Host response to biomaterials the impact of host response on biomaterial selection
Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Amsterdam
Academic Press
[2015]
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| 245 | 1 | 0 | |a Host response to biomaterials |b the impact of host response on biomaterial selection |c edited by Stephen F. Badylak |
| 264 | 1 | |a Amsterdam |b Academic Press |c [2015] | |
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| 500 | |a Includes bibliographical references and index | ||
| 520 | |a Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine | ||
| 650 | 7 | |a MEDICAL / Surgery / General |2 bisacsh | |
| 650 | 4 | |a Medizin | |
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Datensatz im Suchindex
| _version_ | 1819760274494717952 |
|---|---|
| adam_text | Titel: Host response to biomaterials
Autor: Badylak, Stephen F
Jahr: 2015
CONTENTS
List of Contributors xi
Foreword xiii
Preface xv
Acknowledgments xvii
1. Factors Which Affect the Host Response to Biomaterials 1
Ricardo Londono and Stephen F. Badylak
Introduction 1
Biomaterial-Host Interaction 2
Host Factors 4
Age 4
Nutritional Status 6
Anatomic Factors 7
Comorbidities 8
Chemotherapy and Radiation Therapy 9
Design Considerations 10
References 10
2. Perspectives on the Inflammatory, Healing, and Foreign Body Responses to
Biomaterials and Medical Devices 13
James Anderson and Stephanie Cramer
Introduction 13
Blood-Material Interactions/Provisional Matrix Formation 15
Acute Inflammation 18
Chronic Inflammation 20
Granulation Tissue 24
Foreign Body Reaction 25
Fibrosis/Fibrous Encapsulation 28
Innate and Adaptive Immune Responses 30
Discussion and Perspectives 30
References 33
3. The Biocompatibility of Implant Materials 37
Buddy D. Ratner
Introduction 37
The Meaning of Biocompatibility 38
vi Contents
Biocompatibility: Historical Thinking 38
Biocompatibility Today 39
Changing the Paradigm of Biocompatibility 45
Relevance to Biocompatibility 47
Conclusions 48
References 49
4. Host Response to Naturally Derived Biomaterials 53
Samuel T. Lopresti and Bryan N. Brown
Introduction 53
The Use of Decellularized Tissue as a Biomaterial for Surgical Reconstruction
and Constructive Remodeling 56
Immune Rejection 58
Decellularization Processes 58
or-Gal Epitope 59
DNA Content and Degree of Decellularization 62
Damage-Associated Molecular Pattern Molecules 63
Chemical Cross-Linking of ECM Scaffolds 64
Response to Individual ECM Components and Degradation Products 64
Degradation of Naturally Derived Biomaterials 65
Effect of Source Animal Age on Natural Biomaterial Host Response 67
The Host Response to ECM Biomaterials 68
Th 1 - and Th2-Lymphocyte Response 69
Macrophage Polarization 70
Conclusion 72
References 73
5. Molecular Events at Tissue-Biomaterial Interface 81
Themis R. Kyriakides
General Principles Guiding Protein Interactions at the Biomaterial Interface 82
Cell-Protein Interactions at the Interface 88
Molecular Pathways in the Regulation of Cell Activation and Cell-Cell Interactions 94
Molecular Pathways Mediating Tissue Remodeling at the Interface 102
Acknowledgments 112
References 112
6. Macrophage Plasticity and Polarization: Relevance to Biomaterials 117
Maria Rosaria Galdiero and Alberto Mantovani
Macrophage Diversity and Plasticity 117
Macrophage Polarization: M1 and M2 as Extremes of a Continuum. Limitations of the Paradigm 118
Contents vii
Macrophages in the Orchestration ofTissue Repair 120
Macrophage Polarization in the Response to Biomaterials 124
Concluding Remarks 127
Acknowledgments 127
References 128
7. Role of Dendritic Cells in Response to Biomaterials 131
Jamal S. Lewis and Benjamin G. Keselowsky
Introduction 131
DC Immuno-Biology 134
DC Responses to Biomaterials 140
Conclusion—DC Role in Host Responses to Biomaterials 146
References 146
8. The Acquired Immune System Response to Biomaterials, Including
Both Naturally Occurring and Synthetic Biomaterials 151
Jonathan M. Fishman, Katherine Wiles and Kathryn J. Wood
Introduction 151
The Immune System and Graft Rejection 153
Biomaterials as Scaffolds for Tissue Engineering 162
The Adaptive Host Immune Response to Biomaterials 172
Generation of an Immunosuppression-Free State 174
Future Work and Conclusions 177
References 177
9. Fibrotic Response to Biomaterials and all Associated Sequence of
