULAR SYSTEM 201
FULLERENES 203
FULLERENES, ESCAPE FROM LUNGS INTO C IRCULATION 203
TOXICITY O F FULLERENES ON THE CARDIOVASCULAR SYSTEM 204
GRAPHENE-RELATED NANOMATERIALS 205
CONCLUSIONS AND O UTLOOK 208
ACKNOWLEDGMENTS 208
REFERENCES 208
MODULATION OF THE IMMUNE SYSTEM BY FULLERENE AND GRAPHENE
DERIVATIVES 213
LIGENG XU AND CHUNYING CHEN
IN TRO D U CTIO N 213
THE IM M UNOLOGICAL EFFECTS O F FULLERENE AND ITS DERIVATIVES 213
FULLERENE DERIVATIVES CAN IN H IB IT INFLAM M ATION VIA BLOCKING ROS
GENERATION 213
FULLERENE DERIVATIVES PROMOTE IM M UNE RESPONSES VIA M ODULATING
MACROPHAGES AND/OR A NTIGEN PRESENTING CELLS (APCS) 215
IM M UNOLOGICAL EFFECTS O F GRAPHENE AND ITS DERIVATIVES 222
IM M UNOLOGICAL EFFECT O F PRISTINE GRAPHENE 225
IM M UNOLOGICAL EFFECTS O F GRAPHENE OXIDE AND ITS DERIVATIVES 227
PERSPECTIVES AND O UTLOOK 231
REFERENCES 234
NEURO, HEPATO*, AND NEPHROTOXICITY OF CARBON-BASED
NANOMATERIALS 239
JIA YAO AND YONGBIN ZHANG
CARBON-BASED NANOMATERIALS: IN TRO D U CTIO N 239
N EUROTOXICITY O F CARBON-BASED NANOMATERIALS 240
9.2.1 B LO O D -B RA IN BARRIER AND BBB PENETRATION BY CARBON-BASED
NANOMATERIALS 240
9.2.2 N EUROTOXICITY O F CARBON NANOTUBES 241
9.2.3 STRATEGIES TO REDUCE N EUROTOXICITY O F CARBON NANOTUBES 243
9.2.4 N EUROTOXICITY O F OTHER CARBON-BASED NANOMATERIALS 244
9.3 HEPATO AND N EPHROTOXICITY
0
*
CARBON-BASED NANOMATERIALS 245
9.3.1 CARBON NANOTUBE B IODISTRIBUTION IN THE LIVER AND KIDNEY 245
9.3.2 B IODISTRIBUTION O F OTHER CARBON NANOMATERIALS 248
9.3.3 HEPATOTOXICITY O F CARBON NANOTUBES 2*
9.3.4 CARBON NANOTUBE NEPHROTOXICITY/R ENAL TOXICITY 254
9.3.5 H EPATOTOXICITY AND N EPHROTOXICITY O F OTHER TYPES O F
CARBON-BASED
NANOM ATERIALS 254
9.4 POINTS O F CONSIDERATION FOR TOXICITY EVALUATION O F CARBON-BASED
NANOMATERIALS 257
9.5 SUMMARY 259
ACKNOWLEDGMENTS 259
REFERENCES 259
* 0 GENOTOXICITY AND CARCINOGENIC POTENTIAL OF CARBON
NANOMATERIALS 267
TODDA. STUECKLE, LINDA SARGENT, YON ROJANASAKUL, AND LIYING WANG
10.1 IN TRO D U CTIO N 267
10.1.1 ENGINEERED NANOMATERIALS AND LONG-TERM DISEASE RISK; A N
IN TRO D U CTIO N *
10.1.2 CARCINOGENESIS: A M ULTISTEP PROCESS 270
10.1.2.1 G ENOTOXICITY AND IN ITIA TIO N 271
10.1.2.2 P ROM OTION 272
10.1.2.3 PROGRESSION 274
10.1.3 C URRENT KNOWLEDGE AND CHALLENGES IN CARCINOGENESIS STUDIES 274
10.2 CARBON NANOMATERIALS: G ENOTOXICITY AND CARCINOGENIC
POTENTIAL 275
10.2.1 PHYSICOCHEMICAL PROPERTIES O F ECNM S 275
10.2.2 U LTRAFINE CARBON BLACK 276
10.2.2.1
*
W O STUDIES 277
10.2.2.2 IN VITRO STUDIES 278
10.2.3 CARBON NANOTUBES 278
10.2.3.1 IN VIVO STUDIES 279
10.2.3.2 IN VITRO STUDIES 291
10.2.4 FULLERENES AND DERIVATIVES 296
10.2.4.1 IN VIVO STUDIES 297
10.2.4.2 IN
V ITRO
STUDIES 299
10.2.5 GRAPHENE AND GRAPHENE OXIDE 300
10.2.5.1 IN VIVO STUDIES 302
10.2.5.2 IN VITRO STUDIES 304
10.2.6 CARBON NANOFIBERS AND O THER PARTICLES 307
10
.
