Novel immune potentiators and delivery technologies for next generation vaccines

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Veröffentlicht: New York [u.a.] Springer 2013
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Datensatz im Suchindex

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adam_text Contents Section I Novel Immune Potentiators and Delivery Systems for Enhancing Vaccine Potency 1 TLR7/8 Agonists as Vaccine Adjuvants ............................................... 3 Mark A. Tomai and John P. Vasi lakos 2 Preclinical and Clinical Development of Synthetic iNKT-Cell Glycolipid Agonists as Vaccine Adjuvants ........................................... 19 Josianne Nitcheu, Sandrine Crabe, Gwyn Davies, and Vincent Serra 3 Mu cosai Vaccination: Opportunities and Challenges ......................... 65 Olga Borges and Gerrit В orchard 4 Oral Vaccination: Attenuated and Gene-Based .................................. 81 Wendy Peters, Ciaran D. Scałlan, and Sean N. Tucker Section Π Design and Development of Next Generation Vaccines 5 Development of Biophysical Assays to Better Understand Adjuvanted Vaccine Formulation Potency and Stability ................... 107 James Chesko, Thomas Vedvick, and Steve Reed 6 High Throughput Screening for Stabilizers of Vaccine Antigens ...... 119 C. Russell Middaugh, David B. Volkin, and Sangeeta B. Joshi 7 Exploring Novel Analytical Tools to Improve Characterization of Vaccine Formulations ........................................................................ 145 Michele Pallaoro 8 bnnaunobioengjiieering Approaches Towards Combinatorial Delivery of Immune-Modulators and Antigens ................................... 161 Ankur Singh, Pallab Pradhan, and Krishnendu Roy Vii viii Contents Section HI Novel Delivery Technologies for Vaccines 9 Current Status of Electroporation Technologies for Vaccine Delivery ............................................................................... 185 Claire F. Evans and Drew Harmaman 10 M і ero needles for IntradermaJ Vaccination: Lmmunopotentiation and Formulation Aspects ....................................................................... 217 Alexander K. Andrianov 11 MicroCor® Transdermal Delivery System: A Safe, Efficient, and Convenient Transdermal System for Vaccine Administration ................................................................... 233 Parminder Singh, Guohua Chen, and Wade Worsham 12 Mimopath™-Based Vaccine Delivery .................................................. 245 Kees Leenhouts Section IV Novel Particulate Delivery Systems for Vaccines and Adjuvants 13 NanoBio™ Nanoemulsion for Mucosal Vaccine Delivery .................. 269 Tarek Hamouda, Jakub Simon, Ali Fattom, and James Baker 14 Influenza Virosomes as Antigen Delivery System ............................... 287 Christian Moser and Mario Amacker 15 Matrix M Adjuvant Technology ........................................................... 309 Karm Lövgren Bengtsson Section V Safety Assessment of Next Generation Vaccines 16 S trategies for the NoncJinical Safety Assessment of Vaccines ............ 3 23 Jayanthi J. Wolf, Lisa M. Plitnick, and Danuta J. Herzyk 17 Safety Challenges Facing Next Generation Vaccines and the Role for Biomarkers .................................................................. 351 S. Sohail Ahmed, Ernesto Oviedo- Orta, and Jeffrey Ulm er Index ................................................................................................................. 365 Manmohan Singh Editor Novel Immune Potentiators and for Next Generation Vaccines Development of new-generation vaccines is now more challenging than ever, as identifying^ purifying and evaluating vaccine antigens is a complex undertaking- Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations — many of which will be nanoparticulates — can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. This book outlines all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts ід the area of vaccine formulation äad delivery systems tie in what is the most current status, Hicluidiag clioicaJ evaluations with these novel vaccine technologies.
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spelling Novel immune potentiators and delivery technologies for next generation vaccines Manmohan Singh, ed.
New York [u.a.] Springer 2013
X, 369 S. Ill., graph. Darst.
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nc rdacarrier
Medizin
Medicine
Immunology
Microbiology
Vaccines
Pharmaceutical technology
Impfstoff (DE-588)4026655-2 gnd rswk-swf
Forschung (DE-588)4017894-8 gnd rswk-swf
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Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027676217&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027676217&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext
spellingShingle Novel immune potentiators and delivery technologies for next generation vaccines
Medizin
Medicine
Immunology
Microbiology
Vaccines
Pharmaceutical technology
Impfstoff (DE-588)4026655-2 gnd
Forschung (DE-588)4017894-8 gnd
subject_GND (DE-588)4026655-2
(DE-588)4017894-8
(DE-588)4143413-4
title Novel immune potentiators and delivery technologies for next generation vaccines
title_auth Novel immune potentiators and delivery technologies for next generation vaccines
title_exact_search Novel immune potentiators and delivery technologies for next generation vaccines
title_full Novel immune potentiators and delivery technologies for next generation vaccines Manmohan Singh, ed.
title_fullStr Novel immune potentiators and delivery technologies for next generation vaccines Manmohan Singh, ed.
title_full_unstemmed Novel immune potentiators and delivery technologies for next generation vaccines Manmohan Singh, ed.
title_short Novel immune potentiators and delivery technologies for next generation vaccines
title_sort novel immune potentiators and delivery technologies for next generation vaccines
topic Medizin
Medicine
Immunology
Microbiology
Vaccines
Pharmaceutical technology
Impfstoff (DE-588)4026655-2 gnd
Forschung (DE-588)4017894-8 gnd
topic_facet Medizin
Medicine
Immunology
Microbiology
Vaccines
Pharmaceutical technology
Impfstoff
Forschung
Aufsatzsammlung
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