Fibrosis 189
Kim Jones
Introduction 190
Biomaterials and the Wound Healing Paradigm 191
Clinical Applications of Biomaterials Affected by Fibrosis 194
General Mechanisms of Fibrosis 199
Initiation of Fibrosis 200
Cellular Contributors to Fibrosis 205
Molecular Mediators of Fibrosis 211
Engineering Anti-Fibrotic Responses to Biomaterials 219
Conclusions 223
References 224
viii Contents
10. Human Anti-Gal and Anti-Non-Gal Immune Response to
Porcine Tissue Implants 239
Uri Galili
Introduction 239
Immune Mechanisms That Affect Tissue Implants 240
The Anti-Gal Antibody and the a-Gal Epitope 241
Production of Anti-Non-Gal Antibodies in Humans 253
Conclusions 262
References 262
11. Aging and the Host Response to Implanted Biomaterials 269
Archana N. Rao, Mahender N. Avula and David W. Grainger
Introduction 269
The Host FBR 271
Host Inflammatory Response 272
The Host Immune Response 275
Complement Activation 276
The Coagulation Cascade 278
Aging-Related Changes in Inflammation, Immune Response, Coagulation, and Complement
Activation 280
Aging and Immune Functional Changes: Immunosenescence and Changes in Cell Functions,
Signaling, and Cell-Cell Interactions 288
Conclusions 301
Acknowledgment 303
References 303
12. Host Response to Orthopedic Implants (Metals and Plastics) 315
Zhenyu Yao,Tzu-Hua Lin, Jukka Pajarinen,Taishi Sato and Stuart Goodman
Introduction—Epidemiology and Basic Concepts/Definitions 316
Joint Replacement 319
Other Clinical Scenarios 324
Immune Responses to Biomaterials for Orthopedic Applications—Preclinical Studies 325
Modulating the Host Response to Orthopedic Implants 336
Summary and Future Directions 354
References 355
13. Host Response to Biomaterials for Pelvic Floor Reconstruction 375
William R. Barone, Steven D. Abramowitch and Pamela A. Moalli
Introduction 376
Pelvic Floor Anatomy 376
Contents ix
Pelvic Floor Disorders 384
Biomaterial-Related Complications in the Pelvic Floor 398
Factors Influencing the Host Response to Synthetic Mesh 401
Pelvic Floor Considerations for Mesh Implants 408
Looking to the Future 416
References 417
14. Methods Used to Evaluate the Host Responses to Medical Implants In Vivo 425
David W. Baker, Jun Zhou and Liping Tang
Introduction 425
Ex Vivo Methods to Evaluate the Host Response 426
Early Detection of Molecular Cues and Events 429
Methods to Evaluate Innate Immune Responses Leading to Inflammation and Fibrosis 432
Mathematical Modeling and Prediction Methods 434
Conclusion and Summary 436
References 436
Index
441
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| indexdate | 2024-12-24T04:37:08Z |
| institution | BVB |
| isbn | 9780128005002 0128005009 9780128001967 |
| language | English |
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| spellingShingle | Host response to biomaterials the impact of host response on biomaterial selection MEDICAL / Surgery / General bisacsh Medizin Biomedical materials Tissue engineering Natural immunity |
| title | Host response to biomaterials the impact of host response on biomaterial selection |
| title_auth | Host response to biomaterials the impact of host response on biomaterial selection |
| title_exact_search | Host response to biomaterials the impact of host response on biomaterial selection |
| title_full | Host response to biomaterials the impact of host response on biomaterial selection edited by Stephen F. Badylak |
| title_fullStr | Host response to biomaterials the impact of host response on biomaterial selection edited by Stephen F. Badylak |
| title_full_unstemmed | Host response to biomaterials the impact of host response on biomaterial selection edited by Stephen F. Badylak |
| title_short | Host response to biomaterials |
| title_sort | host response to biomaterials the impact of host response on biomaterial selection |
| title_sub | the impact of host response on biomaterial selection |
| topic | MEDICAL / Surgery / General bisacsh Medizin Biomedical materials Tissue engineering Natural immunity |
| topic_facet | MEDICAL / Surgery / General Medizin Biomedical materials Tissue engineering Natural immunity |
| url | http://www.sciencedirect.com/science/book/9780128001967 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028367345&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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