2
.
6.1
10
.
2
.
6.2
10.3
10.3.1
10.3.2
10.3.3
10.3.4
10.3.5
10.4
10.4.1
10.4.2
10.5
11
11.1
11.2
11.2.1
11
.
2.2
11.2.3
11.3
11.3.1
11.3.2
11.3.3
11.34
11.3.5
11.4
12
12.1
12.2
12
.
2.1
IN VIVO STUDIES 307
IN VITRO STUDIES 308
FUTURE CHALLENGES IN CARBON NANOMATERIAL CARCINOGENESIS RISK
ASSESSMENT 308
EXPOSURE CHARACTERIZATION AND FATE 308
D OSIM ETRY 309
M ODEL CHOICE 310
SYSTEMATIC EVALUATION O F GENOTOXICITY 311
ROLE O F ROS AND INFLAM M ATION 311
ASSESSMENT O F EC N M -INDUCED G ENOTOXICITY AND
CARCINOGENESIS 312
RECOMMENDATIONS FO R SCREENING ENM S FO R CARCINOGENIC
POTENTIAL 312
SYSTEMATIC SCREENING PARADIGM AND W ORKFLOW FO R E N M
CARCINOGENICITY RISK ASSESSMENT 314
CONCLUDING REMARKS 316
ACKNOWLEDGMENTS 316
DISCLAIM ER 316
REFERENCES 317
EFFECT ON REPRODUCTIVE SYSTEM OF CARBON NANOMATERIALS 333
YMG LIU AND CHUNYING CHEN
IN TRO D U CTIO N 333
EFFECTS O F CARBON NANOMATERIALS ON THE REPRODUCTIVE SYSTEM 334
CARBON NANOTUBES 335
FULLERENE DERIVATIVES 340
CARBON BLACK NANOPARTICLES 340
INSIGHTS INTO THE M OLECULAR MECHANISMS 342
POTENTIAL TOXICITY TO THE FEMALE REPRODUCTIVE SYSTEM 342
POTENTIAL TOXICITY TO MALE REPRODUCTION O F CARBON
NANOMATERIALS 343
POTENTIAL TOXICITY TO O FFSPRING O F CARBON NANOMATERIALS 345
IM PACT ON THE ENDOCRINE ORGANS AND H ORM ONE
BIOSYNTHESIS/METABOLISM 346
OTHERS 348
CONCLUSION AND PERSPECTIVES 348
ACKNOWLEDGMENTS 352
REFERENCES 352
IMMUNOLOGICAL RESPONSES INDUCED BY CARBON NANOTUBES EXPOSED TO
SKIN AND GASTRIC AND INTESTINAL SYSTEM 357
HALYAN XU, JIE IN G , QIANG I , AND XIAOJIN UE
IN TRO D U CTIO N 357
BIOLOGICAL EFFECTS O F CNTS BY DERM AL EXPOSURE 358
IN VITRO ASSESSMENT IN DERMAL-RELATED CELL LINES 358
12.2.2 IN VIVO STUDIES ON THE RESPONSES ELICITED BY SKIN EXPOSED W ITH
CNTS 361
12.3 IM M UNOLOGICAL REACTIONS ELICITED BY SUBCUTANEOUS A DM INISTRATION
O FM W C N T S 362
12.3.1 PREPARATION AND CHARACTERIZATION O F M ULTIW ALLED CARBON
NANOTUBES
FO R USES IN STUDIES 362
12.3.2 D ISTRIB U TIO N O F SUBCUTANEOUSLY INJECTED CARBON NANOTUBES 363
12.3.3 IM M UNOLOGICAL RESPONSES INDUCED BY SUBCUTANEOUSLY INJECTED
M W C N T S 369
12.3.3.1 MACROPHAGES RESPONSES EXERTED BY M W C N T S 370
12.3.3.2 M W C N T S A TTRA CT NAIVE M ONOCYTE MACROPHAGES THROUGH
A CTIVATING MACROPHAGES IN THE SUBCUTIS 373
12.3.3.3 SUBCUTANEOUSLY INJECTED M W C N T S INDUCE COMPLEMENT
A CTIVATION 375
12.3.3.4 SUBCUTANEOUSLY INJECTED M W C N T S ELEVATE PRO-INFLAM M ATORY
CYTOKINES IN THE BLOOD 376
12.4 IM M UNOLOGICAL RESPONSES INDUCED BY SUBCUTANEOUS A DM INISTRATION
O F M W C N T S IN TUM OR BEARING M ICE 377
12.4.1 M W C N T S INDUCE SYSTEMATIC IM M UNE RESPONSES IN T UM ORB
EARING
M ICE 378
12.4.2 M W C N T S UPREGULATE M U LTIP LE PRO-INFLAM M ATORY CYTOKINES
IN THE
B L O O D S
12.4.3 M W C M T S MEDIATE C YTOTOXICITY O F LYMPHOCYTES 379
