Molecular genetics of bacteria Larry Snyder ...
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| 020 | |a 1555816274 |9 1-55581-627-4 | ||
| 020 | |a 9781555816278 |9 978-1-55581-627-8 | ||
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| 245 | 1 | 0 | |a Molecular genetics of bacteria |b Larry Snyder ... |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a Washington, DC |b ASM Press |c 2013 | |
| 300 | |a XX, 707 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a 3. Aufl. u.d.T.: Snyder, Larry: Molecular genetics of bacteria | ||
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| 700 | 1 | |a Snyder, Larry |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-1-55581-716-9 |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025306442&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-025306442 | ||
Datensatz im Suchindex
| DE-BY-TUM_call_number | 0303/BIO 180f 2011 L 37(4)+2 1003/BIO 180f 2005 L 715(4)+4 1003/BIO 180f 2005 L 715(4)+2 1003/BIO 180f 2005 L 715(4)+3 1004/BIO 180f 2005 B 2252(4) 0303/BIO 180f 2011 L 37(4) 1003/BIO 180f 2005 L 715(4)+10 1003/BIO 180f 2005 L 715(4)+8 0303/BIO 180f 2011 L 37(4)+5 1003/BIO 180f 2005 L 715(4)+9 1003/BIO 180f 2005 L 715(4)+6 1003/BIO 180f 2005 L 715(4)+5 0303/BIO 180f 2011 L 37(4)+4 0303/BIO 180f 2011 L 37(4)+3 1003/BIO 180f 2005 L 715(4) 0304/BIO 180f 2010 B 636(4) 1003/BIO 180f 2005 L 715(4)+7 |
|---|---|
| DE-BY-TUM_katkey | 2000970 |
| DE-BY-TUM_media_number | 040008523302 040008232946 040008523277 040080119542 040008232979 040080119531 040008232968 040080119564 040008232957 040008232991 040008232980 040008523299 040080119520 040008523313 040080119553 040080119575 040008523288 |
| _version_ | 1816713951573966848 |
| adam_text | Contents
Preface
xv
About the Authors
xix
Introduction
1
The Biological Universe
3
The Bacteria
3
The Archaea
3
The Eukaryotes
5
Speculations on the Origin of the Three Domains of Life
5
What Is Genetics?
6
Bacterial Genetics
6
Bacteria Are Haploid
7
Short Generation Times
7
Asexual Reproduction
7
Colony Growth on
Agar
Plates
7
Colony Purification
7
Serial Dilutions
7
Selections
8
Storing Stocks of Bacterial Strains
8
Genetic Exchange
8
Phage Genetics
8
Phages Are Haploid
8
Selections with Phages
9
Crosses with Phages
9
vi
CONTENTS
A
Brief History of Bacterial Molecular
Genetics
9
Inheritance in Bacteria
9
Transformation
9
Conjugation
10
Transduction
10
Recombination within Genes
10
Semiconservative
DNA
Replication
10
mRNA
10
The Genetic Code
10
The
Operan
Model
10
Enzymes for Molecular Biology
10
What Is Ahead
11
SUGGESTED READING
11
CHAPTER
1____________________
The Bacterial Chromosome:
DNA
Structure, Replication, and
Segregation
13
DNA
Structure
13
The Deoxyribonucleotides
13
The
DNA
Chain
14
The
5
and 3 Ends
14
Base Pairing
16
Antiparallel
Construction
17
The Major and Minor Grooves
17
The Mechanism of
DNA
Replication
17
Deoxyribonucleotide Precursor Synthesis
17
Replication of the Bacterial Chromosome
19
Replication of Double-Stranded
DNA 23
26
Replication Errors
Editing
26
RNA
Primers and Editing
27
Impediments to
DNA
Replication
28
Damaged
DNA
and
DNA Polymerase
ill
28
Mechanisms To Deal with Impediments on Template
DNA
Strands
28
Physical Blocks to Replication Forks
30
Replication of the Bacterial Chromosome and
Cell Division
31
Structure of the Bacterial Chromosome
31
Replication of the Bacterial Chromosome
31
Initiation of Chromosome Replication
32
RNA
Priming of Initiation
33
Termination of Chromosome Replication
33
Chromosome Segregation
34
Coordination of Cell Division with Replication of the
Chromosome
43
