Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf
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| Format: | Elektronisch E-Book |
| Sprache: | German |
| Veröffentlicht: |
Wiesbaden
VS Verlag für Sozialwissenschaften
1975
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| Schriftenreihe: | Rheinisch-Westfälische Akademie der Wissenschaften, Natur-, Ingenieur- und Wirtschaftswissenschaften Vorträge
246 |
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| Online-Zugang: | FLA01 UBY01 Volltext |
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| 245 | 1 | 0 | |a Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht |b 224. Sitzung am 3. April 1974 in Düsseldorf |c von Theodor Wieland, Karl-Dietrich Gundermann |
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| 490 | 0 | |a Rheinisch-Westfälische Akademie der Wissenschaften, Natur-, Ingenieur- und Wirtschaftswissenschaften Vorträge |v 246 | |
| 500 | |a The slowly acting amatoxins bind to the DNA dependent nucleoplas mic RNA polymerase B (II) which is responsible for the transscription of m-RNA. This enables one to discriminate between form Band polymerase A (I), the enzyme catalyzing r-RNA synthesis, and to recognize all bio logical events depending on m-RNA synthesis (protein synthesis after hormonal stimulation, growth of certain virus species etc.). Also with the amatoxins is the affinity for the receptor dependent on the conformation, visible by ORD and CD. All of the toxic derivatives are inhibitory, whereas not all of the inhibitory ones are toxic. This descrepancy is, in part, resolved by the observation of nontoxic "amanullins" dissociating more than ten times fast er from the enzyme than toxic ones. The quickly acting phallotoxins bind to a protein closely associated with the cytoplasmic membrane of the liver cell so causing the formation of microfilaments, the nature of which as actin has been proven by deco ration with heavy meromyosin. Accordingly phallotoxins also bind to muscle actin which in presence of ADP and Mg++ immediately polym erizes to a phallotoxin containing F -actin (Ph-actin). Ph-actin is also formed from F -actin by re action with phallotoxins. It differs from F -actin by its resistance against 0.6 M KI. Responsible for its toxic properties is the conformation of the molecule as can be followed by ORD and CD spectroscopy and the presence of a special methyl and hydroxyl group | ||
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Datensatz im Suchindex
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| author | Wieland, Theodor 1913-1995 |
| author_GND | (DE-588)117750050 |
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| bvnumber | BV042457314 |
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| dewey-full | 50 |
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| dewey-search | 50 |
| dewey-sort | 250 |
| dewey-tens | 050 - General serial publications |
| discipline | Allgemeine Naturwissenschaft |
| doi_str_mv | 10.1007/978-3-322-85474-2 |
| format | Electronic eBook |
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| id | DE-604.BV042457314 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:22:16Z |
| institution | BVB |
| isbn | 9783322854742 9783531082462 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027892521 |
| oclc_num | 915599739 |
| open_access_boolean | |
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| owner_facet | DE-634 DE-188 DE-860 DE-706 |
| physical | 1 Online-Ressource (78S.) |
| psigel | ZDB-2-SGR ZDB-2-BAD ZDB-2-SGR_Archive ZDB-2-SGR_1815/1989 |
| publishDate | 1975 |
| publishDateSearch | 1975 |
| publishDateSort | 1975 |
| publisher | VS Verlag für Sozialwissenschaften |
| record_format | marc |
| series2 | Rheinisch-Westfälische Akademie der Wissenschaften, Natur-, Ingenieur- und Wirtschaftswissenschaften Vorträge |
| spelling | Wieland, Theodor 1913-1995 Verfasser (DE-588)117750050 aut Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf von Theodor Wieland, Karl-Dietrich Gundermann Wiesbaden VS Verlag für Sozialwissenschaften 1975 1 Online-Ressource (78S.) txt rdacontent c rdamedia cr rdacarrier Rheinisch-Westfälische Akademie der Wissenschaften, Natur-, Ingenieur- und Wirtschaftswissenschaften Vorträge 246 The slowly acting amatoxins bind to the DNA dependent nucleoplas mic RNA polymerase B (II) which is responsible for the transscription of m-RNA. This enables one to discriminate between form Band polymerase A (I), the enzyme catalyzing r-RNA synthesis, and to recognize all bio logical events depending on m-RNA synthesis (protein synthesis after hormonal stimulation, growth of certain virus species etc.). Also with the amatoxins is the affinity for the receptor dependent on the conformation, visible by ORD and CD. All of the toxic derivatives are inhibitory, whereas not all of the inhibitory ones are toxic. This descrepancy is, in part, resolved by the observation of nontoxic "amanullins" dissociating more than ten times fast er from the enzyme than toxic ones. The quickly acting phallotoxins bind to a protein closely associated with the cytoplasmic membrane of the liver cell so causing the formation of microfilaments, the nature of which as actin has been proven by deco ration with heavy meromyosin. Accordingly phallotoxins also bind to muscle actin which in presence of ADP and Mg++ immediately polym erizes to a phallotoxin containing F -actin (Ph-actin). Ph-actin is also formed from F -actin by re action with phallotoxins. It differs from F -actin by its resistance against 0.6 M KI. Responsible for its toxic properties is the conformation of the molecule as can be followed by ORD and CD spectroscopy and the presence of a special methyl and hydroxyl group Science (General) Science, general Naturwissenschaft Gundermann, Karl-Dietrich Sonstige oth https://doi.org/10.1007/978-3-322-85474-2 Verlag Volltext |
| spellingShingle | Wieland, Theodor 1913-1995 Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf Science (General) Science, general Naturwissenschaft |
| title | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf |
| title_auth | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf |
| title_exact_search | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf |
| title_full | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf von Theodor Wieland, Karl-Dietrich Gundermann |
| title_fullStr | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf von Theodor Wieland, Karl-Dietrich Gundermann |
| title_full_unstemmed | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht 224. Sitzung am 3. April 1974 in Düsseldorf von Theodor Wieland, Karl-Dietrich Gundermann |
| title_short | Cyclische Peptide als Werkzeuge der molekularbiologischen Forschung. Grundlagen und Anwendungsmöglichkeiten von Chemilumineszenz, der Umwandlung von chemischer Energie in Licht |
| title_sort | cyclische peptide als werkzeuge der molekularbiologischen forschung grundlagen und anwendungsmoglichkeiten von chemilumineszenz der umwandlung von chemischer energie in licht 224 sitzung am 3 april 1974 in dusseldorf |
| title_sub | 224. Sitzung am 3. April 1974 in Düsseldorf |
| topic | Science (General) Science, general Naturwissenschaft |
| topic_facet | Science (General) Science, general Naturwissenschaft |
| url | https://doi.org/10.1007/978-3-322-85474-2 |
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