12.4.4 M W C N T S INDUCE COMPLEM ENT A CTIVATION 380
12.4.5 M W C N T S A TTRA CT MONOCYTE-MACROPHAGES TO A FFECT THE
M ICROENVIRONM ENT O F TUM OR MASS 380
12.5 CNTS AS ANTIGEN DELIVERY SYSTEM TO E N H *
AGAINST TUMORS 383
12.6 IM M UNOLOGICAL RESPONSES O F GASTRIC AND INTESTINAL SYSTEMS
EXPOSED
TO CARBON NANOTUBES 386
REFERENCES 389
13 MODULATION OF IMMUNE SYSTEM BY CARBON NANOTUBES 397
MARIT LIVES AND HARRI ALENIUS
13.1 IM M UNE SYSTEM 397
13.1.1 INNATE IM M U N ITY CELLS A N D L E I R M AIN FUNCTIONS 398
13.1.2 ADAPTIVE IM M U N ITY CELLS AND ^ E I R M AIN FUNCTIONS 399
13.2 CARBON NANOTUBES (CNTS) AND INNATE IM M U N ITY 400
13.2.1 COMPLEM ENT A CTIVATION 401
13.2.2 MACROPHAGES 402
13.2.3 A CTIVATION O F INFLAMMASOME COMPLEX AND IL *LSS SECRETION 405
13.2.4 N EUTROPHILS 406
13.2.5 INNATE LYM PHOID CELLS (ILCS) 408
13.2.6 D ENDRITIC CELLS 408
13.3 CNTS AND ADAPTIVE IM M U N ITY 409
13.3.1 THE EFFECTS O FC N T S ON VACCINE DELIVERY AND IM M UNOTHERAPY
409
13.3.2 U TILIZA TIO N O F C N T SCAFFOLDS IN THE EXPANDING AND M
ODULATION O F
IM M UNE CELLS 411
13.3.3 IMMUNOSUPPRESSIVE EFFECTS O F CNTS 413
13.4 THE EFFECT O F CNTS IN A LLERGY AND ASTHM A 414
13.4.1 A LLERGIC REACTIONS AND * E I R IM M UNOLOGICAL MECHANISMS 414
13.4.2 ASTHM A 415
13.4.3 A LLERGIC PULM ONARY INFLAM M ATION INDUCED BY A IRW AY EXPOSURE
TO
CNTS 417
13.4.4 M ODULATION O F ALLERGEN-INDUCED A IRW AY INFLAM M ATION BY
EXPOSURE
TO CNTS 418
13.4.5 C N T IN THE CONTEXT O F MAST CELLS AND EOSINOPHILS 420
13.4.6 ROLE O F IL-33 PATHWAY IN C N T-INDUCED A LLERGIC RESPONSES 420
13.5 CONCLUSIONS AND FUTURE PROSPECTS 422
REFERENCES 49.4
4 * CARBON DOTS: SYNTHESIS, BIOIMAGING
*
AND BIOSAFETY ASSESSMENT 429
JIE WANG AND YOO HE
14.1 IN TRO D U CTIO N 429
14.1.1 SYNTHESIS AND FABRICATION O F C-D O TS 429
14.1.2 BIOIMAGING O F C*D
0
TS 431
14.1.3 BIOSAFETY ASSESSMENT O F C*DOTS 432
14.2 SYNTHETIC STRATEGIES 433
14.2.1 MICROWAVE-ASSISTED METHODS 433
14.2.2 H YDROTHERM AL CARBONIZATION 434
14.2.3 ELECTROCHEMICAL SYNTHESIS 437
14.2.4 CHEMICAL O XIDATION 439
14.2.5 U LTROSONICATION 442
14.2.6 PLASMA TREATM ENT 444
14.2.7 LASER A BLATION METHODS 445
14.2.8 SUPPORTED METHODS 446
14.2.9 THERMAL ROUTES 448
14.3 C-DOTS-BASED FLUORESCENT PROBES FOR BIOIMAGING APPLICATIONS 450
14.3.1 FLUORESCENT PROBES FO R BIOIMAGING APPLICATIONS 450
14.3.2 IN VITRO IMAGING 451
14.3.3 IN VIVO IMAGING 456
14.3.4 CONCLUSION 462
14.4 TOXICITY ASSESSMENT 462
14.4.1 IN VITRO TOXICITY ASSESSMENT 463
14.4.2 IN VIVO TOXICITY ASSESSMENT 469
14.4.3 CONCLUSION 475
14.5 PERSPECTIVES 477
14.5.1 UNEQUIVOCAL PL MECHANISM 477
14.5.2 EXPANDING THE SPECTRAL COVERAGE 4
*
8
14.5.3 QY IM PROVEM ENT 478
14.5.4 BIOIMAGING 478
14.5.5 TOXICITY ASSESSMENT 479
REFERENCES 479
15
15.1
15.2