Timing of Initiation of Replication
45
The Bacterial Nucleoid
47
Supercoiling in the Nucleoid
47
Topoisomerases
49
The Bacterial Genome
50
Antibiotics That Affect Replication and
DNA
Structure
51
Antibiotics That Block Precursor Synthesis
51
Antibiotics That Block Polymerization of
Deoxynucleotides
52
Antibiotics That Affect
DNA
Structure
52
Antibiotics That Affect Gyrase
52
Molecular Biology Manipulations with
DNA 53
Restriction Endonucleases
53
Hybridizations
56
Applications of the Enzymes Used in
DNA
Replication
58
Polymerase Chain Reaction
58
BOX
1.1
Structural Features of Bacterial
Genomes
37
BOX
1.2
Advanced Genome-Sequencing
Techniques
59
SUMMARY
62
QUESTIONS FOR THOUGHT
64
PROBLEMS
64
SUGGESTED READING
65
CHAPTER
2
Bacterial Gene Expression:
Transcription, Translation, and Protein
Folding
67
Overview
67
The Structure and Function of
RNA
Types of
RNA
69
RNA
Precursors
69
RNA
Structure
69
RNA
Processing and Modification
70
68
CONTENTS
vii
Transcription
70
Structure
of Bacterial
RNA Polymerase
70
Overview of Transcription
71
Details of Transcription
75
rRNAs and tRNAs
81
RNA
Degradation
82
RNases
83
The Structure and Function of Proteins
84
Protein Structure
85
Translation
86
Structure of the Bacterial Ribosome
86
Overview of Translation
88
Details of Protein Synthesis
90
The Genetic Code
97
Protein Folding and Degradation
105
Protein Chaperones
105
Protein Degradation
107
Membrane Proteins and Protein
Export
108
Regulation of Gene Expression
108
Transcriptional Regulation
108
Posttranscriptional Regulation
109
Genomes and Genomics
109
Annotation and Comparative Genomics
110
What You Need To Know
110
Open Reading Frames
116
Transcriptional and Translational Fusions
116
Antibiotics That Block Transcription and
Translation
116
Antibiotic Inhibitors of Transcription
117
Antibiotic Inhibitors of Translation
118
BOX
2.1
Molecular Phytogeny
82
BOX
2.2
Mimicry in Translation
96
BOX
23
Exceptions to the Code
99
BOX
2.4
Selfish DNAs:
RNA Introns
and Protein
Inteins
102
BOX
2.5
Annotation and Comparative
Genomics
110
SUMMARY
120
QUESTIONS FOR THOUGHT
122
PROBLEMS
122
SUGGESTED READING
123
CHAPTER
3
Bacterial Genetic Analysis:
Fundamentals and Current
Approaches
125
Definitions
125
Terms Used in Genetics
125
Genetic Names
126
Auxotrophic and Catabolic Mutants
127
Conditional-Lethal Mutants
128
Resistant Mutants
130
Inheritance in Bacteria
130
The Luria and Delbriick Experiment
131
Mutants Are Clonal
132
The
Lederbergs
Experiment
133
Mutation Rates
133
Calculating Mutation Rates
135
Calculating the Mutation Rate from the Rate of
Increase in the Proportion of Mutants
136
Types of Mutations
137
Properties of Mutations
138
Base Pair Changes
138
Frameshift Mutations
142
Deletion Mutations
144
Tandem-Duplication Mutations
145
Inversion Mutations
147
Insertion Mutations
148
Reversion versus Suppression
149
Intragenic Suppressors
149
Intergenic Suppressors
150
Genetic Analysis in Bacteria
153
Isolating Mutants
153
Genetic Characterization of Mutants
157
Complementation Tests
161
Genetic Crosses in Bacteria
167
Mapping of Bacterial Markers by Transduction and
Transformation
168
Other Uses of Transformation and
Transduction
172
Genetic Mapping by Hfr Crosses
173
Isolation of Tandem Duplications of the his
Operon ¡n Salmonella
176
Lengths of Tandem Duplications
178
Frequency of Spontaneous Duplications
179
viii
CONTENTS
BOX
3.1
Statistical Analysis of the Number of Mutants
per Culture
134
BOX
3.2
Inversions and the Genetic Map
148
SUMMARY
179
QUESTIONS FOR THOUGHT
181
PROBLEMS
181
SUGGESTED READING
182
CHAPTER
4
Plasmids
183
What Is
a Plasmici?
