Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol-linked proteins
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| Format: | Elektronisch E-Book |
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| Sprache: | English |
| Veröffentlicht: |
San Diego
Academic Press
©2000
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| Online-Zugang: | Volltext |
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| Beschreibung: | Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins Includes bibliographical references and index |
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| Beschreibung: | 1 Online-Ressource (xiii, 279 pages) |
| ISBN: | 9780127729404 0127729402 9780080492094 0080492096 |