Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide
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Format: | Buch |
Sprache: | English |
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Chichester
Wiley
2013
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Ausgabe: | 2. ed. |
Schriftenreihe: | Inorganic chemistry
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Datensatz im Suchindex
_version_ | 1804150451730382848 |
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adam_text | Titel: Bioinorganic chemistry
Autor: Kaim, Wolfgang
Jahr: 2013
Contents
Preface to the Second Edition xi
Preface to the First Edition xiii
1 Historical Background, Current Relevance and Perspectives 1
References 6
2 Some General Principles 7
2.1 Occurrence and Availability of Inorganic Elements in Organisms 7
Insertion: The Chelate Effect 14
Insertion: Hard and Soft Coordination Centers 14
2.2 Biological Functions of Inorganic Elements 14
2.3 Biological Ligands for Metal Ions 16
2.3.1 Coordination by Proteins-Comments on Enzymatic Catalysis 17
Insertion: The Entatic State in Enzymatic Catalysis 20
2.3.2 Tetrapyrrole Ligands and Other Macrocycles 22
Insertion: Electron Spin States in Transition Metal Ions 28
2.3.3 Nucleobases, Nucleotides and Nucleic Acids (RNA, DNA) as Ligands .... 31
Insertion: Secondary Bonding 32
2.4 Relevance of Model Compounds 34
References 34
3 Cobalamins, Including Vitamin and Coenzyme Bi2 37
3.1 History and Structural Characterization 37
Insertion: Bioorganometallics I 38
3.2 General Reactions of Alkylcobalamins 41
3.2.1 One-electron Reduction and Oxidation 41
3.2.2 Co-C Bond Cleavage 42
Insertion: Electron Paramagnetic Resonance I 43
3.3 Enzyme Functions of Cobalamins 45
3.3.1 Adenosylcobalamin (AdoCbl)-dependent Isomerases 45
Insertion: Organic Redox Coenzymes 48
3.3.2 Alkylation Reactions of Methylcobalamin (MeCbl)-dependent Alkyl
Transferases 51
3.4 Model Systems and the Enzymatic Activation of the Co-C Bond 52
References 53
4 Metals at the Center of Photosynthesis: Magnesium and Manganese 57
4.1 Volume and Efficiency of Photosynthesis 57
4.2 Primary Processes in Photosynthesis 59
vi
Contents
4.2.1 Light Absorption (Energy Acquisition)
4.2.2 Exciton Transport (Directed Energy Transfer)
4.2.3 Charge Separation and Electron Transport
Insertion: Structure Determination by X-ray Diffraction
4.3 Manganese-catalyzed Oxidation of Water to 02
Insertion: Spin-Spin Coupling
References
5 The Dioxygen Molecule, 02: Uptake, Transport and Storage of an Inorganic
Natural Product
5.1 Molecular and Chemical Properties of Dioxygen, 02
5.2 Oxygen Transport and Storage through Hemoglobin and Myoglobin -
5.3 Alternative Oxygen Transport in Some Lower Animals: Hemerythrin and Hemocyanin
5.3.1 Magnetism
5.3.2 Light Absorption
5.3.3 Vibrational Spectroscopy
Insertion: Resonance Raman Spectroscopy
5.3.4 Mössbauer Spectroscopy
Insertion: Mössbauer Spectroscopy
5.3.5 Structure
5.4 Conclusion
References
6 Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism
of Inorganic Intermediates
6.1 Cytochromes
6.2 Cytochrome P-450: Oxygen Transfer from 02 to Nonactivated Substrates
6.3 Peroxidases: Detoxification and Utilization of Doubly Reduced Dioxygen
6.4 Controlling the Reaction Mechanism of the Oxyheme Group: Generation
and Function of Organic Free Radicals
6.5 Hemoproteins in the Catalytic Transformation of Partially Reduced Nitrogen
and Sulfur Compounds
Insertion: Gasotransmitiers
References
7 Iron-Sulfur and Other Non-heme Iron Proteins
7.1 Biological Relevance of the Element Combination Iron—Sulfur
Insertion: Extremophiles and Bioinorganic Chemistry
7.2 Rubredoxins
7.3 [2Fe-2S] Centers
7.4 Polynuclear Fe/S Clusters: Relevance of the Protein Environment and Catalytic Activity
7.5 Model Systems for Fe/S Proteins
7.6 Iron-containing Enzymes without Porphyrin or Sulfide Ligands
7.6.1 Iron-containing Ribonucleotide Reductase
7.6.2 Soluble Methane Monooxygenase
7.6.3 Purple Acid Phosphatases (Fe/Fe and Fe/Zn)
7.6.4 Mononuclear Non-heme Iron Enzymes
References
59
59
62
65
67
73
74
77
77
82
92
92
93
93
93
94
94
95
96
96
99
101
103
108
110
112
113
114
117
117
118
122
122
123
128
130
130
132
133
133
135
Contents víi
8 Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron 139
Insertion: Metallome 139
8.1 The Problem of Iron Mobilization: Oxidation States, Solubility and Medical Relevance 140
8.2 Siderophores: Iron Uptake by Microorganisms 141
Insertion: Optical Isomerism in Octahedral Complexes 144