183
Naming Plasmids
184
Functions Encoded by Plasmids
184
Plasmid Structure
185
Properties of Plasmids
186
Replication
186
Functions of the
ori
Region
189
Plasmid Replication Control Mechanisms
194
Mechanisms To Prevent Curing of Plasmids
203
The Par Systems of Plasmids
205
Plasmid Cloning Vectors
209
Examples of Plasmid Cloning Vectors
210
Broad-Host-Range Cloning Vectors
213
BOX
4.1
Linear Chromosomes and Plasmids in
Bacteria
190
BOX
4.2
Toxin-Antitoxin Systems and Plasmid
Maintenance
204
SUMMARY
216
QUESTIONS FOR THOUGHT
217
PROBLEMS
217
SUGGESTED READING
217
CHAPTER
5
Conjugation
219
Overview
219
Classification of Self-Transmissible Plasmids
220
The Fertility Plasmid
220
Mechanism of
DNA
Transfer during
Conjugation in Gram-Negative Bacteria
221
Transfer
(ira)
Genes
221
The oriT Sequence
225
Male-Specific Phages
226
Efficiency of Transfer
227
Interspecies
Transfer of Plasmids
227
Conjugation and Type IV Protein Secretion
228
Mobiiizable Plasmids
232
Chromosome Transfer by Plasmids
235
Formation of Hfr Strains
235
Transfer of Chromosomal
DNA
by Integrated
Plasmids
236
Chromosome Mobilization
Prime Factors
236
236
Transfer Systems of Gram-Positive
Bacteria
237
Plasmid-Attracting Pheromones
237
Integrating Conjugative Elements
240
BOX
5.1
Gene Exchange between Domains
230
SUMMARY
242
QUESTIONS FOR THOUGHT
243
PROBLEMS
243
SUGGESTED READING
244
CHAPTER
6
Transformation
247
Natural Transformation
248
Discovery of Transformation
248
Competence
248
DNA
Processing after Uptake
252
Experimental Evidence for Models of Natural
Transformation
252
Plasmid Transformation and Phage Transfection of
Naturally Competent Bacteria
254
Regulation of Natural Competence
255
Role of Natural Transformation
257
Importance of Natural Transformation for
Forward and Reverse Genetics
259
Congression
259
Artificially Induced Competence
260
Chemical Induction
260
Electroporation
261
Protoplast Transformation
261
BOX
6.1
Antigenic Variation in Neisseria
gonorrhoeae
259
SUMMARY
262
CONTENTS
¡χ
QUESTIONS
FOR THOUGHT
262
PROBLEMS
262
SUGGESTED READING
263
CHAPTER
7
Bacteriophages: Lytic Development,
Genetics, and Generalized
Transduction
265
Regulation of Gene Expression during Lytic
Development
270
Phages That Encode Their Own
RNA Polymerases
272
17
Phage-Based Expression Vectors
273
Making Riboprobes and RNA-Processing
Substrates
273
Phage T4: Transcriptional Activators, a New Sigma
Factor, and Replication-Coupled Transcription
275
Phage
DNA Genome
Replication and
Packaging
279
Phages with Single-Stranded Circular
DNA 279
Replication and
DNA
Packaging: Linear Genomes
285
Phage T7: Linear
DNA
That Forms Concatemers
285
Phage T4: Another Phage That Forms
Concatemers
286
Phage Lysis
289
Single-Protein Lysis
289
Timed Lysis
290
Timing of Lysis by Holins
290
Phage Display
292
Genetic Analysis of Phages
298
Infection of Cells
298
Phage Crosses
299
Recombination and Complementation Tests with
Phages
299
Genetic Experiments with the rll Genes of
Phage T4
301
Constructing the Genetic-Linkage Map of a
Phage
307
Phage Defense Mechanisms
309
Restriction-Modification Systems
310
Abi
Systems
310
CRISPRLoci
311
Generalized Transduction
314
What Makes a Transducing Phage?