15.2.1
15.2.2
15.2.2.1
15.2.2.2
15.2.2.3
15.2.2.4
15.2.2.5
15.3
15.3.1
15.3.2
15.3.2.1
15.3.2.2
15.3.3
15.3.3.1
15.3.3.2
15.4
15.4.1
15.4.2
15.4.2.1
15.4.2.2
15.4.3
15.4.3.1
15.4.3.2
15.5
15.6
16
16.1
16.1.1
16.1.2
16.1.3
16.1.4
TRANSPORTIN THE ENVIRONMENT AND ECOTOXICITY OF CARBON
NANOMATERIALS 487
YINGYING XU AND CHUNYING CHEN
IN TRO D U CTIO N 487
TRANSPORT O F CARBON NANOMATERIALS IN THE ENVIRONM ENT 488
E NTRY O F CARBON NANOMATERIALS INTO THE ENVIRONM ENT 488
FATE AND TRANSFORM ATION IN THE ENVIRONM ENT 488
O XIDATION 488
PHOTOCHEMICAL TRANSFORM ATION 490
DISSOLUTION AND PRECIPITATION 491
A DSORPTION 492
BIODEGRADATION 493
ECOTOXICITY O F FULLERENE 494
EFFECT O F FULLERENE ON M ICROORGANISM S 494
EFFECT O F FULLERENE ON ANIM ALS 495
EFFECT O F FULLERENE ON INVERTEBRATES 495
EFFECT O F FULLERENE ON VERTEBRATES 496
EFFECT O F FULLERENE ON PLANTS 496
EFFECT O F FULLERENE ON ALGAE 496
EFFECT O F FULLERENE ON HIGHER PLANTS 497
ECOTOXICITY O F CARBON NANOTUBES (CNTS) 498
EFFECT O FC N T S ON MICROORGANISM S 498
EFFECT O F CNTS ON ANIM ALS 499
EFFECT O F CNTS ON INVERTEBRATES 499
EFFECT O F CNTS ON VERTEBRATES SOI
EFFECT O F CNTS ON PLANTS 502
EFFECT O F CNTS ON ALGAE 502
EFFECT O F CNTS ON H IGHER PLANTS 503
ECOTOXICITY O F GRAPHENE 504
CONCLUSION AND PERSPECTIVES 506
ACKNOWLEDGMENTS 506
REFERENCES 506
EXPOSURE SCENARIOS IN THE WORKPLACE AND RISK ASSESSMENT OF CARBON
NANOMATERIALS 515
RUI CHEN AND CHUNYING CHEN
IN TRO D U CTIO N 515
BACKGROUND 515
EXPOSURE ROUTES AND EXPOSURE SCENARIOS 515
EXPOSURE M ETRICS 516
OCCUPATION EXPOSURE L IM IT FO R CARBON NANOMATERIALS 5 *6
16.1.5 STRATEGY FOR EXPOSURE ASSESSMENT O F C F E 517
16.2 POTENTIAL EXPOSURE IN THE W ORKPLACE 519
16.2.1 CARBON NANOTUBES 519
16.2.2 FULLERENES, METALLOFULLERENES, AND GRAPHENES 525
16.3 EXPOSURE RISK ASSESSMENT AND ENGINEERING C ONTROL 527
16.3.1 RISK A SESSM ENT STRATEGY ON CARBON NANOMATERIALS 527
16.3.2 INHALATION EXPOSURE ASSESSMENT M ETHOD 529
16.3.3 EXPOSURE CONTROLS 530
16.4 SUMMARY AND O UTLOOK 531
ACKNOWLEDGMENTS
* *
]
REFERENCES 531
INDEX 535
|
| any_adam_object | 1 |
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| author_facet | Chen, Chunying Wang, Haifang |
| building | Verbundindex |
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| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Werkstoffwissenschaften / Fertigungstechnik Medizin |
| format | Book |
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| id | DE-604.BV043288128 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:22:19Z |
| institution | BVB |
| isbn | 9783527338719 9783527692866 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028709343 |
| oclc_num | 927846194 |
| open_access_boolean | |
| owner | DE-11 DE-29T |
| owner_facet | DE-11 DE-29T |
