Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide

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Bibliographische Detailangaben
Hauptverfasser: Kaim, Wolfgang 1951- (VerfasserIn), Schwederski, Brigitte 1959- (VerfasserIn), Klein, Axel 1967- (VerfasserIn)
Format: Buch
Sprache:English
Veröffentlicht: Chichester Wiley 2013
Ausgabe:2. ed.
Schriftenreihe:Inorganic chemistry
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Datensatz im Suchindex

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adam_text Titel: Bioinorganic chemistry Autor: Kaim, Wolfgang Jahr: 2013 Contents Preface to the Second Edition xi Preface to the First Edition xiii 1 Historical Background, Current Relevance and Perspectives 1 References 6 2 Some General Principles 7 2.1 Occurrence and Availability of Inorganic Elements in Organisms 7 Insertion: The Chelate Effect 14 Insertion: Hard and Soft Coordination Centers 14 2.2 Biological Functions of Inorganic Elements 14 2.3 Biological Ligands for Metal Ions 16 2.3.1 Coordination by Proteins-Comments on Enzymatic Catalysis 17 Insertion: The Entatic State in Enzymatic Catalysis 20 2.3.2 Tetrapyrrole Ligands and Other Macrocycles 22 Insertion: Electron Spin States in Transition Metal Ions 28 2.3.3 Nucleobases, Nucleotides and Nucleic Acids (RNA, DNA) as Ligands .... 31 Insertion: Secondary Bonding 32 2.4 Relevance of Model Compounds 34 References 34 3 Cobalamins, Including Vitamin and Coenzyme Bi2 37 3.1 History and Structural Characterization 37 Insertion: Bioorganometallics I 38 3.2 General Reactions of Alkylcobalamins 41 3.2.1 One-electron Reduction and Oxidation 41 3.2.2 Co-C Bond Cleavage 42 Insertion: Electron Paramagnetic Resonance I 43 3.3 Enzyme Functions of Cobalamins 45 3.3.1 Adenosylcobalamin (AdoCbl)-dependent Isomerases 45 Insertion: Organic Redox Coenzymes 48 3.3.2 Alkylation Reactions of Methylcobalamin (MeCbl)-dependent Alkyl Transferases 51 3.4 Model Systems and the Enzymatic Activation of the Co-C Bond 52 References 53 4 Metals at the Center of Photosynthesis: Magnesium and Manganese 57 4.1 Volume and Efficiency of Photosynthesis 57 4.2 Primary Processes in Photosynthesis 59 vi Contents 4.2.1 Light Absorption (Energy Acquisition) 4.2.2 Exciton Transport (Directed Energy Transfer) 4.2.3 Charge Separation and Electron Transport Insertion: Structure Determination by X-ray Diffraction 4.3 Manganese-catalyzed Oxidation of Water to 02 Insertion: Spin-Spin Coupling References 5 The Dioxygen Molecule, 02: Uptake, Transport and Storage of an Inorganic Natural Product 5.1 Molecular and Chemical Properties of Dioxygen, 02 5.2 Oxygen Transport and Storage through Hemoglobin and Myoglobin - 5.3 Alternative Oxygen Transport in Some Lower Animals: Hemerythrin and Hemocyanin 5.3.1 Magnetism 5.3.2 Light Absorption 5.3.3 Vibrational Spectroscopy Insertion: Resonance Raman Spectroscopy 5.3.4 Mössbauer Spectroscopy Insertion: Mössbauer Spectroscopy 5.3.5 Structure 5.4 Conclusion References 6 Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism of Inorganic Intermediates 6.1 Cytochromes 6.2 Cytochrome P-450: Oxygen Transfer from 02 to Nonactivated Substrates 6.3 Peroxidases: Detoxification and Utilization of Doubly Reduced Dioxygen 6.4 Controlling the Reaction Mechanism of the Oxyheme Group: Generation and Function of Organic Free Radicals 6.5 Hemoproteins in the Catalytic Transformation of Partially Reduced Nitrogen and Sulfur Compounds Insertion: Gasotransmitiers References 7 Iron-Sulfur and Other Non-heme Iron Proteins 7.1 Biological Relevance of the Element Combination Iron—Sulfur Insertion: Extremophiles and Bioinorganic Chemistry 7.2 Rubredoxins 7.3 [2Fe-2S] Centers 7.4 Polynuclear Fe/S Clusters: Relevance of the Protein Environment and Catalytic Activity 7.5 Model Systems for Fe/S Proteins 7.6 Iron-containing Enzymes without Porphyrin or Sulfide Ligands 7.6.1 