315
Shuttle Phasmids
316
Role of Transduction in Bacterial
Evolution
317
BOX
7.1
Phage Genomics
268
BOX
7.2
RNA
Phages
271
BOX
73
Protein Priming
286
BOX
7.4
Phage Display
294
SUMMARY
318
QUESTIONS FOR THOUGHT
319
PROBLEMS
319
SUGGESTED READING
320
CHAPTER
8
Lysogeny: the
λ
Paradigm and the Role
of Lysogenic Conversion in Bacterial
Pathogenesis
323
Phage
λ
324
λ
Lytic Development
324
Replication of
λ
DNA 331
Lysogeny by Phage
λ
333
The Lytic-versus-Lysogen Decision: the Roles of d, dl,
and clll Gene Products
333
Phage
λ
Integration
334
Maintenance of
λ
Lysogeny
335
Immunity to
Superinfection
337
Induction of
λ
338
Summary of the Lytic and Lysogenic Cycles
340
Specialized Transduction
340
Selection of
Η
FT Particles
342
Other Lysogen-Forming Phages
343
Phage P2
343
Phage P4: a Satellite Virus
343
Prophages That Replicate as Plasmids
345
Phage Mu: a Transposon Masquerading as a
Phage
345
Lysogenic Conversion and Bacterial
Pathogenesis
345
E. coli
and Dysentery: Shiga Toxins
346
Diphtheria
347
Cholera
347
S. aureus and Toxic Shock Syndrome
349
Synopsis
350
CONTENTS
Uses of Lysogeny in Genetic Analysis and
Biotechnology
350
Complementation and Gene Expression Studies
350
Use of Phage Display and Frequency of Mixed
Dilysogens To Detect Protein-Protein Interactions
350
Genetic Experiments with Phage
λ
351
Genetic Analysis of
λ
Lysogen Formation
351
Genetics of the
Cl Repressor:
Evidence for the Domain
Structure of Proteins
353
Identification of
λ
nut Sites Involved in Progressive
Transcription Antitermination
354
Isolation of Host
nus
Mutations:
E. coli
Functions
Involved in Transcription Elongation-Termination
356
BOX
8.1
Effects of Prophage Insertion on the
Host
336
SUMMARY
357
QUESTIONS FOR THOUGHT
358
PROBLEMS
358
SUGGESTED READING
359
CHAPTER
9
Transposition, Site-Specific
Recombination, and Families of
Recombinases
361
Transposition
361
Overview of Transposition
362
Structure of Bacterial
Transposons
362
Types of Bacterial
Transposons
364
Assays of Transposition
366
Mechanisms of Transposition
368
Genetic Requirements for Transposition of
Tn3
368
A Molecular Model for Transposition of
Tn3
372
Transposition by Tn
/ 0
and Tn5
373
Details of Transposition by the DDE
Transposons
376
Details of the Mechanism of Transposition by Tn5 and
Tn7
376
Rolling-Circle
Transposons
378
Y
and
S Transposons
378
General Properties of
Transposons
379
Target Site Specificity
379
Effects on Genes Adjacent to the Insertion Site
380
Regulation of Transposition
380
Target Immunity
381
Transposon Mutagenesis
382