| physical | XXVI, 543 Seiten Illustrationen, Diagramme (teilweise farbig) |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
| record_format | marc |
| spelling | Biomedical applications and toxicology of carbon nanomaterials edited by Chunying Chen, Haifand Wang Weinheim Wiley-VCH Verlag GmbH & Co. KGaA [2016] © 2016 XXVI, 543 Seiten Illustrationen, Diagramme (teilweise farbig) txt rdacontent n rdamedia nc rdacarrier Nanostrukturiertes Material (DE-588)4342626-8 gnd rswk-swf Nanomedizin (DE-588)1067838503 gnd rswk-swf Kohlenstoffverbindungen (DE-588)4164566-2 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf Kohlenstoffverbindungen (DE-588)4164566-2 s Nanostrukturiertes Material (DE-588)4342626-8 s Nanomedizin (DE-588)1067838503 s Toxikologie (DE-588)4060538-3 s DE-604 Chen, Chunying (DE-588)1025134648 edt Wang, Haifang (DE-588)1103031546 edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-69287-3 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-69288-0 Erscheint auch als Online-Ausgabe, PDF 978-3-527-69285-9 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028709343&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biomedical applications and toxicology of carbon nanomaterials Nanostrukturiertes Material (DE-588)4342626-8 gnd Nanomedizin (DE-588)1067838503 gnd Kohlenstoffverbindungen (DE-588)4164566-2 gnd Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4342626-8 (DE-588)1067838503 (DE-588)4164566-2 (DE-588)4060538-3 |
| title | Biomedical applications and toxicology of carbon nanomaterials |
| title_auth | Biomedical applications and toxicology of carbon nanomaterials |
| title_exact_search | Biomedical applications and toxicology of carbon nanomaterials |
| title_full | Biomedical applications and toxicology of carbon nanomaterials edited by Chunying Chen, Haifand Wang |
| title_fullStr | Biomedical applications and toxicology of carbon nanomaterials edited by Chunying Chen, Haifand Wang |
| title_full_unstemmed | Biomedical applications and toxicology of carbon nanomaterials edited by Chunying Chen, Haifand Wang |
| title_short | Biomedical applications and toxicology of carbon nanomaterials |
| title_sort | biomedical applications and toxicology of carbon nanomaterials |
| topic | Nanostrukturiertes Material (DE-588)4342626-8 gnd Nanomedizin (DE-588)1067838503 gnd Kohlenstoffverbindungen (DE-588)4164566-2 gnd Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Nanostrukturiertes Material Nanomedizin Kohlenstoffverbindungen Toxikologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028709343&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT chenchunying biomedicalapplicationsandtoxicologyofcarbonnanomaterials AT wanghaifang biomedicalapplicationsandtoxicologyofcarbonnanomaterials |