Iron-containing Ribonucleotide Reductase 7.6.2 Soluble Methane Monooxygenase 7.6.3 Purple Acid Phosphatases (Fe/Fe and Fe/Zn) 7.6.4 Mononuclear Non-heme Iron Enzymes References 59 59 62 65 67 73 74 77 77 82 92 92 93 93 93 94 94 95 96 96 99 101 103 108 110 112 113 114 117 117 118 122 122 123 128 130 130 132 133 133 135 Contents víi 8 Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron 139 Insertion: Metallome 139 8.1 The Problem of Iron Mobilization: Oxidation States, Solubility and Medical Relevance 140 8.2 Siderophores: Iron Uptake by Microorganisms 141 Insertion: Optical Isomerism in Octahedral Complexes 144 8.3 Phytosiderophores: Iron Uptake by Plants 149 8.4 Transport and Storage of Iron 150 8.4.1 Transferrin 152 8.4.2 Ferritin 155 8.4.3 Hemosiderin 159 References 160 9 Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal . . 163 9.1 Overview 163 9.2 Urease 164 9.3 Hydrogenases 166 9.4 CO Dehydrogenase = CO Oxidoreductase = Acetyl-CoA Synthase 169 9.5 Methyl-coenzyme M Reductase (Including the F430 Cofactor) 172 Insertion: Natural and Artificial (Industrial) Q Chemistry 174 Insertion: Bioorganometallics II: The Organometallic Chemistry of Cobalt and Nickel . 176 9.6 Superoxide Dismutase 177 9.7 Model Compounds 178 Further Reading 178 References 179 10 Copper-containing Proteins: An Alternative to Biological Iron 183 10.1 Type 1: Blue Copper Proteins 186 Insertion: Electron Paramagnetic Resonance II 187 10.2 Type 2 and Type 3 Copper Centers in 02-activating Proteins: Oxygen Transport and Oxygenation 191 10.3 Copper Proteins as Oxidases/Reductases 195 10.4 Cytochrome c Oxidase 200 10.5 Cu,Zn-and Other Superoxide Dismutases: Substrate-specific Antioxidants 203 References 207 11 Biological Functions of the Early Transition Metals: Molybdenum, Tungsten, Vanadium and Chromium 211 11.1 Oxygen Transfer through Tungsten- and Molybdenum-containing Enzymes 211 11.1.1 Overview 211 11.1.2 Oxotransferase Enzymes Containing the Molybdopterin or Tungstopterin Cofactor 213 Insertion: Oxidation 214 11.2 Metalloenzymes in the Biological Nitrogen Cycle: Molybdenum-dependent Nitrogen Fixation 219 11.3 Alternative Nitrogenases 226 11.4 Biological Vanadium Outside of Nitrogenases 229 11.5 Chromium(III) in the Metabolism? 231 References 232 viii Contents 12 Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of Hydrolysis and Condensation Reactions 12.1 Overview 12.2 Carboanhydrase 12.3 Carboxypeptidase A and Other Hydrolases 12.4 Catalysis of Condensation Reactions by Zinc-containing Enzymes 12.5 Alcohol Dehydrogenase and Related Enzymes 12.6 The Zinc Finger and Other Gene-regulatory Zinc Proteins 12.7 Insulin, hGH, Metallothionein and DNA Repair Systems as Zinc-containing Proteins . References 13 Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth Metal Cations 13.1 Characterization and Biological Roles of K+, Na+, Ca2+ and Mg2+ Insertion: Heteroatom Nuclear Magnetic Resonance 13.2 Complexes of Alkali and Alkaline Earth Metal Ions with Macrocycles 13.3 Ion Channels 13.4 Ion Pumps Further Reading References 14 Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions Mg2+ and Ca2+ 14.1 Magnesium: Catalysis of Phosphate Transfer by Divalent Ions 14.2 The Ubiquitous Regulatory Role of Ca2+ Further Reading References 15 Biomineralization: The Controlled Assembly of Advanced Materials in Biology .... 