Transposon Mutagenesis In Vivo
382
Transposon Mutagenesis In Vitro
382
Transposon Mutagenesis of Plasmids
385
Transposon Mutagenesis of the Bacterial
Chromosome
386
Transposon Mutagenesis of All Bacteria
386
Using Transposon Mutagenesis To Make Random Gene
Fusions
387
Site-Specific Recombination
387
Integrases
387
Resolvases
390
DNA Invertases 391
Y
and
S
Recombinases
392
Y
Recombinases: Mechanism
392
S
Recombinases: Mechanism
397
Importance of Transposition and Site-Specific
Recombination in Bacterial Adaptation
398
BOX
9.1
Transposons
and Genomics
383
SUMMARY
399
QUESTIONS FOR THOUGHT
400
PROBLEMS
400
SUGGESTED READING
401
CHAPTER
10
Molecular Mechanisms of Homologous
Recombination
403
Homologous Recombination and
DNA
Replication in Bacteria
404
Early Evidence for the Interdependence
of Homologous Recombination and
DNA
Replication
404
The Molecular Basis for Recombination in
E.coli
405
Chi
(χ)
Sites and the RecBCD Complex
405
The RecF Pathway
409
Synapse Formation and the RecA Protein
411
The Ruv and RecG Proteins and the Migration and
Cutting of Holliday Junctions
414
CONTENTS
xi
Recombination between Different DNAs in
Bacteria
416
How Are Linear
DNA
Fragments Recombined into the
E. coli
Chromosome?
417
Phage Recombination Pathways
417
Rec
Proteins of Phages T4 and T7
417
The RecE Pathway of the
rac
Prophage
417
The Phage
λ
Red System
419
Recombineering: Gene Replacements in
£.
coli
with Phage
λ
Recombination Functions
419
Genetic Analysis of Recombination in
Bacteria
422
Isolating Rec~ Mutants of
E. coli
422
Isolating Mutants with Mutations in Other
Recombination Genes
423
Gene Conversion and Other Manifestations of
Heteroduplex Formation during Recombination
426
BOX
10.1
Other Types of Double-Strand Break Repair
in Bacteria
410
BOX
10.2
Breaking and Entering:
Introns
and
Inteins Move by Double-Strand Break Repair or
Retrohoming
425
SUMMARY
429
QUESTIONS FOR THOUGHT
430
PROBLEMS
430
SUGGESTED READING
431
CHAPTER
Π
DNA
Repair and
Mutagenesís
433
Evidence for
DNA
Repair
434
Specific Repair Pathways
435
Deamination of Bases
435
Damage Due to Reactive Oxygen
438
Damage Due to Alkylating Agents
441
Damage Due to UV Irradiation
443
General Repair Mechanisms
445
Base Analogs
445
Frameshift
Mutagens
445
Methyl-Directed Mismatch Repair
445
Nucleotide Excision Repair
452
DNA
Damage Tolerance Mechanisms
453
Homologous Recombination and
DNA
Replication
454
SOS-lnducible Repair
458
Mechanism of TLS by the Pol V Mutasome
463
Other Specialized Polymerases and Their
Regulation
464
Summary of Repair Pathways in
f
.
