Immunology
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
2010
|
| Schriftenreihe: | Fundamentals of biomedical science
|
| Schlagworte: | |
| Online-Zugang: | DE-1046 DE-1047 Volltext |
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Inhaltsangabe:
- Chapter 1: Introduction To The Clinical Immunology Laboratory / Angela Hall and Don Henderson
- Introduction
- 1-1: Immunology
- 1-2: Immunology in biomedical science
- Chapter summary
- Discussion questions
- Chapter 2: Immunoglobulins / Lynn Follows and Phillip A Whitfield
- Introduction
- 2-1: Immunoglobulins
- 2-2: Monoclonal gammopathies
- 2-3: Quantification of immunoglobulins
- 2-4: Cerebrospinal fluid and isoelectric focusing
- 2-5: Cryoglobulins
- Chapter summary
- Further reading
- Discussion questions
- Chapter 3: Allergy / Alistair Crockard and I J Ansotegui
- Introduction
- 3-1: Allergy terminology
- 3-2: Allergens
- 3-3: Allergy mechanisms
- 3-4: Clinical features of allergic diseases
- 3-5: Clinical diagnosis
- 3-6: Laboratory diagnosis
- 3-7: Allergen standardization
- 3-8: Cross-reactivity
- 3-9: Recombinant allergens
- 3-10: Microarray-based allergy testing
- 3-11: Quality assurance
- 3-12: Total IgE measurements
- 3-13: IgG antibodies
- 3-14: Flow cytometric analyses
- 3-15: Measurement of mediators released during allergic reactions
- 3-16: Mast cell tryptase
- 3-17: Eosinophil cationic protein (ECP)
- Chapter summary
- Further reading
- Discussion questions
- Chapter 4: Complement / Mo Moody, Tariq El-Shanawany, Paul Williams and B Paul Morgan
- Introduction
- 4-1: Actions of complement
- 4-2: Regulation of complement
- 4-3: Complement deficiencies
- 4-4: Measurement of complement activity
- 4-5: Cl inhibitor deficiency
- 4-6: Autoantibodies against complement components and complexes
- 4-7: Complement allotyping
- Chapter summary
- Further reading
- Discussion questions
- Chapter 5: Autoimmune Rheumatological Disease / Peter J Charles
- Introduction
- 5-1: Systemic lupus erythematosus (SLE)
- 5-2: Rheumatoid arthritis (RA)
- 5-3: Scleroderma
- 5-4: Sjogren's syndrome
- 5-5: Polymyositis and dermatomyositis
- 5-6: Anti-phospholipid syndrome (APS)
- 5-7: Overlapping connective tissue diseases
- 5-8: Autoantibodies
- Chapter summary
- Further reading
- Discussion questions
- Chapter 6: Autoimmune Kidney Disease / Peter J Charles
- Introduction
- 6-1: Goodpasture's (anti-GBM) disease
- 6-2: Wegener's granulomatosis
- 6-3: Microscopic polyangiitis (MPA)
- 6-4: Autoantibodies in autoimmune kidney diseases
- 6-5: Aetiology and pathogenesis of ANCA antibodies
- 6-6: Methods of detection
- Chapter summary
- Further reading
- Discussion questions
- Chapter 7: Organ-Specific Autoimmunity / Robert J Lock
- Introduction
- 7-1: Autoimmune thyroid disease
- 7-2: Coeliac disease
- 7-3: Pernicious anaemia
- 7-4: Autoimmune endocrinopathies
- Chapter summary
- Further reading
- Discussion questions
- Chapter 8: Autoimmune Liver Diseases / Edward Davies
- Introduction
- 8-1: Autoimmune hepatitis (AIH)
- 8-2: Autoimmune sclerosing cholangitis (ASC)
- 8-3: Primary biliary cirrhosis (PBC)
- 8-4: Overlap syndromes
- 8-5: Technical notes
- Chapter summary
- Further reading
- Discussion questions
- Chapter 9: Neuroimmunology / Abid R Karmin and S Jacob
- Introduction
- 9-1: Epidemiology of paraneoplastic syndrome
- 9-2: Clinical features of paraneoplastic syndromes
- 9-3: Malignancies commonly associated with PNS
- 9-4: Paraneoplastic neurological antibodies (PNA)
- 9-5: Well-characterized antibodies
- 9-6: Partially characterized antibodies
- 9-7: Antibodies with or without cancer
- 9-8: Treatment of paraneoplastic syndromes
- 9-9: Miscellaneous antibodies
- Chapter summary
- Further reading
- Acknowledgements
- Discussion questions
- Chapter 10: Flow Cytometry And Primary Immunodeficiency / Dawn Barge
- Introduction
- 10-1: Lymphocyte subsets
- 10-2: T cells
- 10-3: B cells
- 10-4: Natural killer (NK) cells
- 10-5: Additional antibodies
- 10-6: Inducible antigens
- 10-7: Intracellular staining
- 10-8: Functional assays
- 10-9: Neutrophil defects
- Chapter summary
- Further reading
- Discussion questions
- Chapter 11: Human Immunodeficiency Virus (HIV) / Alison Cox
- Introduction
- 11-1: Human immunodeficiency virus
- 11-2: Life cycle of HIV
- 11-3: Transmission of HIV
- 11-4: Effects of HIV on the immune system
- 11-5: Clinical features of HIV infection
- 11-6: Progression to AIDS
- 11-7: Laboratory diagnosis of HIV infection
- 11-8: Treatment regimens for HIV-1 infections
- 11-9: Prevention of HIV transmission and infection
- Chapter summary
- Discussion questions
- References
- Glossary
- Abbreviations
- Hints and tips for discussion questions
- Index
- From the Publisher: Designed to reflect the challenges of practicing biomedical science today, The Fundamentals of Biomedical Science series combines essential basic science with insights into laboratory practice, demonstrating how an understanding of the biology of disease is coupled with the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a biomedical scientist may be exposed, from microbiology to cytopathology to transfusion science. A new volume in this exciting series, Immunology offers biomedical science students insights into the function of the immune system, the frontline of defense against pathological disease, and the diagnostic techniques used to identify associated malfunctions and disorders. By examining the key immunological principles and scientific basis of laboratory techniques-with a focus on the biomedical scientist's role in the diagnostic laboratory-the authors provide students with everything they need to know in order to prepare for specialist studies in immunology. Case studies cover current tests, the rationale behind their use, the technologies employed, the quality measures applied, and the ways in which clinicians interpret test results in order to help patients. Immunology is enhanced by numerous examples and full color throughout. A Companion Website offers resources for students and instructors, including a fully interactive digital microscope with a range of cell and tissue images for examination