Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases
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| Format: | Elektronisch E-Book |
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| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific
c2012
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| Schlagworte: | |
| Online-Zugang: | DE-1046 DE-1047 Volltext |
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| Beschreibung: | What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons Ch. 1. The cellular process of autophagy and control of autophagy in neurons / Nicole C. McKnight, Noboru Mizushima and Zhenyu Yue -- ch. 2. Autophagosome maturation, endocytosis and neurodegenerative disease / Ai Yamamoto and Anne Simonsen -- ch. 3. Cross-talk between the ubiquitin-proteasome system and macroautophagy / Serhiy Pankiv and Terje Johansen -- ch. 4. Chaperone-mediated autophagy (CMA) in neurons / Maria Xilouri, Hsiao-Yu Peng and Leonidas Stefanis -- ch. 5. Maintaining autophagic balance: a role for brakes / Salvatore J. Cherra, III and Charleen T. Chu -- ch. 6. Autophagy and its cross-talk with cell death in neural development / Sabrina Di Bartolomeo and Francesco Cecconi -- ch. 7. Autophagy in the retina: development, physiology and pathology / Patricia Boya -- ch. 8. Genetic mouse models for elucidation of autophagy-lysosomal systems in neurons under physiologic and pathologic conditions / Masaaki Komatsu ... [et al.] -- - ch. 9. Autophagy in amyotrophic lateral sclerosis / Jozsef Gal and Haining Zhu -- ch. 10. Autophagy failure in Alzheimer's disease and lysosomal storage disorders: a common pathway to neurodegeneration? / Devin M. Wolfe and Ralph A. Nixon -- ch. 11. Autophagy in Huntington's and Parkinson's diseases: pathogenic mechanisms and therapeutic potentials / Junghyun Lim ... [et al.] -- ch. 12. Metabolism, autophagy and neurodegeneration / W. Haung Yu and Karen E. Duff -- ch. 13. The potential of autophagy regulation in the treatment of neurodegenerative diseases / Ashley R. Winslow, Zeyn W. Green-Thompson and David C. Rubinsztein -- ch. 14. Lysosome storage disorders on the brain: the autophagy-lysosome pathway contributes to disease pathophysiology and may be utilized for therapeutic benefit / John J. Shacka -- ch. 15. Autophagy -- roles in synaptic structure and function / Daniela Hernandez and David Sulzer -- - ch. 16. Neuronal mitochondrial transport and turnover via mitophagy / Zu-Hang Sheng and Charleen T. Chu -- ch. 17. Role of autophagy in neurite degeneration in vitro / Yi Yang, Xiaoxiang Zheng and Tatsuro Koike |
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| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9789814350440 9789814350457 9814350443 9814350451 |