coli
466
Bacteriophage Repair Pathways
466
BOX
11.1
The Role of Reactive Oxygen Species in
Cancer and Degenerative Diseases
439
BOX
11.2 DNA
Repair and Cancer
449
BOX
11.3
The Ames Test
465
SUMMARY
468
QUESTIONS FOR THOUGHT
469
PROBLEMS
469
SUGGESTED READING
469
CHAPTER
12
Regulation of Gene Expression: Genes
and
Opérons
471
Transcriptional Regulation in Bacteria
472
Genetic Evidence for Negative and Positive
Regulation
474
Negative Regulation of Transcription
Initiation
474
Negative Inducible Systems
474
Negative Repressible Systems
484
Molecular Mechanisms of Transcriptional
Repression
486
Positive Regulation of Transcription
Initiation
487
Positive Inducible Systems
487
Positive Repressible Systems
496
Molecular Mechanisms of Transcriptional
Activation
496
Regulation by Transcription Attenuation
497
Modulation of
RNA
Structure
497
Changes in Processivity of
RNA Polymerase
506
Regulation of mRNA Degradation
507
Protein-Dependent Effects on
RNA
Stability
507
RNA-Dependent Effects on
RNA
Stability
508
Regulation of Translation
508
Regulation of Translation Initiation
509
xii
CONTENTS
Translational Regulation in
the Exit
Channel
of the
Ribosome 511
Regulation
of
Translation
Termination
512
Posttranslational Regulation 514
Posttranslational Protein
Modification
514
Regulation
of
Protein
Turnover
514
Feedback Inhibition
of
Enzyme
Activity
515
Why Are There So Many Mechanisms of
Gene
Regulation?
520
Operon Analysis for Sequenced Genomes
521
BOX
12.1
The Helix-Turn-Helix Motif of DNA-Binding
Proteins
473
BOX
12.2
Families of Regulators
488
BOX
123
Special Problems in Genetic Analysis of
Opérons
516
SUMMARY
521
QUESTIONS FOR THOUGHT
522
PROBLEMS
522
SUGGESTED READING
523
CHAPTER
13_____________________
Global Regulation:
Régulons
and
Stimulons
525
Carbon Catabolite Regulation
526
Catabolite Regulation in
£
coli:
Catabolite Activator
Protein (CAP) and cAMP
526
Carbon Catabolite Regulation in
ß. subtilis:
CcpA and
Hpr
535
Regulation of Nitrogen Assimilation
536
Pathways for Nitrogen Assimilation
536
Regulation of Nitrogen Assimilation Pathways in
£
coli
by the Ntr System
537
Regulation of Nitrogen Assimilation in
ß.
subtilis
547
Regulation of Ribosome and tRNA
Synthesis
547
Ribosomal Protein Gene Regulation
548
Regulation of rRNA and tRNA Synthesis
550
The Stringent Response
551
Stress Responses in Bacteria
554
Heat Shock Regulation
555
General Stress Response in Gram-Negative
Bacteria
558
General Stress Response in Gram-Positive
Bacteria
559
Extracytoplasmic (Envelope) Stress Responses
563
Iron Regulation in
E. coli
568
The Fur Regulon
568
TheRyhBsRNA
569
The Aconitase Translational
Repressor
570
Regulation of Virulence Genes in Pathogenic
Bacteria
571
Diphtheria
572
Cholera and Quorum Sensing
572
Whooping Cough
578
From Genes to
Régulons
to Networks
579
BOX
13.1
cAMP-lndependent Carbon Catabolite
Regulation in
E. coli
529
BOX
13.2
A Bacterial Two-Hybrid System Based on
Adenylate Cyclase
531
BOX
13.3
Nitrogen Fixation
537
BOX
13.4
Signal Transduction Systems in
Bacteria
539
BOX
13.5
Sigma Factors
542
BOX
13.6
Regulatory RNAs
560
BOX
13.7
Tools for Studying Global
Regulation
571
SUMMARY
580
QUESTIONS FOR THOUGHT
582
PROBLEMS
582
SUGGESTED READING
582
CHAPTER
14
Bacterial Cell Biology and
Development
585
Membrane Proteins and Protein Export
585
The Translocase System
586
The Signal Sequence
586
The Targeting Factors
588
The Tat Secretion Pathway
590
Disulfide Bonds
590
Use of mal-lac Fusions To Study Protein Transport in
£
coli
591
Genetic Analysis of
Transmembrane
Domains
of Inner Membrane Proteins in Gram-Negative
Bacteria
594
Identification of Genes for Inner Membrane Proteins
by Random phoA Fusions
595
CONTENTS
xiii
Protein
Secretion
595
Protein
Secretion
Systems in Gram-Negative
Bacteria
595
Protein
Secretion in Gram-Positive Bacteria
602
Sortases
603
Bacterial Cell Biology and the Cell Cycle
605
The Bacterial Cell Wall
606
Septum Formation
615
The FtsZ Protein and the
Šeptal
Ring
616
Regulation of FtsZ Ring Formation in
С
crescentus
619
Genetic Analysis of
Sporulation
in
ß.