8.3 Phytosiderophores: Iron Uptake by Plants 149
8.4 Transport and Storage of Iron 150
8.4.1 Transferrin 152
8.4.2 Ferritin 155
8.4.3 Hemosiderin 159
References 160
9 Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal . . 163
9.1 Overview 163
9.2 Urease 164
9.3 Hydrogenases 166
9.4 CO Dehydrogenase = CO Oxidoreductase = Acetyl-CoA Synthase 169
9.5 Methyl-coenzyme M Reductase (Including the F430 Cofactor) 172
Insertion: Natural and Artificial (Industrial) Q Chemistry 174
Insertion: Bioorganometallics II: The Organometallic Chemistry of Cobalt and Nickel . 176
9.6 Superoxide Dismutase 177
9.7 Model Compounds 178
Further Reading 178
References 179
10 Copper-containing Proteins: An Alternative to Biological Iron 183
10.1 Type 1: Blue Copper Proteins 186
Insertion: Electron Paramagnetic Resonance II 187
10.2 Type 2 and Type 3 Copper Centers in 02-activating Proteins: Oxygen Transport
and Oxygenation 191
10.3 Copper Proteins as Oxidases/Reductases 195
10.4 Cytochrome c Oxidase 200
10.5 Cu,Zn-and Other Superoxide Dismutases: Substrate-specific Antioxidants 203
References 207
11 Biological Functions of the Early Transition Metals: Molybdenum, Tungsten,
Vanadium and Chromium 211
11.1 Oxygen Transfer through Tungsten- and Molybdenum-containing Enzymes 211
11.1.1 Overview 211
11.1.2 Oxotransferase Enzymes Containing the Molybdopterin or
Tungstopterin Cofactor 213
Insertion: Oxidation 214
11.2 Metalloenzymes in the Biological Nitrogen Cycle: Molybdenum-dependent
Nitrogen Fixation 219
11.3 Alternative Nitrogenases 226
11.4 Biological Vanadium Outside of Nitrogenases 229
11.5 Chromium(III) in the Metabolism? 231
References 232
viii
Contents
12 Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of
Hydrolysis and Condensation Reactions
12.1 Overview
12.2 Carboanhydrase
12.3 Carboxypeptidase A and Other Hydrolases
12.4 Catalysis of Condensation Reactions by Zinc-containing Enzymes
12.5 Alcohol Dehydrogenase and Related Enzymes
12.6 The Zinc Finger and Other Gene-regulatory Zinc Proteins
12.7 Insulin, hGH, Metallothionein and DNA Repair Systems as Zinc-containing Proteins .
References
13 Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth
Metal Cations
13.1 Characterization and Biological Roles of K+, Na+, Ca2+ and Mg2+
Insertion: Heteroatom Nuclear Magnetic Resonance
13.2 Complexes of Alkali and Alkaline Earth Metal Ions with Macrocycles
13.3 Ion Channels
13.4 Ion Pumps
Further Reading
References
14 Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions
Mg2+ and Ca2+
14.1 Magnesium: Catalysis of Phosphate Transfer by Divalent Ions
14.2 The Ubiquitous Regulatory Role of Ca2+
Further Reading
References
15 Biomineralization: The Controlled Assembly of Advanced Materials in Biology ....
15.1 Overview
15.2 Nucleation and Crystal Growth
Insertion: Dimensions
15.3 Examples of Biominerals
15.3.1 Calcium Phosphate in the Bones of Vertebrates and the Global P Cycle . . . -
Insertion: The Global P Cycle
15.3.2 Calcium Carbonate and the Global Inorganic C Cycle
Insertion: The Global C Cycle and the Marine Inorganic C Cycle
15.3.3 Amorphous Silica
15.3.4 Iron Biominerals
15.3.5 Strontium and Barium Sulfates
15.4 Biomimetic Materials
Further Reading
References
16 Biological Functions of the Nonmetallic Inorganic Elements
16.1 Overview
16.2 Boron
16.3 Silicon
235
235
238
243
248
249
251
253
254
257
257
262
264
267
270
273
273
277
277
283
291
291
295
295
299
300
301
301
305
306
307
308
309
310
310
311
311
315
315
315
315
Contents ix
16.4 Arsenic and Trivalent Phosphorus 316
16.5 Bromine 317
16.6 Fluorine 317
16.7 Iodine 318
16.8 Selenium 320
References 325
17 The Bioinorganic Chemistry of the Quintessentially Toxic Metals 327
17.1 Overview 327
17.2 Lead 329
17.3 Cadmium 332
17.4 Thallium 334
17.5 Mercury 335
17.6 Aluminum 340
17.7 Beryllium 342
17.8 Chromium and Tungsten 343
17.9 Toxicity of Nanomaterials 344
Further Reading 345
References 345
18 Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic
Compounds 349
18.1 Radiation Risks and Medical Benefits from Natural and Synthetic Radionuclides . . . 349
18.1.1 The Biochemical Impact of Ionizing Radiation from Radioactive Isotopes . . 349
18.1.2 Natural and Synthetic Radioisotopes 350
18.1.3 Bioinorganic Chemistry of Radionuclides 351
Insertion: Fukushima Daiichi, Chernobyl, Hiroshima and Nuclear Weapons Testing . . 353
18.1.4 Radiopharmaceuticals 356
18.1.5 Technetium: A Synthetic Bioinorganic Element 359
