Multiple aspects of DNA and RNA from biophysics to bioinformatics

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Körperschaft: Ecole d'été de physique théorique (Les Houches, Haute-Savoie, France) < 2004> (VerfasserIn)
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Sprache:English
Veröffentlicht: Amsterdam Elsevier 2005
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246 1 3 |a Les Houches, session LXXXII, NATO ASI 
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500 |a This book is dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules. These molecules, central to vital processes, have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by Watson and Crick in 1953. Recent progresses (e.g. use of DNA chips, manipulations at the single molecule level, availability of huge genomic databases ...) have revealed an imperious need for theoretical modelling. Further progresses will clearly not be possible without an integrated understanding of all DNA and RNA aspects and studies. The book is intended to be a desktop reference for advanced graduate students or young researchers willing to acquire a broad interdisciplinary understanding of the multiple aspects of DNA and RNA. It is divided in three main sections: The first section comprises an introduction to biochemistry and biology of nucleic acids.  
500 |a The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription. These chapters does not require any preliminary knowledge in the field (except that of elementary biology and chemistry). The second section covers the biophysics of DNA and RNA, starting with basics in polymer physics in the contribution by R. Khokhlov. A large space is then devoted to the presentation of recent experimental and theoretical progresses in the field of single molecule studies. T. Strick's contribution presents a detailed description of the various micro-manipulation techniques, and reviews recent experiments on the interactions between DNA and proteins (helicases, topoisomerases ...). The theoretical modeling of single molecules is presented by J.  
500 |a Marko, with a special attention paid to the elastic and topological properties of DNA. Finally, advances in the understanding of electrophoresis, a technique of crucial importance in everyday molecular biology, are exposed in T. Duke's contribution. The third section presents provides an overview of the main computational approaches to integrate, analyse and simulate molecular and genetic networks. First, J. van Helden introduces a series of statistical and computational methods allowing the identification of short nucleic fragments putatively involved in the regulation of gene expression from sets of promoter sequences controlling co-expressed genes. Next, the chapter by Samsonova et al. connects this issue of transcriptional regulation with that of the control of cell differentiation and pattern formation during embryonic development. Finally, H. de Jong and D.  
500 |a Thieffry review a series of mathematical approaches to model the dynamical behaviour of complex genetic regulatory networks. This contribution includes brief descriptions and references to successful applications of these approaches, including the work of B. Novak, on the dynamical modelling of cell cycle in different model organisms, from yeast to mammals. . Provides a comprehensive overview of the structure and function of DNA and RNA at the interface between physics, biology and information science 
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Datensatz im Suchindex

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spelling Ecole d'été de physique théorique (Les Houches, Haute-Savoie, France) < 2004> Verfasser aut
Multiple aspects of DNA and RNA from biophysics to bioinformatics edited by Didier Chatenay ... [et al.]
Multiple aspects of deoxyribonucleic acid and ribonucleic acid
From biophysics to bioinformatics
École d'été de physique des Houches, session LXXXII, 2-27 August 2004
Les Houches, session LXXXII, NATO ASI
1st ed
Amsterdam Elsevier 2005
1 Online-Ressource (xxiv, 354 p.)
txt rdacontent
c rdamedia
cr rdacarrier
"Euro Summer School, NATO Advanced Study Institute, École Thématique du CNRS."
At head of title: École d'été de physique des Houches, session LXXXII, 2-27 August 2004. - Les Houches, session LXXXII, NATO ASI
This book is dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules. These molecules, central to vital processes, have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by Watson and Crick in 1953. Recent progresses (e.g. use of DNA chips, manipulations at the single molecule level, availability of huge genomic databases ...) have revealed an imperious need for theoretical modelling. Further progresses will clearly not be possible without an integrated understanding of all DNA and RNA aspects and studies. The book is intended to be a desktop reference for advanced graduate students or young researchers willing to acquire a broad interdisciplinary understanding of the multiple aspects of DNA and RNA. It is divided in three main sections: The first section comprises an introduction to biochemistry and biology of nucleic acids.