subtilis
621
Identification of Genes That Regulate
Sporulation
622
Regulation of Initiation of
Sporulation
623
Compartmentalized Regulation of
Sporulation
Genes
627
Analysis of the Role of Sigma Factors in
Sporulation
Regulation
627
Intercompartmental Regulation during
Development
630
Finding
Sporulation
Genes: Mutant Hunts, Suppressor
Analysis, and Functional Genomics
635
BOX
14.1
Secretion Systems and Motility
599
BOX
14.2
Example of a Sortase-Dependent Pathway:
Sporulation
in
5.
coelicolor
605
BOX
14.3
Evolutionary Origin of the Eukaryotic
Cytoskeleton
612
BOX
14.4
Phosphorelay Activation of the
Transcription Factor SpoOA
625
SUMMARY
636
QUESTIONS FOR THOUGHT
637
PROBLEMS
637
SUGGESTED READING
638
Answers to Problems and Questions for
Thought
641
Glossary
655
Figure and Table Credits
685
Index
689
|
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| ctrlnum | (OCoLC)815945016 (DE-599)BVBBV040458951 |
| discipline | Biologie |
| edition | 4. ed. |
| format | Book |
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| id | DE-604.BV040458951 |
| illustrated | Illustrated |
| indexdate | 2024-11-25T17:37:10Z |
| institution | BVB |
| isbn | 1555816274 9781555816278 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025306442 |
| oclc_num | 815945016 |
| open_access_boolean | |
| owner | DE-20 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-11 DE-29T DE-703 DE-91G DE-BY-TUM DE-M49 DE-BY-TUM |
| owner_facet | DE-20 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-11 DE-29T DE-703 DE-91G DE-BY-TUM DE-M49 DE-BY-TUM |
| physical | XX, 707 S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | ASM Press |
| record_format | marc |
| spellingShingle | Molecular genetics of bacteria Larry Snyder ... Gentechnologie (DE-588)4071722-7 gnd Bakteriophagen (DE-588)4125508-2 gnd Bakterien (DE-588)4004296-0 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| subject_GND | (DE-588)4071722-7 (DE-588)4125508-2 (DE-588)4004296-0 (DE-588)4039987-4 |
| title | Molecular genetics of bacteria Larry Snyder ... |
| title_auth | Molecular genetics of bacteria Larry Snyder ... |
| title_exact_search | Molecular genetics of bacteria Larry Snyder ... |
| title_full | Molecular genetics of bacteria Larry Snyder ... |
| title_fullStr | Molecular genetics of bacteria Larry Snyder ... |
| title_full_unstemmed | Molecular genetics of bacteria Larry Snyder ... |
| title_short | Molecular genetics of bacteria |
| title_sort | molecular genetics of bacteria larry snyder |
| title_sub | Larry Snyder ... |
| topic | Gentechnologie (DE-588)4071722-7 gnd Bakteriophagen (DE-588)4125508-2 gnd Bakterien (DE-588)4004296-0 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| topic_facet | Gentechnologie Bakteriophagen Bakterien Molekulargenetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025306442&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT snyderlarry moleculargeneticsofbacterialarrysnyder |