Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering
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| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | English |
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Cham ; Heidelberg ; New York ; Dordrecht ; London
Springer
[2015]
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| Schriftenreihe: | Springer Theses : Recognizing Outstanding Ph.D. Research
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| Online-Zugang: | DE-91 DE-703 Volltext Inhaltsverzeichnis Abstract |
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| 245 | 1 | 0 | |a Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering |c Kiyotaka Akabori |
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| 650 | 4 | |a Physical chemistry | |
| 650 | 4 | |a Cell membranes | |
| 650 | 4 | |a Crystallography | |
| 650 | 4 | |a Membranes (Biology) / Mechanical properties | |
| 650 | 4 | |a Membranes | |
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Datensatz im Suchindex
| DE-BY-TUM_katkey | 2160259 |
|---|---|
| _version_ | 1820851954981535744 |
| adam_text | STRUCTURE DETERMINATION OF HIV-1 TAT/FLUID PHASE MEMBRANES AND DMPC
RIPPLE PHASE USING X-RAY SCATTERING
/ AKABORI, KIYOTAKA
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
LIPID BILAYERS
TAT PEPTIDE
PB RIPPLE PHASE
STRUCTURAL AND MATERIAL PERTURBATIONS OF LIPID BILAYERS DUE TO HIV-1 TAT
PEPTIDE
INTRODUCTION
MATERIALS AND METHODS
ANALYSIS OF MOLECULAR DYNAMICS SIMULATION DATA
RESULTS
DISCUSSION
CONCLUSIONS
RIPPLE PHASE
INTRODUCTION
MATERIALS AND METHODS
LAXS DATA REDUCTION
RESULTS FOR FHK FORM FACTORS
MODELS TO FIT THE FHK AND OBTAIN THE PHASE FACTORS
ELECTRON DENSITY PROFILES AND COARSE GRAINED BILAYER STRUCTURE
NGIWAXS: RESULTS
TWAXS: RESULTS
THIN ROD MODEL
COMBINING WAXS AND LAXS RESULTS FOR THE MAJOR ARM
DISCUSSION
CONCLUSION
APPENDICES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
STRUCTURE DETERMINATION OF HIV-1 TAT/FLUID PHASE MEMBRANES AND DMPC
RIPPLE PHASE USING X-RAY SCATTERING
/ AKABORI, KIYOTAKA
: 2015
ABSTRACT / INHALTSTEXT
THIS THESIS IN BIOLOGICAL PHYSICS HAS TWO COMPONENTS, DESCRIBINGTHE
USE OF X-RAY SCATTERING TECHNIQUESTO STUDY THE STRUCTURE OF TWO
DIFFERENT STACKED LIPID MEMBRANE SYSTEMS. THE FIRST PART FOCUSES ON
THE INTERACTION BETWEEN A SHORT 11-MER PEPTIDE, TAT, WHICH IS PART OF
THE TAT PROTEIN IN THE HIV-1 VIRUS. ALTHOUGH HIGHLY POSITIVELY
CHARGED, THE TAT PROTEIN HAS BEEN SHOWN TO TRANSLOCATE THROUGH
HYDROCARBON LIPID BILAYERS EASILY, WITHOUT REQUIRING THE CELL’S
ENERGY, WHICH IS COUNTER TO ITS BORN SELF-ENERGY. IN THIS WORK TAT’S
LOCATION IN THE HEADGROUP REGION WAS DEMONSTRATED USING A COMBINED X-RAY
SCATTERING AND MOLECULAR DYNAMICS APPROACH. BILAYER THINNING WAS
OBSERVED AS WELL AS SOFTENING OF DIFFERENT MEMBRANE MIMICS DUE TO TAT.
IT WAS CONCLUDED THAT TAT’S HEADGROUP LOCATION, WHICH INCREASES THE
AREA/LIPID, AND ITS BILAYER SOFTENING LIKELY REDUCE THE ENERGY BARRIER
FOR PASSIVE TRANSLOCATION. THE SECOND PART IS A RIGOROUS INVESTIGATION
OF AN ENIGMATIC PHASE IN THE PHASE DIAGRAM OF THE LIPID
DIMYRISTOYLPHOSPHATIDYLCHOLINE (DMPC). THE RIPPLE PHASE HAS FASCINATED
MANY RESEARCHERS IN CONDENSED MATTER PHYSICS AND PHYSICAL CHEMISTRY AS
AN EXAMPLE OF PERIODICALLY MODULATED PHASES, WITH MANY THEORETICAL AND
SIMULATION PAPERS PUBLISHED. DESPITE SYSTEMATIC STUDIES OVER THE PAST
THREE DECADES, MOLECULAR DETAILS OF THE STRUCTURE WERE STILL LACKING.
BY OBTAINING THE HIGHEST RESOLUTION X-RAY DATA SO FAR, THIS WORK
REVEALED THE COMPLEX NATURE OF THE CHAIN PACKING, AS WELL AS CONFIRMING
THAT THE MAJOR SIDE IS THICKER THAN THE MINOR SIDE OF THE SAW-TOOTH
RIPPLE STRUCTURE. THE NEW MODEL SHOWS THAT THE CHAINS IN THE MAJOR ARM
ARE TILTED WITH RESPECT TO THE BILAYER NORMAL AND THAT THE CHAINS IN THE
MINOR ARM ARE SLIGHTLY MORE DISORDERED THAN ALL-TRANS GEL-PHASE CHAINS,
I.E., THE CHAINS IN THE MINOR ARM ARE MORE FLUID-LIKE. THIS WORK
PROVIDES THE HIGHEST RESOLUTION X-RAY STRUCTURE OF THE RIPPLE PHASE
TO-DATE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Akabori, Kiyotaka |
| author_facet | Akabori, Kiyotaka |
| author_role | aut |
| author_sort | Akabori, Kiyotaka |
| author_variant | k a ka |
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| dewey-full | 571.64 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.64 |
| dewey-search | 571.64 |
| dewey-sort | 3571.64 |
| dewey-tens | 570 - Biology |
| discipline | Physik Biologie |
| doi_str_mv | 10.1007/978-3-319-22210-3 |
| format | Thesis Electronic eBook |
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| id | DE-604.BV043209967 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T04:48:33Z |
| institution | BVB |
| isbn | 9783319222103 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028633128 |
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| physical | 1 Online Ressource (xx, 168 Seiten) Illustrationen |
| psigel | ZDB-2-PHA ZDB-2-PHA_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
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| publisher | Springer |
| record_format | marc |
| series2 | Springer Theses : Recognizing Outstanding Ph.D. Research |
| spellingShingle | Akabori, Kiyotaka Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering Physics Physical chemistry Cell membranes Crystallography Membranes (Biology) / Mechanical properties Membranes Membrane Biology Physical Chemistry |
| subject_GND | (DE-588)4113937-9 |
| title | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering |
| title_auth | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering |
| title_exact_search | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering |
| title_full | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering Kiyotaka Akabori |
| title_fullStr | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering Kiyotaka Akabori |
| title_full_unstemmed | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering Kiyotaka Akabori |
| title_short | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering |
| title_sort | structure determination of hiv 1 tat fluid phase membranes and dmpc ripple phase using x ray scattering |
| topic | Physics Physical chemistry Cell membranes Crystallography Membranes (Biology) / Mechanical properties Membranes Membrane Biology Physical Chemistry |
| topic_facet | Physics Physical chemistry Cell membranes Crystallography Membranes (Biology) / Mechanical properties Membranes Membrane Biology Physical Chemistry Hochschulschrift |
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