The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription. These chapters does not require any preliminary knowledge in the field (except that of elementary biology and chemistry). The second section covers the biophysics of DNA and RNA, starting with basics in polymer physics in the contribution by R. Khokhlov. A large space is then devoted to the presentation of recent experimental and theoretical progresses in the field of single molecule studies. T. Strick's contribution presents a detailed description of the various micro-manipulation techniques, and reviews recent experiments on the interactions between DNA and proteins (helicases, topoisomerases ...). The theoretical modeling of single molecules is presented by J.
Marko, with a special attention paid to the elastic and topological properties of DNA. Finally, advances in the understanding of electrophoresis, a technique of crucial importance in everyday molecular biology, are exposed in T. Duke's contribution. The third section presents provides an overview of the main computational approaches to integrate, analyse and simulate molecular and genetic networks. First, J. van Helden introduces a series of statistical and computational methods allowing the identification of short nucleic fragments putatively involved in the regulation of gene expression from sets of promoter sequences controlling co-expressed genes. Next, the chapter by Samsonova et al. connects this issue of transcriptional regulation with that of the control of cell differentiation and pattern formation during embryonic development. Finally, H. de Jong and D.
Thieffry review a series of mathematical approaches to model the dynamical behaviour of complex genetic regulatory networks. This contribution includes brief descriptions and references to successful applications of these approaches, including the work of B. Novak, on the dynamical modelling of cell cycle in different model organisms, from yeast to mammals. . Provides a comprehensive overview of the structure and function of DNA and RNA at the interface between physics, biology and information science
Includes bibliographical references
Conference proceedings fast
DNA / Congresses
RNA / Congresses
Biophysics / Congresses
Computational Biology / Congresses
Models, Biological / Congresses
Biophysics fast
Computational biology fast
Nucleic acids fast
Nucleic acids Congresses
Biophysics Congresses
Computational biology Congresses
(DE-588)1071861417 Konferenzschrift gnd-content
Chatenay, Didier Sonstige oth
http://www.sciencedirect.com/science/book/9780444520814 Verlag Volltext
spellingShingle Multiple aspects of DNA and RNA from biophysics to bioinformatics
Conference proceedings fast
DNA / Congresses
RNA / Congresses
Biophysics / Congresses
Computational Biology / Congresses
Models, Biological / Congresses
Biophysics fast
Computational biology fast
Nucleic acids fast
Nucleic acids Congresses
Biophysics Congresses
Computational biology Congresses
subject_GND (DE-588)1071861417
title Multiple aspects of DNA and RNA from biophysics to bioinformatics
title_alt Multiple aspects of deoxyribonucleic acid and ribonucleic acid
From biophysics to bioinformatics
École d'été de physique des Houches, session LXXXII, 2-27 August 2004
Les Houches, session LXXXII, NATO ASI
title_auth Multiple aspects of DNA and RNA from biophysics to bioinformatics
title_exact_search Multiple aspects of DNA and RNA from biophysics to bioinformatics
title_full Multiple aspects of DNA and RNA from biophysics to bioinformatics edited by Didier Chatenay ... [et al.]
title_fullStr Multiple aspects of DNA and RNA from biophysics to bioinformatics edited by Didier Chatenay ... [et al.]
title_full_unstemmed Multiple aspects of DNA and RNA from biophysics to bioinformatics edited by Didier Chatenay ... [et al.]
title_short Multiple aspects of DNA and RNA
title_sort multiple aspects of dna and rna from biophysics to bioinformatics
title_sub from biophysics to bioinformatics
topic Conference proceedings fast
DNA / Congresses
RNA / Congresses
Biophysics / Congresses
Computational Biology / Congresses
Models, Biological / Congresses
Biophysics fast
Computational biology fast
Nucleic acids fast
Nucleic acids Congresses
Biophysics Congresses
Computational biology Congresses
topic_facet Conference proceedings
DNA / Congresses
RNA / Congresses
Biophysics / Congresses
Computational Biology / Congresses
Models, Biological / Congresses
Biophysics
Computational biology
Nucleic acids
Nucleic acids Congresses
Biophysics Congresses
Computational biology Congresses
Konferenzschrift
url http://www.sciencedirect.com/science/book/9780444520814
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