15.1 Overview 15.2 Nucleation and Crystal Growth Insertion: Dimensions 15.3 Examples of Biominerals 15.3.1 Calcium Phosphate in the Bones of Vertebrates and the Global P Cycle . . . - Insertion: The Global P Cycle 15.3.2 Calcium Carbonate and the Global Inorganic C Cycle Insertion: The Global C Cycle and the Marine Inorganic C Cycle 15.3.3 Amorphous Silica 15.3.4 Iron Biominerals 15.3.5 Strontium and Barium Sulfates 15.4 Biomimetic Materials Further Reading References 16 Biological Functions of the Nonmetallic Inorganic Elements 16.1 Overview 16.2 Boron 16.3 Silicon 235 235 238 243 248 249 251 253 254 257 257 262 264 267 270 273 273 277 277 283 291 291 295 295 299 300 301 301 305 306 307 308 309 310 310 311 311 315 315 315 315 Contents ix 16.4 Arsenic and Trivalent Phosphorus 316 16.5 Bromine 317 16.6 Fluorine 317 16.7 Iodine 318 16.8 Selenium 320 References 325 17 The Bioinorganic Chemistry of the Quintessentially Toxic Metals 327 17.1 Overview 327 17.2 Lead 329 17.3 Cadmium 332 17.4 Thallium 334 17.5 Mercury 335 17.6 Aluminum 340 17.7 Beryllium 342 17.8 Chromium and Tungsten 343 17.9 Toxicity of Nanomaterials 344 Further Reading 345 References 345 18 Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic Compounds 349 18.1 Radiation Risks and Medical Benefits from Natural and Synthetic Radionuclides . . . 349 18.1.1 The Biochemical Impact of Ionizing Radiation from Radioactive Isotopes . . 349 18.1.2 Natural and Synthetic Radioisotopes 350 18.1.3 Bioinorganic Chemistry of Radionuclides 351 Insertion: Fukushima Daiichi, Chernobyl, Hiroshima and Nuclear Weapons Testing . . 353 18.1.4 Radiopharmaceuticals 356 18.1.5 Technetium: A Synthetic Bioinorganic Element 359 18.1.6 Radiotracers for the Investigation of the Metallome 363 18.2 Medical Imaging Based on Nonradioactive Inorganic Compounds 363 18.2.1 Magnetic Resonance Imaging 363 18.2.2 X-ray Contrast Agents 364 Further Reading 365 References 365 19 Chemotherapy Involving Nonessential Elements 369 19.1 Overview 369 19.2 Platinum Complexes in Cancer Therapy 369 19.2.1 Discovery, Application and Structure-Effect Relationships 369 19.2.2 Cisplatin: Mode of Action 372 19.3 New Anticancer Drugs Based on Transition Metal Complexes 378 19.3.1 Overview and Aims for Drug Development 378 19.3.2 Nonplatinum Anticancer Drugs 379 19.4 Further Inorganic Compounds in (Noncancer) Chemotherapy 383 19.4.1 Gold-containing Drugs Used in the Therapy of Rheumatoid Arthritis 383 19.4.2 Lithium in Psychopharmacologic Drugs 384 19.4.3 Bismuth Compounds against Ulcers 385 X Contents 19.4.4 Vanadium-containing Insulin Mimetics and V-containing Anti-HIV Drugs . . 386 19.4.5 Sodium Nitroprusside 386 19.5 Bioorganometallíc Chemistry of Nonessential Elements 387 Further Reading 389 References 389 Index 393
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Bioanorganische Chemie
Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein
2. ed.
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spellingShingle Kaim, Wolfgang 1951-
Schwederski, Brigitte 1959-
Klein, Axel 1967-
Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide
Bioanorganische Chemie (DE-588)4126727-8 gnd
Naturstoffchemie (DE-588)4171332-1 gnd
subject_GND (DE-588)4126727-8
(DE-588)4171332-1
(DE-588)4151278-9
(DE-588)4123623-3
title Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide
title_alt Bioanorganische Chemie
title_auth Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide
title_exact_search Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide
title_full Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein
title_fullStr Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein
title_full_unstemmed Bioinorganic chemistry inorganic elements in the chemistry of life ; an introduction and guide written and translated by Wolfgang Kaim ; Brigitte Schwederski ; Axel Klein
title_short Bioinorganic chemistry
title_sort bioinorganic chemistry inorganic elements in the chemistry of life an introduction and guide
title_sub inorganic elements in the chemistry of life ; an introduction and guide
topic Bioanorganische Chemie (DE-588)4126727-8 gnd
Naturstoffchemie (DE-588)4171332-1 gnd
topic_facet Bioanorganische Chemie
Naturstoffchemie
Einführung
Lehrbuch
url http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026057386&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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