18.1.6 Radiotracers for the Investigation of the Metallome 363
18.2 Medical Imaging Based on Nonradioactive Inorganic Compounds 363
18.2.1 Magnetic Resonance Imaging 363
18.2.2 X-ray Contrast Agents 364
Further Reading 365
References 365
19 Chemotherapy Involving Nonessential Elements 369
19.1 Overview 369
19.2 Platinum Complexes in Cancer Therapy 369
19.2.1 Discovery, Application and Structure-Effect Relationships 369
19.2.2 Cisplatin: Mode of Action 372
19.3 New Anticancer Drugs Based on Transition Metal Complexes 378
19.3.1 Overview and Aims for Drug Development 378
19.3.2 Nonplatinum Anticancer Drugs 379
19.4 Further Inorganic Compounds in (Noncancer) Chemotherapy 383
19.4.1 Gold-containing Drugs Used in the Therapy of Rheumatoid Arthritis 383
19.4.2 Lithium in Psychopharmacologic Drugs 384
19.4.3 Bismuth Compounds against Ulcers 385
X Contents
19.4.4 Vanadium-containing Insulin Mimetics and V-containing Anti-HIV Drugs . . 386
19.4.5 Sodium Nitroprusside 386
19.5 Bioorganometallíc Chemistry of Nonessential Elements 387
Further Reading 389
References 389
Index 393
|
any_adam_object | 1 |
author | Kaim, Wolfgang 1951- Schwederski, Brigitte 1959- Klein, Axel 1967- |
author_GND | (DE-588)130562157 (DE-588)130562173 (DE-588)120678853 |
author_facet | Kaim, Wolfgang 1951- Schwederski, Brigitte 1959- Klein, Axel 1967- |
author_role | aut aut aut |
author_sort | Kaim, Wolfgang 1951- |
author_variant | w k wk b s bs a k ak |
building | Verbundindex |
bvnumber | BV041080584 |
classification_rvk | VH 9750 VH 9751 WD 4750 |
classification_tum | CHE 805f |
ctrlnum | (OCoLC)862796258 (DE-599)BVBBV041080584 |
discipline | Chemie / Pharmazie Biologie Chemie |
edition | 2. ed. |
format | Book |
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genre_facet | Einführung Lehrbuch |
id | DE-604.BV041080584 |
illustrated | Illustrated |
indexdate | 2024-07-10T00:39:08Z |
institution | BVB |
isbn | 9780470975244 9780470975237 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026057386 |
oclc_num | 862796258 |
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physical | XVI, 409 S. Ill., graph. Darst. |
publishDate | 2013 |
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publisher | Wiley |
record_format | marc |
series2 | Inorganic chemistry |
spelling | Kaim, Wolfgang 1951- Verfasser (DE-588)130562157 aut Bioanorganische Chemie Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein 2. ed. Chichester Wiley 2013 XVI, 409 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Inorganic chemistry Hier auch später erschienene, unveränderte Nachdrucke. Bioanorganische Chemie (DE-588)4126727-8 gnd rswk-swf Naturstoffchemie (DE-588)4171332-1 gnd rswk-swf 1\p (DE-588)4151278-9 Einführung gnd-content 2\p (DE-588)4123623-3 Lehrbuch gnd-content Bioanorganische Chemie (DE-588)4126727-8 s DE-604 Naturstoffchemie (DE-588)4171332-1 s 3\p DE-604 Schwederski, Brigitte 1959- Verfasser (DE-588)130562173 aut Klein, Axel 1967- Verfasser (DE-588)120678853 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026057386&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
spellingShingle | Kaim, Wolfgang 1951- Schwederski, Brigitte 1959- Klein, Axel 1967- Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide Bioanorganische Chemie (DE-588)4126727-8 gnd Naturstoffchemie (DE-588)4171332-1 gnd |
subject_GND | (DE-588)4126727-8 (DE-588)4171332-1 (DE-588)4151278-9 (DE-588)4123623-3 |
title | Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide |
title_alt | Bioanorganische Chemie |
title_auth | Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide |
title_exact_search | Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide |
title_full | Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein |
title_fullStr | Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein |
title_full_unstemmed | Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein |
title_short | Bioinorganic chemistry |
title_sort | bioinorganic chemistry inorganic elements in the chemistry of life an introduction and guide |
title_sub | inorganic elements in the chemistry of life ; an introduction and guide |
topic | Bioanorganische Chemie (DE-588)4126727-8 gnd Naturstoffchemie (DE-588)4171332-1 gnd |
topic_facet | Bioanorganische Chemie Naturstoffchemie Einführung Lehrbuch |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026057386&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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